BAB 5 KESIMPULAN DAN SARAN
5.2. Saran
Berdasarkan penelitian yang telah dilakukan, untuk mendapatkan formula yang terbaik perlu dilakukan penelitian lebih lanjut terhadap uji penetrasi masing- masing formula niosom yang mengandung ekstrak kulit batang nangka (Artocarpus heterophyllus L.).
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DAFTAR PUSTAKA
Aditria, Riswandi. Cahyono, Bambang. Swastawati, Fronthea. 2013. Identifikasi komponen penyusun asap cair dari ampas sagu dan kulit batang tanaman sagu (Metroxylon sagu Rottb) serta penentuan senyawa fenolat total dan aktivitas antioksida. Semarang: Universitas Diponegoro. 02 (01): 240-246.
Alfian, Riza. Susanti, Hari. 2012. Determination of total phenolic content of methanolic extracts red rosell (Hibiscus sabdariffa L.) calyxs in variation of growing area by spectrophotometry. Yogyakarta: Fakultas Farmasi, Universitas Ahmad Dahlan. 02 (1): 73-80.
Anonim, 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Departemen Kesehatan RI.
Ansel, H.C. (1989). Pengantar Bentuk Sediaan Farmasi, edisi keempat. Terj. Dari
Introduction to Pharmaceutical Dosage Form, oleh Farida Ibrahim. Jakarta: UI Press.
Anwar, Effionora. Henry. Jufri, Mahdi. 2004. Studi kemampuan niosom yang menggunakan maltodekstrin pati garut (Maranta arundinaceae L.)
sebagai pembawa klorfeniramin maleat. Depok : FMIPA UI.
Arifin, Helmi. Anggraini, Nelvi. Handayani, Dian. Rasyid, Roslinda. 2006. Standarisasi ekstrak etanol daun Eugenia cumini Merr. Jurnal Sains Tek Far. 11 (2). Padang : FMIPA UNAND.
Astirin, Okin Parama. 2000. Permasalahan pengelolaan keanekaragaman hayati indonesia. Surakarta: Jurusan Biologi FMIPA UNS.
Avandi, M, R.. Sadeghi, A. M, M. Mohammadpour, N. Abedin, S. Atyababi, F. Dinarvand, R. Tehrani, R, M. 2009. Preparation and characteritation of insulin nanoparticles using chitosan and arabic gum with ionic gelation method.Nanomedicine: 6. 58-63.
Bansal, Saurabh. Kashyap, Chandan. Aggarwal, Geeta. Harikumar, SL. 2012. A
comparative review on vesicular drug delivery system and stability issues.
International Journal Of Research In Pharmacy And Chemistry. 2231- 2781.
Barenholz, Y. Crommelin, DJA. 1994. Liposomes as Pharmaceutical Dosage Forms. Encyclopedia Of Pharmaceutical Technology. Inc. 9. 1-39.
UIN Syarif Hidayatullah Jakarta
Bayindir, Zerrin Sezgin. Yuksel, Nilufer. 2009. Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery.
Pharmacetical Technology. DOI 10. 1002/jps.21944.
Biju, S.S. Talegaonkar, S. Mishra, P.R. Khar, R.K. 2006. Vesikular system: an overview. Indian Journal Of Pharmaceutical Science. 68(2): 141-153.
Blazzek, Welsh Al. Rhodes, DG. 2001. SEM imaging predicts quality of niosomes from maltodextrin based proniosomes. Pharmaceutical Research. 18(5): 1-6.
Buckton, G. 1995. Interfacial phenomena in drug delivery and targetting. Switzerland. Harwood Academic Publisher. 135-161.
Chandu, V. Pola. Arunachalam, A. Jeganath, S. Yamini, K. Tharangini, K. Chaitanya, G. 2012. Niosomes: a novel drug delivery system.
International journal of novel trends in pharmaceutical sciences. IJNTPS. 2: 25-31.
Chang, T.S. 2009. An updated review of tyrosinase inhibitors. Department of Biological Science and Technology. Taiwan: National University Taiwan.
