Souvenir & Book of Abstracts

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Souvenir & Book of Abstracts

Under the Patronage of

HE Prof. Abdullah Mohammad Al-Rubaish President, IAU

Editors

Prof. Ebtesam Abdullah Al-Suhaimi, Ph.D.,

Dr. J. Francis Borgio, Ph.D.,

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Souvenir & Book of Abstracts

Of the 4

^th

Annual IRMC Summer Research Program (IRMC-SRP-2022)

(Institute for Research and Medical Consultations - Summer Research Program for Undergraduate Students –2022)

From the 18^thof July 2022 to the 1^st of September 2022 Organizing by

Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University (IAU)

Dammam, Saudi Arabia __________________

Under the Patronage of

HE Prof. Abdullah Mohammad Al-Rubaish President, IAU

Editors

Prof. Ebtesam Abdullah Al-Suhaimi, Ph.D., Dean & Professor of Endocrinology and Physiology,

Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University

Dr. J. Francis Borgio, Ph.D.,

Chairman & Associate Professor of Molecular Genetics, Co-ordinator of IRMC-SRP-2022,

Mr. Thamer Alshammari, M.Sc.

Editorial Assistant,

Ms. Razan Aldahhan, M.Sc.,

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All rights reserved

King Fahd National Library Cataloging-in-Publication Data Institute for Research and Medical Consultations

Summer Research Program 2022. / Institute for Research and Medical Consultations ,- Dammam , 2022

..p ; ..cm

ISBN: 978-603-91311-7-5

1- Research l-Title

378.531 dc 1444/5407

L.D. no. 1444/5407

ISBN: 978-603-91311-7-5

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I am profoundly fascinated by the remarkable progress of the Institute for Research and Medical Consultations (IRMC) in the fields of Advanced Biomedical, Biotechnology, and Nanomedicine and Technology. I am truly pleased to acknowledge the success of the Summer Research Program for Undergraduate Students – 2022 (IRMC-SRP-2022) organised by IRMC from July 18^th, 2022, to September 1^st, 2022, with perfect adequate preparations for complete onsite research training. The research program was designed in a very relevant way to achieve the objectives of the IAU vision to spread knowledge and serve the community, the goals and developmental endeavours of the Kingdom, "Knowledge-based Society and Economy".

I completely believe that the liberating influence and knowledge obtained by the Saudi summer research students will go a long way towards addressing the challenges not only in our country but around the world. I express my total gratitude to the Dean of IRMC, the Co-

Message from the IAU president

HE Prof. Abdullah Mohammad Al-Rubaish

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The Institute for Research and Medical Consultations (IRMC) is responsible for supporting the teaching faculty, postgraduate and undergraduate students through its programs, which are based on the vision and strategy of IAU scientific research. I am pleased to report that IRMC successfully organized the Summer Research Program for Undergraduate Students - 2022 (IRMC-SRP-2022) from July 18^th, 2022, to the 1^st of September 2022 with adequate preparations for online and complete onsite learning, as well as lab skills, in order to convey the scientific knowledge of IRMC-research scientists to young talents from various academic institutions and serve the Saudi Arabian community. This will boost the commitment of our university dedication to transferring knowledge from the lab to the real world in order to achieve one goal of Saudi Vision 2030. I am convinced that the rich knowledge gained by Saudi summer research students will enable the development of a national and worldwide research platform. I thank the Dean of IRMC, the Co-ordinator, IRMC-SRP-2022 Mentors, the students, and the souvenir editorial team for their hard work and wish them luck with their publications. I respect all of their high ambitions and scientifically sound output in meeting the higher standards of Scientific research and Innovation.

Message from the IAU Vice president

Scientific Research and Innovation

HE Prof. Fahad Ahmad Al-Harbi

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Message from the Dean of the IRMC

Prof. Ebtesam Abdullah Al-Suhaimi

I would like to express my gratitude to His Excellency, Dr. Abdullah M. Al Rubaish, President of the Imam Abdul Rahman bin Faisal University, and Prof. Fahad Al- Harbi, Vice President for Scientific Research and Innovation, for their unwavering support. I envision the institute as part of the IAU's pivotal strategy for exploitation of new fields of research that may challenge the current academic role as an admin and supervisor of the summer research program SRP at the Institute for Research and Medical Consultations (IRMC). The IRMC is working for a future that demands a creative and unconventional response that cuts across traditional disciplines and borders. IRMC scientists and researchers, administrators, and technical organizations are addressing contemporary problems driving medical biology in the interdisciplinary fields of biotechnology, regenerative and nanomedicine, material science, computational modelling, biophysics, bioenergy, and energy. IRMC’s top aim is to teach the local community about biotechnology and nanomedicine, as well as their applications. The IRMC facility is a

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Applications were invited from male and female students to select the best and most enthusiastic students IRMC has successfully completed the program by compiling fourteen abstracts for publication in WOS-indexed journals, as is done every year.

Furthermore, all the internal and external students have received comprehensive theoretical and practical training in order to manage the lab’s core competencies and effectively present their research work. I invite you to visit the IRMC website to learn more about the program’s new research output.

I would like to thank the Co-ordinator of IRMC-SRP-2022, Dr. J.

Francis Borgio, and his team members for their continuous efforts towards the successful completion of the IRMC-SRP-2022. I congratulate the mentors of the IRMC-SRP-2022, Prof. Munerah Abdullah Almessiere, Dr. Sayed AbdulAzeez, Dr. Rabindran Jermy, Dr. Suriya Rehman, Dr. Francis J. Borgio, online mentors (Dr. Noor B. Almandil, Dr. Sarah Almofty, Dr. Dana Almohazey, Prof.

