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Table 1

Surgical Training/Assessment

Reference Study design Technology used Topic studied Summary of purpose Summary of findings

AR Menozzi 20209

No study design

specified Microsoft HoloLens

Vitreoretinal surgery

Investigated the effect of an AR training simulator on motor skills.

Study found it’s possible to improve microsurgical motor skills using the developed AR simulator

Ropelato 20208

No study design specified

Surgical simulator prototype developed using Microsoft HoloLens

Vitreoretinal surgery

Used AR to develop a simulator for training microsurgical skills.

AR surgical simulator can be used to train micromanipulation skills

VR

Spiteri 201413 No study design

specified EyeSi Simulator Cataract

surgery

Developed an evidence based and proficiency-based training curriculum for phacoemulsification surgery for novices.

Evidence based and proficiency-based training curriculum was developed for phacoemulsification surgery for novices which demonstrated construct validity.

Sikder 201523 Prospective, unmasked,

Non-randomized study MicroVisTouch Cataract

surgery Assessed whether OR experience impacted capsulorhexis

performance using the MicroVisTouch simulator. Improved simulator performance correlated with cataract surgery experience in the OR.

Thomsen 201519

Prospective controlled

interventional study EyeSi Simulator

Cataract surgery

Designed an evidence-based pass/fail assessment tool for cataract surgery and investigated whether the simulator content is specific for cataract surgery

Successfully designed an evidence-based pass/fail assessment tool for cataract surgery and found EyeSi assessed general microsurgical skills.

Gonzalez- Gonzalez 201630

Nonrandomized,

prospective study EyeSi Simulator

Cataract surgery

Determined whether a structured training program using the simulator improved dexterity in non-dominant (ND) hands.

There was improvement in the overall average scores comparing baseline vs. final performances in both the dominant hand and the non-dominant hand.

McCannel 201726

Retrospective educational interventional

case series EyeSi Simulator Cataract

surgery

Assessed vitreous loss rates during cataract surgery in order to demonstrate the specificity of simulation-based VR cataract surgery using the EyeSi simulator.

Overall vitreous loss rates were not lower in those who completed EyeSi capsulorhexis training, but non-errant capsulorhexis associated vitreous loss rates were higher.

Roohipoor

201717 Retrospective study EyeSi Simulator Cataract surgery

Examined the relationship between EyeSi scores of first- year ophthalmology residents and OR performance measures in the final year of residency.

There was a significant correlation between EyeSi scores of first-year ophthalmology residents and OR performance measured in the final year of residency.

Thomsen

201722 Cross-sectional study EyeSi Simulator Cataract surgery

Examined the correlation between different objective measures of cataract surgical performance in a VR environment and in the OR using two objective assessment tools with validity.

There was a correlation between the simulator performance score and the mean Objective Structured Assessment of Cataract Surgical Skill ( OSACSS) score across all experience levels.

Thomsen 201715

Multi-center non- randomized masked

clinical trial EyeSi Simulator

Cataract surgery

Determined the effect of VR proficiency-based training on real cataract surgery performance.

Both novices and intermediates had significant improvements in performance after VR training as judged by 3 independent masked raters using the Objective Structured Assessment of Cataract Surgical Skill (OSACSS).

Ng 201818

cross-sectional

multicenter survey EyeSi Simulator

Cataract surgery

Evaluated the impact that virtual reality training had on residents’ perceived barriers to learning phacoemulsification.

EyeSi simulation training was associated with increased confidence in performing the most difficult tasks perceived during phacoemulsification.

Oflaz 201824

No study design

specified EyeSi simulator

Cataract surgery

Assessed whether cataract surgical simulator performance correlated to real-life surgical experience

A correlation was found between participants’ surgical experience and their scores in the capsulorhexis module.

Jacobsen 201916

Prospective multicenter

study EyeSi Simulator

Cataract surgery

Evaluated the correlation between performance on the EyeSi simulator and real-life cataract surgical performance.

A correlation was found between the EyeSi simulator score and real life performance across all experience levels measured using the Objective Structured Assessment of Cataract Surgical Skill (OSACSS).

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Ferris 202020 Audit Study EyeSi Simulator

Cataract surgery

Investigated the impact of cataract training using the EyeSi surgical simulator on posterior capsule rupture rates of first and second year residents over a 7 year period.

Demonstrated an association between the introduction of training with the EyeSi surgical simulator and a reduction in posterior capsule rupture rates during live surgery.