Connor, Steven. 2003. The Book Of Skin. New York: Cornell University Press, 176.
Day, R. A dan Underwood, A. 2002. Analisis Kimia Kuantitatif Edisi Ke-6.
Erlangga: Jakarta.
Departemen Kesehatan RI. 1989. Materia Medika Indonesia. Jakarta: Departemen Kesehatan RI.
Departemen Kesehatan RI. 2000. Acuan Sediaan Herbal. Direktorat Jendral Pengawasan Obat dan Makanan, Jakarta : 115-117.
Dewi, I.D.A.D.Y. dkk. 2013. Skrining fitokimia ekstrak etanol 95% kulit buah manggis (Garcinia mangostana L.). Bali: Jurusan Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana.
Dhamecha, Dinesh. Rathi, Amit. Saifee, Maria. Lahoti, Swaroop, Dehghan, Mohd Hassa. 2005. Drug vehicle based approaches of penetrastion enhancement.
International Journal of Pharmacy and Pharmaceutical Sciences.Vol 1. 1.
Donsing, P. and Viyoch, J. (2008). Thai breadfruitûs heartwood extract: a new approach to skin whitening.Journal of SWU Sciences. Vol. 24, No. 1.
Dua. Anil, Bhandari. Rana. 2014. Formulation and caharcterization of serratiopeptidase niosomes for its systemic gastrointestinal delivery.
UIN Syarif Hidayatullah Jakarta
Elevitch, C. R., & Manner, H. I. (2006). Artocarpus heterphyllus (Jackfruit). Species Profiles For Pacific Island Agroforestry. www.traditionaltree.org. Diakses pada 25 November 2014 jam 00.30.
Faraji, A. H., dan Wipf, P. (2009). Nanoparticles in celluler drug delivery.
Bioorganic & Medical Chemistry. 17, 2950-2962.
Farnsworth, N.R. (1966). Biological and phytochemical screening of plants.
Journal Of Pharmaceutical Science. 55 (3): 225 – 276.
Fauzy, Aprilla. 2012. Pengaruh Konsentrasi Minyak Ikan Terhadap Penetrasi Kurkumin Dalam Sediaan Mikroemulsi Gel (skripsi). Depok : FMIPA UI.
Folin, Octo, Ciocalteu, Vintila, 1999. On tyrosinase and tryptophane determinations in proteins. Journal Bio Chem. 73: 627-650.
Gandjar, Ibnu Gholib dan Rohman, Abdul. 2007. Kimia Farmasi Analisis. Universitas Gadjah Mada Yogyakarta.
Gaur, P.K. Mishra, S. Purohit, S. Dave. K. 2009. Transdermal drug delivery system: a review. Asian Journal of Pharmaceutical and Clinical Research.
Vol: 2 (01).
Handayani, Puput. 2011. Optimasi Komposisi Cetyl Alcohol Sebagai Emulsifying Agent Dan Gliserin Sebagai Humectant Dalam Krim Sunscreen Ekstrak Kental Apel Merah (Pyrus malus L.): Aplikasi Desain Faktorial. Yogyakarta: Fakultas Farmasi, Universitas Sanata Dharma.
Hanifah, Nisa Dian. 2013. Formulasi Krim Ekstrak Batang Nangka (Artocarpus Heterophyllus Lamk.). Bandung: FMIPA UNISBA.
Hao,Yongmei. Zhao, Fenglin. Yang, Yanhong. Li, Ke’an. 2002. Studies on a high encapsulation of colchicine by a niosome system. International Journal of pharmaceutics. China : College of Chemistry and Molecular Enginering.
Harborne, J.B. (1987). Metode Fitokimia. Bandung: Penerbit ITB.
Hidayat, Erwin. 2006. Pengaruh nilai de maltodekstrin dari pati singkong (manihot utilissima l.) terhadap pelepasan ketoprofen dari sediaan niosom
(skripsi). Depok : FMIPA UI.
Hindritiani, Reti, et al. 2013. Penurunan aktivitas tirosinase dan jumlah melanin oleh fraksi etil asetat buah malaka (Phyllantus emblica) pada mouse melanoma b16 cell-line. 45 (2): 118-24.