Abdulhadi Baykal, Dr. Yassine Slimani and Dr. Fatimah Al-ahmari), panelist, for their outstanding achievement in completing the research projects and presenting their findings on time. I would like to thank the Admin team, Ms. Hanan Aldossary, Mr. Thamer Alshammari, Ms. Razan Aldahhan, Ms. Maryam Alhalafi and Ms Latifa Yousef Aldossary, for their hard work. All of our students deserve heartfelt gratitude for completing their hard work and adhering to the standards. The Souvenir & Book of Abstracts accurately summarizes the unique scientific experimental findings and discussions among the participating students along with Mentor Scientists of IRMC-SRP-2022. The student participants and the IRMC-SRP-2022 organizing team deserve our heartfelt gratitude.

The IRMC strategic plan forwards to extending its support to all academic and social levels as much as possible.

Message from the Dean of the IRMC

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We are proud to co-ordinate successfully the summer research program for the 4^thyear with the support of IAU and the IRMC family!

Thank you all for your invaluable input.

Dr. Francis J. Borgio

Message from the Co-ordinator of the IRMC-SRP-2022

Chairman, Department of Epidemic Diseases Research,

Associate Professor, Department of Genetic Research

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Table of Contents

Page No.

Title

5 Message from the IAU president

Message from the IAU Vice president for Higher 6 Studies and Scientific Research

7 Message from the Dean of the IRMC

Message from the Co-ordinator of the IRMC-SRP-2022 9

14 About IRMC-SRP-2022

15-16 Objectives and Outcomes of IRMC-SRP-2022

17 Achievements of IRMC-SRP-2022

24 Participants of of IRMC-SRP-2022

26 Mentors and Students

43 IRMC-SRP-2022 Gallery

46 Inauguration

Professional Development Lectures 49

Cultivating Curiosity 68

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About IRMC-SRP-2022

Institute for Research and Medical Consultations (IRMC) has successfully organized the fourth summer research program for undergraduate students research program completely. The undergraduate students from various colleges at Imam Abdulrahman Bin Faisal University (IAU) and other universities from the Kingdom of Saudi Arabia and internationally were selected carefully based on criteria of IRMC, and scientific background of the student, they were involved in a rigorous and multidisciplinary research training.

The program was highly selective and research-based program.

Each student was engaged in designated lab under the supervision of a research mentor. Invited seminars and professional development were conducted onsite and online through interactive lectures delivered by IRMC scientists.

Additionally, IRMC has invited professors from different countries to enrich the program by presenting the trends of international research. Each student is expected to publish full research paper with the mentor at IRMC.

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Objectives

To Participate in Cutting Edge, Interdisciplinary Research Group in The Areas of Biomedical, Biotechnology and Nanotechnology

To Expose the Students to the Real Environment of Research

To Complete Graduate Internship if it is a Requirement for Graduation

To Expose the Students to the Science and Technology from International Resources to Offer the Undergraduate Students the Opportunity to be Junior Researchers and Authors

To Develop Research Skills, Analytical and Writing Skills

To Enhance Critical Thinking

To Improve Communication Skills

To Learning More about Academic Research Career

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Outcomes

IRMC successfully transferred scientific knowledge and technology to sixth batch of talented young Saudi students from six different universities (King Khaled University, Taibah University, Umm Al- Qura University, Hafr Al Batin University, King Faisal University, and Imam Abdulrahman Bin Faisal University).

IRMC has effectively participated in a required internship program for undergraduate graduation for certain colleges like College of Science at IAU and other universities.

IRMC has productively developed qualified research skilled undergraduate students.

All the participants of IRMC-SRP-2022 are ready to submit their scientific abstracts to high impact journals.

Summer research students are given a great chance to exhibit and present their finding in front of eminent audience.

Full text of the summer student’s works are expected to be published in high impact journals.

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Full Paper 1

^st

Author

Abstracts

Achievements of IRMC-SRP

“Optimism is the faith that leads to achievement. Nothing can be done without hope and confidence.”

Helen Keller

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Full Paper 1

^st

Author

Scientific Achievements of the IRMC

Total Publications : 1685

Patents :

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Full Paper 1

^st

Author

Full Paper Co-Author

Publications

Abstracts 1

^st

Author

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Booklets

2020

2021

Link

For Full Text

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Published Papers

2020 2020

Link For Full Text

Link

For Full Text

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Published Abstracts Achievements of IRMC-SRP

2020 2021

Link For Full Text Link

For Full Text

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A team of IRMC-SRP-2022 students have received “First Place

during the E-Poster Presentation and Cash Award of 6000 SAR”

for the project entitled “Characterization of Fetal Nucleated Red Blood Cells in Early Pregnancy Using Microscopic and Molecular Techniques” At “IAU-College of Medicine Research & Innovation day held at the College of Medicine at Imam Abdulrahman Bin Faisal University, on Wednesday

Achievements of IRMC-SRP-2022

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Affiliations of Participants of IRMC-SRP-2022

4

University of Hafr Al Batin

6 3

5 1 2

King Faisal University

Taibah University Umm Al-Qura

University King Khalid

University

IAU

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Mentors and Students

“Tell me and I forget, teach me and I may remember, involve me and I learn.”

Benjamin Franklin

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IRMC-SRP-2022 Students

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Students Mentored by Prof. Munerah Abdullah Almessiere in the Biophysics Laboratory

Biophysics Research Department

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Prof. Munerah Abdullah Almessiere

Professor Department of Nano-Medicine Research

(Mentor)

Dr. Yassine Slimani Associate Professor

Department of Biophysics Research

(Online-Mentor)

Ms. Zainab Hussain Albazroun

Ms. Fatimah

Mahdi Al Nass Ms. Maryam Jawad Alabdullah

Ms. Najwa Ali Barnawi Ms. Halima Mohammed

Alahmed

Biophysics Research Department

Prof. Abdulhadi Baykal Department of Nano-Medicine

Research (Online Mentor)

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Ms. Nedaa Abdulatif Tashkandi, M.Sc.