Forslund Jacobsen 202014

Prospective interventional cohort

study EyeSi Simulator Cataract

surgery Developed and investigated an EyeSi simulator-based test for experienced cataract surgeons

Not all of the advanced cataract surgical modules were able to discriminate between different levels of surgical competence.

Vieira 202029 Multicenter cross-

sectional study EyeSi Simulator Dexterity Used the EyeSi simulator to evaluate dexterity among first

year ophthalmology residents Participants completed two series of dexterity tests and findings showed relevant improvement in dexterity.

Modi 201528 No study design

specified EyeSi surgical simulator Surgical performance

Determined whether there is a relationship between learning style and learned surgical performance using a

VR surgical simulator There was no learning style that resulted in better or worse performance on the EyeSi simulator.

Thomsen 201721

Single-center, single- blinded randomized

controlled trial EyeSi surgical simulator

Surgical performance

Explored inter-procedural transfer of surgical skills and assessed whether pretraining in a cataract surgery using the EyeSi simulator would improve vitreoretinal surgery performance on the EyeSi simulator.

Cataract surgery skills obtained through simulator training did not have any measurable effect on resident vitreoretinal performance on the EyeSi simulator.

McGowan 201832

Randomized cross-over

trial EyeSi surgical simulator

Surgical Performance

To determine whether distraction has an effect on surgical performance in expert and novice surgeons using a VR simulator by asking participants questions about a pre- reading task.

The distraction significantly increased the time taken to perform a simulated vitreoretinal surgery task. There was no significant difference found in cognitive task score or surgical task score.

Forslund Jacobsen 202027

Randomized controlled

crossover study EyeSi surgical simulator

Surgical performance

To investigate the difference between manual and robot assisted vitreoretinal surgery using a VR surgical simulator.

Robot assisted vitreoretinal surgery took longer time, but improved precision and limited tissue damage in comparison to manual surgery.

Mellum 202031

No study design

specified EyeSi surgical simulator

Surgical Performance

To investigate the effect of four distracting factors on vitreoretinal surgery using VR simulator. Distractions included auditory stimuli, fasting, sleep interruption, and sleep deprivation

Lower surgical performance was found with all four distracting factors as measured on the virtual simulator

Deuchler 201625

No study design

specified EyeSi Simulator

Vitreoretinal surgery

Investigated the impact of a warm-up session on the EyeSi surgical simulator prior to live surgery.

Warm up on the EyeSi simulator improved the average performance level of all surgeons.

Vergmann

201711 No study design

specified EyeSi Simulator Vitreoretinal

surgery Assessed the validity of the EyeSi simulator for a

vitreoretinal simulation program Validity was found for four of six vitreoretinal modules on the EyeSi simulator

Cissé 201910 Prospective controlled

clinical trial EyeSi Simulator Vitreoretinal surgery

Investigated the construct validity of six vitreoretinal modules on the EyeSi Surgical Simulator which had not

been previously studied. Experienced surgeons achieved significantly higher median scores than novices in four modules.

Jaud 202012

Prospective controlled

interventional study EyeSi Simulator

Vitreoretinal surgery

Designed an evidence-based performance test to assess vitreoretinal surgical skills using the EyeSi simulator and assessed the validity.

The test demonstrated validity as it was able to differentiate between residents and the experienced surgeons.

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Surgical Guidance

AR

Pan 202034

No study design

specified AR prototype

Corneal suture guidance

Developed a deep learning framework for AR based DALK surgery navigation to assist surgeons with their suturing process.

The developed framework can achieve accurate detection and real-time tracking of corneal contours.

Delisi 201433 No study design specified

Karl Storz Telecam NTSC camera system attached to a Karl Storz 11264BBU1 flexible hysteroscope, AR accomplished through Direct Linear Transform (DLT)

method Transorbital

surgery

Developed an image-guided system using endoscopic video augmentation and investigated the impact of this AR based system on navigating an endoscope to a specified target region in a series of anthropomorphic

phantom experiments. AR based image guidance improved target identification accuracy and reduced procedure time.

VR

Maloca

201835 No study design

specified HTC Vive, Xindian District,

New Taipei City, Taiwan OCT imaging Feasibility testing of novel VR environment in which to display and interact with OCT data

Participants reported an enjoyable VR-OCT experience.

This is a usable and satisfying technique to view and interact with volumetric OCT data.

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