UIN Syarif Hidayatullah Jakarta
Indriyani, Susi. 2006. Pengaruh maltodekstrin de 10-15 dan 15-20 terhadap laju pelepasan klorfeniramin maleat dari sediaan niosom (skripsi). Depok : FMIPA UI.
Jahanshashi & Babei. 2008. Protein nanoparticle: a unique system as drug delivery vehicles.Journal Biotechnology. 7(25). 4926-4934.
Jufri, Mahdi. Effionora Anwar. Joshita Djajadisastra. 2004. Pembuatan niosom berbasis maltodekstrin de 5-10 dari pati singkong (Manihot utilissima).
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia. ISSN: 1693-9883, Vol. I, No. 1.
Juwita, Ninin Kartika. Joshita Djajadisastra. Azizahwati. 2011. Uji penghambatan tirosinase dan stabilitas fisik sediaan krim pemutih yang mengandung ekstrak kulit batang nangka (Artocarpus heterophyllus). Majalah Kefarmasian. Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Indonesia.
Kapoor, Anupriya. Gahoi, R. Kumar, D. 2011. In vitro drug release profile of acyclovir from niosomes formed with different sorbitan esters. Asian Journal Of Pharmacy & Life Science. 1 (1).
Lanimarta, Yurika. 2012. Pembuatan dan uji penetrasi nanopartikel kurkumin- dendrimer poliamidoamin (pamam) generasi 4 dalam sediaan gel dengan menggunakan sel difusi franz (skripsi). Depok: FMIPA UI.
Lasic, D.D. & Papahadjopoulos, D. (1998). Medical aplication of liposomes.
Elseiver. 1-2.
Li, Danhui. Zimei Wu. Nataly Martini. Jingyuan Wen. 2012. Advanced carrier systems in cosmetics and cosmeceuticals. New Zealand: School of Pharmacy, Faculty of Medical and Health Sciences, The University Of Auckland. J. Cosmet. Sci. 62, 549 – 563.
Lund, W. 1994. The Pharmaceutical Codex, 12th edition. London: The Pharmaceutical Press.
Madison KC. 2003. Barrier function of the skin: “la raison d’etre” of the
epidermis. J Invest Dermatol. 121(2)231.
Maghraby. Barry. Williams. 2008. Liposomes and skin: from drug delivery to model membranes. European Journal Of Pharmaceutical Sciences. 34, 203-222.
Mahardika, Hastri. 2012. Uji penghambatan tirosinase secara in vitro serta stabilitas fisik dan stabilitas kimia sediaan krim yang mengandung asam azelat (skripsi). Depok: FMIPA UI.
UIN Syarif Hidayatullah Jakarta
Makeshawar, Kshitij B. Wasankar, Suraj R. 2013. Niosome: a novel drug delivery system. Asian Parmapres 3(1), 16-20.
Manosroi, Aranya. 2011. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Natural Products Research and Development Center (NPRDC).50(2): 208–224.
Maureen, Maguire. 2002. The mouse GaIR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization. Journal of Neurochemistry. 71(6).
Mescher, Anthony L. 2011. Histologi Dasar Junqueira: Teks & Atlas. Jakarta: EGC.
Miyazawa, Mitsuo And Naotaka Tamura. (2006). Inhibitory compound of tyrosinase activity from the sprout of Polygonum hydropiper L. (Benitade). J. Biol. Pharm. Bull. 595-597.
Mohanraj, V.J. Chen, Y. (2006). Nanoparticle-a review. Tropical Journal of Pharmaceutical Research. 5 (1), 561-573.
Mujoriya, Rajesh Z. Bodla, Ramesh Babu. 2011. Niosomes–challenge in preparation for pharmaceutical scientist. International Journal Of Applied Pharmaceutics. 3 (3), 11-15.
Perkins, Warren S. 1998. Surfactants a primer. 51-54. Diakses melalui http://www.p2pays.org. Pada tanggal 22 Februari 2015.