Department of Nano-Medicine

Mentorship Assistant of the Biophysics

Research Department

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Ms. Amelia Zamora Rionda

Laboratory Technician in the Nano-Medicine Research Department

Mentorship Assistant of the Biophysics Research Department

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Students Mentored by Dr. Rabindran Jermy in the Nano-Medicine Laboratory

Nano-Medicine Research Department

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Dr. Rabindran Jermy Associate Professor

Department of

Nano-Medicine Research (Mentor)

Dr. Dana Abdulrahman Almohazey Assistant Professor

Department of Stem Cell Research

(Online-Mentor)

Ms. Latifah Abdulwahab Aljabari

Ms. Laila Matuq Albuawadh Ms. Fatimah Essa Alsaihati

Mr. Ahmed Abdullah Bukhamsin Mr. Mouad Ahmed

Tuhami

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Ms. Janaica Yu Logan

Mentorship Assistant of the Nano-Medicine Research Department

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Students Mentored by Dr. Suriya Rehman in the Molecular Microbiology Laboratory

Epidemic Diseases Research Department

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Dr. Suriya Rehman Assistant Professor Department of Epidemic

Diseases Research (Mentor)

Dr. Fatima Al-ahmari Assistant Professor

Department of Nano-Medicine Research

(Online-Mentor)

Ms. Laila Muflih Aldossary Ms. Maryam Saleh Alhnout

Ms. Dana

Saleh Alamoud Ms. Hadeel

Khalid Alotaibi

Epidemic Diseases Research Department

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Ms. Zainab Hassan Alsalem, M.Sc.

Department of Epidemic Diseases Research

Mrs. Eman Mohammed

Alsulami, M.Sc.

Department of Epidemic Diseases Research

Mentorship Assistants of the Epidemic Diseases

Research Department

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Students Mentored by Dr. Sayed AbdulAzeez in the Genetics Laboratory

Genetic Research Department

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Genetic Research Department

Dr. Sayed AbdulAzeez Associate Professor

Department of Genetic Research (Mentor)

Dr. Sarah Ameen Almofty Assistant Professor

Department of StemCell Research

(Online-Mentor)

Mr. Bader Salem Alsolo Mr. Ahmed Ali Al Yateem Mr. Adel Abdalla Zeidan

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Students Mentored by Dr. J. Francis Borgio in the Genetics Laboratory

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Dr. Francis J. Borgio

Associate Professor

Department of Genetic Research (Mentor)

Dr. Noor B. Almandil

Associate Professor Department of Clinical

Pharmacy Research (Online-Mentor)

Ms. Sadeem Saleh

Alrubaian Ms. Maraam Mohammed

Al Qout Ms. Ayedah Yhya

Kaabi Ms. Rahaf Mohammed

Alhujaily

Mentors and Students

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Dr. Norah Fahad Alhur Department of Genetic Research

Mentorship Assistant of the Genetic

Research Department

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Mr. Horace Tumulak Pacifico

Laboratory Technician in the

Mr. Ranilo M. Tumbaga

Laboratory Technician in

the Genetic Research Department

Mrs. Jee E. Aquino

Laboratory Technician in the Clinical Pharmacy Research

Department

Mentorship Assistants of the Genetic Research Department

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IRMC Gallery

" The opposite of a correct statement is a false statement. But the opposite of a profound truth may well be another

profound truth.”

Niels Bohr

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Venue

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Laboratories

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“For last year’s words belong to last year’s language And next year’s words await another voice.

And to make an end is to make a beginning.”

T.S. Eliot

Inauguration

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Inauguration

Brief Description - IRMC-SRP-2022

The Training and Development Committee at IRMC under the supervision of Prof. Ebtesam Abdullah Al-Suhaimi, designed the program of IRMC-SRP-2022 by the Chairman of the Committee and co-ordinator of the program, Dr. J Francis Borgio. The event was organized at building number A70, Institute for Research and Medical Consultations (IRMC), and building number A71, Animal House – IRMC at C1 West Campus, Imam Abdulrahman Bin Faisal University (IAU), Dammam, Kingdom of Saudi Arabia. The program was inaugurated by Prof. Ebtesam Abdullah Al-Suhaimi, Ph.D. Dean, Institute for Research and Medical Consultations on 18^th July 2022 at 10.00 AM. Prof. Ebtesam Abdullah Al-Suhaimi welcomed all the mentors and students and elaborated the importance of the IRMC-SRP-2022. Dr. J. Francis Borgio, Co- ordinator of the Summer Research Program – 2022 was briefed about IRMC summer research program and its schedule. The mentors from IRMC made their valuable presence on the day of

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1 st Day Tour

Mr. Melchor “choy” Jimenez Takes the student on a tour to

the IRMC departments and laboratories

Dr. HusseinAbdullah AlHawaj &

Dr. Taleb Taher Alkhamis

Taking the student on a tour to the IRMC’s Animal House

Dr. J. Francis Borgio

Welcomes the students prior to the tour

Inauguration

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Professional Development Lectures

"Education is the most powerful weapon which you can use to change the world.”

