Nordeng H, Lupattelli A, Romøren M, Koren G. Pregnancy outcome after gestational exposure to nitrofurantoin. Obstet Gynecol 2013;121.
The authors provided this information as a supplement to their article.
© Copyright 2013 American College of Obstetricians and Gynecologists.
Page 1 of 2
Appendix 2. Specific Malformations According to the Use of Nitrofurantoin and Pivmecillinam During Pregnancy
Total N = 180,120
Nitro n = 1,334
P
Nitro vs.
Unexposed Controls
Pivmecillinam n = 5,800
P
Pivmecillinam vs.
Unexposed Controls
Unexposed Controls n = 130,889
P
Nitrofurantoin vs.
Pivmecillinam
n (%) n (%) n (%) n (%)
Hypospadias 259 (0.144) 4 (0.300) 0.124 14 (0.241) 0.073 184 (0.141) 0.734 Cleft lip with or without
cleft palate
235 (0.130) 0 (0.000) - 12 (0.207) 0.235 177 (0.135) -
Craniosynostosis 12 (0.007) 0 (0.000) - 0 (0.000) - 10 (0.008) -
Anomaly of scull and face
472 (0.262) 1 (0.075) 0.278 10 (0.172) 0.191 353 (0.270) 1.000
Anophthalmia or microphthalmos
12 0 (0.000) - 1 (0.017) 0.352 9 (0.007) -
Hydrocephalus 94 (0.052) 0 (0.000) - 4 (0.069) 0.554 69 (0.053) -
Transposition of great 84 (0.047) 0 (0.000) - 6 (0.103) 0.051 57 (0.044) -
Nordeng H, Lupattelli A, Romøren M, Koren G. Pregnancy outcome after gestational exposure to nitrofurantoin. Obstet Gynecol 2013;121.
The authors provided this information as a supplement to their article.
© Copyright 2013 American College of Obstetricians and Gynecologists.
Page 2 of 2 Total
N = 180,120
Nitro n = 1,334
P
Nitro vs.
Unexposed Controls
Pivmecillinam n = 5,800
P
Pivmecillinam vs.
Unexposed Controls
Unexposed Controls n = 130,889
P
Nitrofurantoin vs.
Pivmecillinam
vessels
Limb reduction defects 81 (0.045) 0 (0.000) - 1 (0.017) 0.053 62 (0.047) -
Gastroschisis 61 (0.034) 1 (0.075) 0.353 6 (0.103) 0.016 42 (0.032) 1.000
Anorectal atresia 55 (0.031) 1 (0.075) 0.320 4 (0.069) 0.095 37 (0.028) 0.587 Hypoplastic left heart 49 (0.027) 1 (0.075) 0.320 1 (0.017) 1.00 37 (0.028) 0.298
Diaphragmatic hernia 45 (0.025) 0 (0.000) - 1 (0.017) 1.00 38 (0.029) -
Oesophageal atresia 38 (0.021) 0 (0.000) - 2 (0.034) 0.335 26 (0.020) -
Renal agenesis 31 (0.017) 0 (0.000) - 2 (0.034) 0.303 24 (0.018) -