Pham, Thi Thuy. Maalej, Chiraz Jaafar. Charcosset Catherine. Fessi, Hatem. 2012. Colloids and surfaces b: biointerfaces liposome and niosome preparation using a membrane contactor for scale-up. Elsevier. 94, 15 - 21.
Pontis, Alves Jonierison. Costa, Luiz Antonio Mendonca Alves. Silva, Silvio Jose Reis. Flach, Adriana. 2014. Color, phenolic and flavonoid content, and antioxidant activity of honey from roraima. Food Science and Technology.
Brazil: Campinas., 34(1) : 69-73. ISSN 0101-2061. Diakses 10 Desember 2014.
Prihatman, K. 2000. Nangka (Artocarpus heterophillus L.), sistem informasi manajemen pembangunan di pedesaan. BAPPENAS. p. 1-15.
Putri, Wisda Seviana. Supriyanti, F. M Titin. Zackiyah. 2012. Penentuan aktivitas dan jenis inhibisi ekstrak metanol kulit batang nangka (Artocarpus heterophyllus L.) sebagai inhibitor tirosinase. FPMIPA UPI. ISSN 2087- 7412, Vol 1, No 1.
UIN Syarif Hidayatullah Jakarta
Rahimpour, Yahya, Hamed Hamishehkar. 2012. Recent advances in novel drug carrier system: niosomes as carrier in dermal drug delivery. Iran: Tabriz University of Medical Sciences.
Rahman, Latifah. Ismail, Isriany. Wahyudin, Elly. 2011. Kapasitas jerap niosom terhadap ketoprofen dan prediksi penggunaan transdermal. Majalah farmasi Indonesia. 22(2). 85-91.
Rahmawati, Anita. 2009. Kandungan fenol total ekstrak buah mengkudu (Morinda citrifolia). Depok: Fakultas Kedokteran Universitas Indonesia.
Ramsden, Christopher A. Riley, Patrick A. 2010. Studies of the competing rates of catechol oxidation and suicide inactivation of tyrosinase. Arkivoc. (x). 248-254.
Ratnayani, Ketut A.A.I.A. dkk. 2012. Kadar total senyawa fenolat pada madu randu dan madu kelengkeng serta uji aktivitas antiradikal bebas dengan metode DPPH (Difenilpikril Hidrazil). Jurnal Kimia. Jurusan Kimia FMIPA Universitas Udayana, Bukit, Jimbaran. 6(2) : 163-168.
Rawat, M. Singh, D. Singh, S.S. Saraf, S. (2006). Nanocarries : Promising vehicle for bioactive drugs. Niol. Pharm, Bull 29 (9), 1790-1798.
Reynolds, J.E.F. eds. 1996. Martindale the Extra Pharmacopoeia, 31th ed. London: The Pharmaceutical Press.
Robinson, T. (1991). Kandungan Organik Tumbuhan Tingkat Tinggi. Bandung: Penerbit ITB. Hal. 152 – 196.
Rohman. 2007. Kimia Farmasi Analisis. Yogyakarta : Pustaka Pelajar.
Rowe, C.R.. Sheskey, J.P. Owen, C.S. 2006, Handbook Of Pharmaceutical Excipients, 5th edition, 731-732. London, Chicago: American Pharmaceutical Association.
Ruckmani, Kandasamy & Sankar, Veintramuthu. 2010. Formulation and optimization of zidovudine niosomes. American Association of Pharmaceutical Scientists. 03(03) : 1119-1127.
Sabarikumar, K. Varatharajan, P. Ilavarasan, P. Shaik, Sheema Meenaz. 2012. Bioavaibility enhancement of aceclofenac niosomes containing surfactant and cholesterol. International Journal of Biological and Pharmaceutical Research. 3(3): 354-359. India.
Saifudin, A., V. Rahayu, dan H.Y. Teruna. 2011. Standardisasi Bahan Obat Alam. Yogyakarta: Graha Ilmu.
UIN Syarif Hidayatullah Jakarta
Sankhyan, Anchal. Pawar, Pravin. 2012. Recent trends in niosome as vesicular drug delivery system. Journal of Applied Pharmaceutical Science. 02 (06). 20-32.