Nelson Mandela

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List of Professional Development Lectures, Workshops, Competitions

Day Time

Topic Invited Speaker

18 July 2022 Tuesday 1:00-2:30

Ethical Conduct in Research Prof. Ebtesam

Abdullah Al- Suhaimi

19 July 2022 Tuesday 8:30-10:30

Professional development Lecture1: "Awareness Lecture on Laboratory

Safety"

Prof. Khaled Fikry Salama

20 July 2022 Wednesday 1:00-2:30

Professional Development Lecture 2:

Topics on Research Article Writing -

"Literature Survey and Introduction"

Dr. Dana Abdulrahman

Almohazey

21 July 2022 Thursday 1:00-2:30

Professional Development Lecture3: Topics on Research Article Writing -

"Methodology”

Dr. Rabindran Jermy

27 July 2022 Sunday 1:00-2:30

Professional development Lecture4:

"Laboratory Animals Ethics, Uses and Animals Models"

Dr. Hussein Abdullah AlHawaj

28 July 2022 Wednesday 9:30-2:30

Workshop of Animal Handling Skills Dr. Hussein

Abdullah AlHawaj &

Dr. Taleb Taher Alkhamis

1 Aug 2022 Monday 1:00-2:30

Professional Development Lecture5: Topics on Research Article Writing -

"Results and Discussion"

Dr. Noor B.

Almandil

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Day Time

Topic Invited Speaker

3 Aug 2022 Wednesday 1:00-2:30

Professional Development Lecture 6: Topics on Research Article Writing –

"Abstract, Graphical Abstract, Submitting Articles to Journals"

Dr. Sarah Ameen Almofty

7 Aug 2022 Sunday 1:00-2:30

Professional Development Lecture 7: "Academic Research Support Tools”

Dr. Shakil Ahmad

8 Aug 2022 Monday 1:00-2:30

Professional Development Lecture 8: "Introduction to

Knowledge-Based Economy”

Dr. Zagit Z.

Gaymalov

11 Aug 2022 Thursday 9:00-12:00

"3 Minutes Project competition"

IRMC-SRP-2022 Students

15 Aug 2022 Monday 9:30-2:30

Workshop on SEM/TEM Microscopes Dr. Sultan

Akhtar

22 Aug 2022 Monday 1:00-2:30

The Contribution of Dispersed Systems in Bio- Nanotechnology Advances Prof.

Abdelhamid ELAISSARI

25 Aug 2022 Thursday 1:00-2:30

Professional Development Lecture 9: Oral Presentation Skills Dr. Amani

Alhibshi

List of Professional Development

Lectures, Workshops, Competitions

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July 18 th , 2022

Prof. Ebtesam Abdullah Al-Suhaimi Delivers an online Lecture on Ethical

Conduct in Research

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July 19 th , 2022

Prof. Khaled Fikry Salama

Delivers a Lecture about the Awareness on Laboratory Safety

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Dr. Dana Abdulrahman Almohazey Delivers A Lecture on Research Article Writing:

"Literature Survey and Introduction"

July 20 th , 2022

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Dr. Rabindran Jermy

Delivers A Lecture on Research Article Writing:

"Methodology"

July 21 st , 2022

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Dr. Husain Abdullah Alhawaj

Delivers Lecture on Laboratory Animals Ethics, Uses and Animals Models

July 27 th , 2022

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July 27 th , 2022

Workshop

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July 27 th , 2022

Workshop

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July 27 th , 2022

Workshop

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Dr. Noor B. Almandil

“Results and Discussion"

Aug 1 st , 2022

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Aug 3 rd , 2022

Dr. Sarah Ameen Almofty

"Abstract, Graphical Abstract, Submitting Articles To Journals."

Professional Development Lectures

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Dr. Shakil Ahmad

Delivers an Online Lecture on the Academic Research Support Tools

Aug 7 th , 2022

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Dr. Zagit Z. Gaymalov

Delivers an Online Introduction to Knowledge- Based Economy

Aug 8 th , 2022

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Dr. Sultan Akhtar

Delivers an Introductory Lecture prior to the SEM/TEM Microscope Workshop

Aug 15 th , 2022

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SEM/TEM Microscopes Workshop delivered by Dr.

Sultan Akhtar

Aug 15 th , 2022

Workshop

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Prof. Abdelhamid ELAISSARI

Delivers an Online Lecture on the Contribution of Dispersed Systems in Bio-Nanotechnology Advances

Aug 22 nd , 2022

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Dr. Amani Alhibshi

Delivers an Online Lecture on the Oral Presentation Skills

Aug 22 nd , 2022

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“ If we knew what it was we were doing, it would not be called research, would it?”

Albert Einstein

Cultivating Curiosity

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IRMC-SRP-2022-01 and IRMC-SRP- 2022-02 Students are Performing Different Types of Experiments in their

Assigned Laboratories

Biophysics Laboratories

Ms. Fatimah Mahdi Al Nass (IRMC-SRP-2022-01)

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IRMC-SRP-2022-03 Students are Performing Different Types of Experiments in their Assigned

Laboratories

Ms. Kawthar Mohammed Mogheas (IRMC-SRP-2022-03)

Biophysics Laboratories

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Ms. Latifah Abdulwahab Aljabari (IRMC-SRP-2022-04) Ms. Fatimah Essa Alsaihati

(IRMC-SRP-2022-04)

Laboratories

Nano-Medicine

Laboratories

(72)

Mr. Mouad Ahmed Tuhami (IRMC-SRP-2022-05)

Mr. Abdullah Amer Aljami and Mr. Ali Ibrahim Alkhalaf

(IRMC-SRP-2022-06)

Nano-Medicine

Laboratories

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IRMC-SRP-2022-07, IRMC-SRP-2022-08, and IRMC-SRP-2022-09 Students are

Performing Different Types of Experiments in their Assigned

Laboratories

Molecular Microbiology Laboratory

Ms. Maryam Saleh Alhnout (IRMC-SRP-2022-07)

Ms. Hadeel Khalid Alotaibi (IRMC-SRP-2022-08)

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Genetics Laboratories

Mr. Ahmed Ali Al Yateem and Mr. Bader Salem Alsolo

(IRMC-SRP-2022-11) Mr. Fahad Homoud Aljabbari

(IRMC-SRP-2022-10)

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Laboratories

Ms. Ghadah Ali AlQarni (IRMC-SRP-2022-12) Ms. Manar Ahmed AbuFour

(IRMC-SRP-2022-12)

Genetics Laboratories

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Laboratories

Ms. Sadeem Saleh Alrubaian (IRMC-SRP-2022-13)

Ms. Maraam Mohammed Al Qout (IRMC-SRP-2022-13)

Genetics Laboratories

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Laboratories

Ms. Ayedah Yhya Kaabi (IRMC-SRP-2022-14)

Genetics Laboratories

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Conceptual Competition August 11 th , 2022

“ The day science begins to study non-physical phenomena; it will make more progress in one decade than in all the previous

centuries of its existence.”

