Appendix table 3A: Calcineurin inhibitors trough levels at various time points in cohort A and B
Cohort A (N=23) Cohort B (N=18)
At DAA
initiation At DAA
completion At SVR12 At 6-month
follow-up At 1-year follow-up Average tacrolimus
trough 8.7
(7.8-10.4) 8.8
(7.6-10.7) 10.7
(8.4-11.9) 8.8
(7.4, 11.9) 6.6 (6, 8.2) Average
cyclosporin trough 113
(107-234) 205
(131-244) 172
(159-183) 232
(220, 244) 213 (182, 244) Appendix table 3B: Relationship between Calcineurin inhibitors trough levels and eGFR at various time points in cohort A and B
Correlation co- efficient between tacrolimus trough
and eGFR
-0.07
(p=0.764) -0.175
(p=0.502) -0.12
(p=0.639) -0.39
(p=0.207) 0.507 (p=0.077)
*Correlation between cyclosporin level and eGFR values was not tested due to sample size of 3 patients only.