Sari, Zhuisa Martiara. 2012. Pembuatan dan karakterisasi fisikokimia nanopartikel emas (nanogold)-dendrimer poliamidoamin (pamam) generasi 4 (skripsi). Depok: FMIPA UI.
Sharma, Anju. Kumar, Senthil. Mahadevan, N. M. 2012. Nanotechnology: a promising approach for cosmetics. International Journal of Recent Advances in Pharmaceutical Research. 2(2): 54-61.
Sharma, Sandeep Kumar. Chauchan, Meenakshi. Anilkumar, Narayanapillay. 2009. Span-60 niosomal oral suspension of fluconazole: formulation and in vitro evaluation. Research Article. 1(01). 142-156.
Shatalebi. Mostafavi. Moghaddas. 2010. Niosomes as a drug carrier for topical delivery of N-acetyl glucosamine. Research pharmaceutical sciences.
Sherwood, Lauralee. 2007. Fisiologi Manusia. Jakarta : EGC.
Singleton VL & Rossi JA. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 16 (3): 144-58.
Stojanovic, Zoran. Markovic, Smilja. 2010. “Technics New Material”. determination of particle size distributions by laser diffraction. Belgrade. 21, 11 – 20.
Sukriya, Ikha Novita Ma’wa. 2011. Formulasi surfaktan untuk screening awal chemical flooding pada eor (enhanced oil recovery). Fakultas Teknik Program Ekstensi Teknik Kimia. UI Depok.
Supriyanti, Florentina Maria Titin. 2009. Studi inhibisi ekstrak metanol kulit batang Artocarpus sp. dalam mencegah hiperpigmentasi kulit. Bandung: FMIPA UPI.
Sylvia, Anderson Pierce. Lorraine, McCarty Wilson. 2005. Patofisiologi: Konsep Klinis Proses-Proses Penyakit Ed 6. Jakarta EGC.
Tang, Muhamad dan Veinardi Suendo. 2011. Pengaruh penambahan pelarut organik terhadap tegangan permukaan larutan sabun. Prosiding simposium nasional Inovasi pembelajaran dan sains (SNIPS). Bandung, Indonesia.
Tangri et al. 2011. Niosomes: formulation and evaluation. Uttarakhand: Faculty of Pharmacy-Mussoorie Diversion Road.
UIN Syarif Hidayatullah Jakarta
Thassu, D., Pathak, Y. dan Deleers, M. 2007. Nanoparticulate drug-delivery systems: an overview. Informa Healthcare, New York. 1–31.
Tim, Lili. 2004. Pembuatan niosom dengan menggunakan lesitin sebagai pengganti kolesterol. Depok : FMIPA UI.
Touitou, Elka. Barry, Brian W. 2007. Enhancement In Drug Delivery. New York: CRC Press, 220-221, 237, 246.
Tranggono, RIS. Fatma Latifah. 2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT Gramedia Pustaka Utama.
Uchegbu, IF. Vyas, SP. 1989. Non-ionic surfactant based vesicles (niosomes) in drug delivery. International Journal of Pharmaceutics. 172 (1-2). 33-70.
Van, Hal, D,A. Bouwstra, J,A. Van, Rensen, A. Jeremiasse, E. De Vringer, T. Junginger, H,E. 1996. Preparation and characteritation of nonionic surfactant vesicles. J. Coll. Interf. Sci. 178, 263-273.
Verma, D.D. Blume, G. Fahr, A. 2003. Particle size of liposomes dermal delivery of subtanaces inti skin. International Journal of Pharmaceutics. 2581 (1- 2): 141-151.
Vyas SP and Khar RK. 2011. Targeted And Controlled Drug Delivery Novel Carrier Systems. CBS Publisher and Distributors. 249-279.
Zahra, Soraya. 2012. Optimalisasi formula sunscreen cream berbahan aktif nanopropolis dengan menggunakan emollient isopropyl myristate dan emulsifier span 60. Depok: FT UI.
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