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Student Research Conceptual Presentation was held on the 4^th Week of the program, dated Aug 11^th, 2022.

Aim: Three Minutes Project Conceptual Competition is to evaluate the team of students on their competency on understanding the concept of the given research problem.

Panel: The presentations were evaluated by 3- members Panel:

Prof. Ayhan Bozkurt

Dr. Mohammad Azam Ansari Dr. Rabindran Jermy

The team of students were evaluated based on “Research Problem Clearly Stated (30 marks)”, “Clear and Concise Materials and Methods (35 marks)” and “Results/ Expected Easily and Clearly Interpreted (35 marks)” with cumulative total of 100 marks (30+35+35=100).

Conceptual Competition

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Presentations of Students Mentored by Prof. Munerah Abdullah Almessiere

in the Nano-Medicine Research Department

Conceptual Competition

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IRMC-SRP-2022-01

Zainab Hussain Albazroun, Fatimah Mahdi Al Nass, and Maryam Jawad Alabdullah

Ms. Fatimah Mahdi Al Nass

Investigation of Si/Co

_{0 . 6}

M

_{0 . 4}

C e

_{0 . 0 8}

F e

_{2 - x}

O

₄

Magnetic Nanoparticles for Developing Drug

Delivery and Antibacterial Activity

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Najwa Ali Barnawi and Halima Mohammed Alahmed

IRMC-SRP-2022-02

Ms. Najwa Ali Barnawi

Ms. Halima Mohammed Alahmed

Improved Physical Characteristics of 𝑁𝑖𝐹𝑒 2 𝑂 4 Nanoparticles by Adding Selenium for Hydrogen

Evolution Reaction

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Kawthar Mohammed Mogheas and Wasan Saleh Alrubaian

IRMC-SRP-2022-03

Ms. Kawthar Mohammed Mogheas

Study the physical properties of Ga doped Co—Ni Ferrite microspheres

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Presentations of Students Mentored by Dr. Rabindran Jermy in the

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Fatimah Essa Alsaihati, Latifah Abdulwahab Aljabari, and Laila Matuq Albuawadh

IRMC-SRP-2022-04

Ms. Latifah Abdulwahab Aljabari Ms. Fatimah Essa Alsaihati

Developing Zeolite-Mediated

nanocomposite for pulmonary drug delivery to treat Cancer and COVID-19

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Mouad Ahmed Tuhami and Ahmed Abdullah Bukhamsin

IRMC-SRP-2022-05

Mr. Mouad Ahmed Tuhami

Fabrication of Magnetic/SBA-15 Hexagonal Silica and Clay nanotube with Cisplatin nano-composite for potential cancer therapy

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Abdullah Amer Aljami and Ali Ibrahim Alkhalaf

IRMC-SRP-2022-06

Mr. Abdullah Amer Aljami

Developing an Oral Au/Mesoporous Silica/

Polymer Drug Delivery System for Potential Treatment of Diabetes

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Presentations of Students Mentored by Dr. Suriya Rehman in the Epidemic Diseases Research

Department

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Laila Muflih Aldossary and Maryam Saleh Alhnout

Intervention of Nanotechnology for the Treatment of some Important Bacteria Found in Wastewater

IRMC-SRP-2022-07

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Dana Saleh Alamoud and Hadeel Khalid Alotaibi

IRMC-SRP-2022-08

Ms. Dana Saleh Alamoud

Nanomedicine approach in Preventing Biofilm Formation of Staphylococcus aureus

and Pseudomonas

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Reham Hussain Alzahrani and Laila Osama Alibrahim

IRMC-SRP-2022-09

Ms. Reham Hussain Alzahrani

Study of Biofilm production

of Klebsiella pneumoniae (ATCC 700603) and Enterococcus faecalis (ATCC 29212) and their

disruption by therapeutic approach

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Presentations of Students Mentored by Dr. Sayed AbdulAzeez in the

Genetic Research Department

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Fahad Homoud Aljabbari, Hezam Sultan Alqahtani, and Adel Abdalla Zeidan

IRMC-SRP-2022-10

Mr. Hezam Sultan Alqahtani Mr. Fahad Homoud Aljabbari

Identification of Interrupting HBB Variants to Validate the Specificity of a

Novel SCD-Specific ARMS-PCR Assay

Conceptual Competition

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Bader Salem Alsolo and Ahmed Ali Al Yateem

IRMC-SRP-2022-11

Mr. Bader Salem Alsolo

Direct Cell Multiplex PCR for Detecting Gender and Gene Variation in Early Pregnancy

(95)

Presentations of Students Mentored by Dr. J. Francis Borgio in the Genetic Research Department

Conceptual Competition

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Ghadah Ali AlQarni, Manar Ahmed Abufour, and Shahad Mufeed Alali

IRMC-SRP-2022-12

Ms. Ghadah Ali AlQarni Ms. Manar Ahmed AbuFour

Morphological Features of Fetal Nucleated Red Blood Cells in Early Pregnancy Using

Microscopic and Molecular Techniques

Conceptual Competition

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Maraam Mohammed Al Qout and Sadeem Saleh Alrubaian

IRMC-SRP-2022-13

Ms. Maraam Mohammed Al Qout

Variants in OR12D2 Gene in Children with Autism Lower the Risk of Developing ADHD

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Rahaf Mohammed Alhujaily and Ayedah Yhya Kaabi

IRMC-SRP-2022-14

Ms. Rahaf Mohammed Alhujaily

Bacterial genome mining for effective biosynthetic gene cluster against Candida auris

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4 th Annual Poster Day

“No, our science is no illusion. But an illusion it would be to suppose that what science cannot give us we can get

elsewhere.”

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Prof. Ebtesam Abdullah Al-Suhaimi, Dean of IRMC, Welcomes the

Excellences, Guests, Mentors & Participants

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Dr. J. Francis Borgio, Co-Ordinator of the IRMC-SRP-2022, Delivers the

Program Report

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The Audience Are Paying Attention to the Great Poster Presentations by

the IRMC-SRP-2022 Students

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Abstract, Graphical Abstracts, and Posters of IRMC-SRP-2022

1Summer Research Program (SRP-2022), Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

2College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University Dammam, Saudi Arabia

3College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

4College of Dentistry, Imam Abdulrahman Bin Faisal University Dammam, Saudi Arabia

5Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Background: Recently, various novel approaches to combating drug resistance were made possible by the modern technological revolution, including advancements in nanotechnology.

Previous studies have shown that dopped cobalt nano spinel ferrites exhibit an anticancer and antimicrobial effect.

Objective: To investigate antibacterial and anticancer effect of Ce dopped cobalt ferrite that substituted with transitional elements. And its capability to be as drug carrier.

Method and Material: Transition metals of Cu, Zn, Mg, Mn, and Ni were substituted into Ce+3 dopped Co ferrite nanoparticles via a sol–gel technique using citric acid as an ignition agent. Then, synthesized magnetic nanoparticles were encapsulated with silica result in mesopores structured core shell formation. Drug loading was performed using cisplatin and the PEGylation step was performed under argon conditions using the lyophilization

technique. Surface morphology and drug loading was characterized using different techniques such as XRD and SEM were studied. The antibacterial activity was tested on klebsiella pneumoniae.

Results and discussion: XRD analysis of Si/CoCeFeO and Si/CoMnCeFeO samples indicate presence the index peaks of spinel ferrite with amorphous phase at 2 Ɵ= 22°.CoCeFeO Showed complete inhibition growth of Klebsiella pneumoniaecompared to control at higher concentration. CoCeMnFeO Showed 50% inhibition of Klebsiella pneumoniaegrowth compared to control at higher concentration.

Conclusion: In this study we successfully synthesized Si/ CoCeFeO and Si/CoCeMnFeO. The Fatimah Al Nass^1,2, Maryam Alabdullah^1,3, Zainab Albazroun^1,4, and Munerah Almessiere^4,5

Investigation of Si/Co_{0 . 6}M_{0 . 4}C e_{0 . 0 8}F e_{2 - x}O₄ Magnetic Nanoparticles for Developing Drug Delivery and Antibacterial Activity

IRMC-SRP-2022-01

Abstract

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Fatimah Al Nass, Maryam Alabdullah, Zainab Albazroun, and Munerah Almessiere Investigation of Si/Co_{0 . 6}M_{0 . 4}C e_{0 . 0 8}F e_{2 - x}O₄ Magnetic Nanoparticles for Developing

Drug Delivery and Antibacterial Activity

IRMC-SRP-2022-01

Graphical Abstract

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Investigation of Si/Co_{0 . 6}M_{0 . 4}C e_{0 . 0 8}F e_{2 - x}O₄ Magnetic Nanoparticles for Developing Drug Delivery and Antibacterial Activity

IRMC-SRP-2022-01

Poster

Fatimah Al Nass, Maryam Alabdullah, Zainab Albazroun, and Munerah Almessiere

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4 th Annual Poster Day

3Department of Physics, Faculty of Applied Science, Umm AL-Qura University, Al Taif Road, Makkah, 24382, Saudi Arabia

4Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Background: Spinal ferrite magnetic nanoparticles (SFMNPs) attracted a lot of attention due to their magnetic and electrochemical properties. Numerous investigations have shown that the careful selection of doping agents could give a considerable improvement in spinal ferrite compositions. Hence of that, Selenium (Se) was selected which is known as a semiconductor element and has the potential to replace O atoms in the crystalline lattice

structures, thus achieving unique electronic characteristics useful for practical device application. Hydrogen and oxygen evolution reactions (HER

and OER) constitute the bases for electrochemical methods-based water splitting. It became crucial to getting some efficient and cost-effective HER electro-catalysts that can be

affordable and easily available.

Objectives: This study intends to produce a new type of selenium-doped nickel ferrite nanoparticles (Se-NFNPs) composition with different amounts of Se 0.0 − 4.0 using SG- AC-PLAL. Then, the prepared (Se-NFNPs) were utilized via various techniques (XRD, SEM, EDX, TEM, HR-TEM, XPS, VSM, and HER) to determine the improvement of Se doping. The main focus will be on HER required for renewable energy generations.

Methods and Materials: Citric acid, nickel nitrate hexahydrate, and

ferric nitrate nonahydrate were dissolved in (DIW) and brought to heat at 80^oC with a constant stirring. Subsequently, the pH of the solution was adjusted by ammonium hydroxide. After that, the solution was heated at 180 °C for about 35 minutes. Then,

Halima Alahmed^1,2, Najwa Barnawi^1,3, Munerah Almessiere^4*

Improved Physical Characteristics of 𝑁𝑖𝐹𝑒₂𝑂₄Nanoparticles by Adding Selenium for Hydrogen Evolution Reaction.

IRMC-SRP-2022-02

Abstract

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IRMC-SRP-2022-02

Abstract

The obtained gel and the selenium oxide solution were dissolved in DIW and then into ultrasonication. Eventually, the solution was exposed to pulsed laser ablation Nd-

YAG (operates at 532 nm with a pulse duration of 9 ns). For each sample preparation, the laser intensity was controlled via the constant exposure (through a

lens) time (40 min) with continual stirring. The produced colloidal suspension of Se- NFNPs will be oven-dried at 120 °C for about 2 hr.

Results and Discussion: XRD found that the cell parameters were increased by increasing the percentage of Se in contrast with pristine NFO SFNPs. The estimated crystallite size was found to be in the range of 13 to 17 nm by employing Debye Scherrer’s equation on (311) peak. SEM demonstrate the morphology of NFO+x%Sesample with (x=0.0)SFNPs it revealed a significant change due to the preparation method and demonstrated a bulky grain consisting of agglomeration of small particles, while the NFO+x%Se (x=1.0, 2.0, 3.0, and 4.0 %) SFNPsexhibited a distortion in the morphology than x=0.0% and form some sheets on top of the bulky grains. It is noticeable that these sheets were increased with increasing the amount of Se.

EDX analysis revealed the presence of compositional elements including Ni, Fe, Se, and O with no impurity, indicating the efficiency of the green PLAL method. TEM images introduced the morphology of NFO+2%Se SFNPs, it showed high aggregation of small particles size (less than 20 nm). HR-TEM images and electron diffraction patterns verified the formation of pure NFO SFNPs. XPS analysis illustrated the elemental composition with corresponding energy states. The presence of dopant element (Se) was detected by the core level spectrum of Se 3d at the binding energy of 56.4 eV. Further deconvolution of the Se 3d peak introduces two characteristic peaks at 55.4 eV and 56.8 eV that could be attributed to the spin-orbit coupling of 3d_5/2and 3d_3/2respectively.

VSM noticed that undoped NiFe₂O₄has a 15.9 emu/g magnetization at 70 kOe of external DC field while the samples with x=0.0, 1.0, 3.0, and 4.0 Se ion-doped ratios have very close magnetization magnitudes at the same magnitude of a magnetic field. On the other hand, the sample that is doped with 2.0 % of Se content has a significantly larger value of

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4 th Annual Poster Day

IRMC-SRP-2022-02

Abstract

Conclusion: This study has shown a new approach to synthesizing𝑁𝐹𝑂 + 𝑥% 𝑆𝑒 (𝑥 = 0.0

− 4.0)SFNPs using facile pulsed laser ablation in liquid (PLAL). The pure Ni spinel ferrite phase was confirmed via XRD and HR-TEM. The existence of the Se in the spinel structure was verified by EDX and XPS. The magnetic investigations measured

via VSM and proved that all fabricated𝑁𝐹𝑂 + 𝑥% 𝑆𝑒 (𝑥 = 0.0 − 4.0)SFNPs exhibit a superparamagnetic phase under 300 K. The doping process increased the magnetization data remarkably (around 20 % enhancement) for the 2.0 % addition

of Se ion. We believe that the improved HER performance is due to the better electrical conductivity, which makes it easier for the electrons to pass from the electrode to the catalyst surface. Also, the addition of Se introduced nanosheets (as seen in SEM

images) providing more surface areas and active sites to perform catalytic water splitting efficiently.

Key-words: Spinel ferrite nanoparticles, magnetic nanoparticles, Nanocomposite, HER.

Key Messages: Doping selenium in𝑁𝑖𝐹𝑒₂𝑂₄nanoparticles play a significant role in enhancing the characterization of SFNPs which owing to utilized for HER that is required for renewable energy generations.

*Corresponding Author: Prof. Munerah Almessiere, Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal

University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.

Email: [email protected]

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4 th Annual Poster Day

IRMC-SRP-2022-02

Graphical Abstract

Halima Alahmed, Najwa Barnawi, Munerah Almessiere

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IRMC-SRP-2022-02

Poster

Halima Alahmed, Najwa Barnawi, Munerah Almessiere

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3Department of Nano Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Background: The Co0.5Ni0.5GaxFe1.8-xO4 (x ≤ 1.0) microsphere spinel ferrites (MSSFs) will be synthesized hydrothermally. The phase, magnetic and morphological characteristics of MSSFs will be studied using different physico-chemical techniques. Spinel ferrite phase purity and elemental presence in microsphere will be confirmed with XRD and SEM-EDX analyses. Ans also their cubic morphology will be confirmed by SEM and TEM analyses.

Objectives: The effects of Ga3+ on structure, optical-magnetic features and textural

characteristics of Ni-Co MSSFs will be investigated in this study. The distinct magnetic and optical features of the products may result in various application such as absorb microwave radiation.

Methods: The hydrothermal method was applied by preparing Co0.5Ni0.5GaxFe1.8-xO4 (x ≤ 1.0) MSSFs, and the required amounts of Co(NO) 2.6H2O, Fe(NO) 2.9H2O, Ni(NO3) 2.6H2O, and Ga(NO3) ) 2.xH2O was dissolved in 20 ml DI H2O at room temperature (RT), then 100 mg of CSs, 1 g of ascorbic acid, AA (C6H8O6), 1.2 g of urea (CH4N2O) were added to 30 ml of DI water mixed until we obtain a transparent solution, and finally sonication for 30 minutes.

The last product was poured into a stainless-steel autoclave using a Teflon tube, and heated for 12 h at 180 °C. The final product was then thawed with hot DI water, filtered, and dried in the oven.

Kawthar Mogheas^1,2, Wasan Alrubaian^1,2, Dr. Munirah Almessiere³ Study the physical properties of Ga doped Co—Ni Ferrite microspheres

IRMC-SRP-2022-03

Abstract

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Morphology: Figure 2 shows a morphological investigation of the Co0.5Ni0.5GaxFe2.0- xO4 (x = 0.0, 0.2, 0.6, and 1.0) SFMs. The images clearly show aggregated particles of microspheres with different diameters. The microspheres had a rough surface with a diameter of approximately 1 µm. The EDX spectra presented the constituent elements in the microspheres (x = 0.2 and 0.6) as Ni, Co, Fe, Ga, C, and O as shown in Figure 3. In addition, the TEM images of the Co0.5Ni0.5GaxFe2.0-xO4 (x = 0.2 and 0.6) microspheres confirmed the presence of spherical particles as shown in Figure 4.

IRMC-SRP-2022-03

Abstract

Figure 4. TEM and HR-TEM micrographs of Co_0.5Ni_0.5Ga_xFe_2.0-xO₄

(x = 0.2 and 0.6) SFMs

Figure 3. EDX spectra of Co_0.5Ni_0.5Ga_xFe_2.0-xO₄ (x = 0.2 and 0.6) SFMs

Figure 2. SEM images of Co_0.5Ni_0.5Ga_xFe_2.0-xO₄ (x = 0.0, 0.2, 0.6, and 1.0) SEM

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IRMC-SRP-2022-03

Abstract

Conclusions: The correlation between the level of Ga3+ substitution in Co0.5Ni0.5GaxFe2.0-xO4 (x ≤ 1.0) SFMs and their crystal structures, optical

characteristics, and magnetic properties was described. The peculiarities of the phase content and structural using XRD. The microsphere shape is clearly apparent in the SEM and TEM images. Magnetization measurements, either versus the magnetic field or temperature.

Keywords: MSSFs, Co—Ni, Ferrite microspheres, hydrothermally, optical-magnetic features

Key messages: Improving the characteristics of Co–Ni by doping with Ga which will stimulates and activates it’s properties, the new material can be used in industry and biological application as it have high physical properties.

*Corresponding Author: Dr. Munirah Almessiere, Department of Nano Medicine Research, Institute for Research and medical consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. ORCID ID: https://orcid.org/0000-0003-1651-3591 Phone: 0505807292. Email: [email protected]

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4 th Annual Poster Day

IRMC-SRP-2022-03

Graphical Abstract

Kawthar Mogheas, Wasan Alrubaian, Dr. Munirah Almessiere Study the physical properties of Ga doped Co—Ni Ferrite microspheres

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IRMC-SRP-2022-03

Poster

Kawthar Mogheas, Wasan Alrubaian, Dr. Munirah Almessiere Study the physical properties of Ga doped Co—Ni Ferrite microspheres

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Latifah Aljabari^1,2, Laila Albuawadh^1,3, Fatimah Alsaihati^1,3, Dana Almohazey⁴, B. Rabindran Jermy^5*

Developing Zeolite-Mediated nanocomposite for pulmonary drug delivery to treat Cancer and COVID-19

IRMC-SRP-2022-04

Abstract

2College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

3College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia ⁴Stem Cell Research Department, Institute for Research and Medical Consultations (IRMC), Imam

Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

*Email: [email protected]

Background: Virus causes cancer and cancer patients are susceptible to COVID-19 infection. The present study design an effective pulmonary drug delivery system for delivering cancer and antiviral drugs for potential treatment of cancer and COVID-19.

Objectives: Zeolite nanoparticles with high surface area and micropores possess a

remarkable ability to exchange and absorb ions which can be utilized. This study aims to design a polyethylene glycol (PEG) wrapped zeolite-based nano system that can recognize pulmonary acidic environments with a potential to attack by delivering known antiviral (dexamethasone) and anticancer drugs (cisplatin) in slow and controlled manner.

Methods and Material: Zeolite was synthesized using hydrothermal technique using colloidal silica as silica and tetrapropyl ammonium hydroxide as template source. Cp and Dex was functionalized under ice cool environment. Then the formulation was pegylated using lyophilization technique. The nanoformulation was characterized for their surface area (Brunauer-Emmett-Teller (BET)), phase (X-ray powder diffraction (XRD)), thermal stability (Thermogravimetric analysis (TGA)), chemical coordination (Diffuse Reflectance Spectroscopy-Ultraviolet(DRS-UV)), and functional groups (Fourier transform

infraredspectroscopy(FTIR)).

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4 th Annual Poster Day

IRMC-SRP-2022-04

Abstract

To assess their application, drug release pattern dexamethasone and cisplatin was assessed in a dialysis membrane at pH 5.6. As for their cytotoxic affect, MTT assay was conducted on HEK293 and A549 cancer cell lines which were treated with different concentrations (0.00125, 0.0025, 0.005, 0.025) of the nano-formulation.

Results and Discussion: Following synthesis, Ag silicate zeolite nanoparticle formation was confirmed through X-ray diffraction analysis. The TGA study showed 14% template inside the zeolite crystals.. In drug adsorption study, zeolite nanoparticles showed higher affinity to dexamethasone compared to cisplatin. Coronavirus interaction with cell occurs at pH 5.5. The release of dual drugs was performed at such pulmonary infection fusion pH condition of 5.6. The combinational drug delivery study showed higher cumulative release of cisplatin (14%, 9 h) as compared to dexamethasone (2%, 9 h). However, when delivered solely, dexamethasone had slightly higher release (4.5%, 9 h).

Conclusions: A PEGylated zeolite nano-formulation was synthesized using hydrothermal technique for pulmonary drug delivery to treat cancer and COVID-19. The nanocarriers were loaded with dexamethasone and cisplatin and placed in a dialysis membrane to assess drug release. After analysis, zeolite nanocarriers showed promising results in drug delivery in vitro.

Key-words: Dexamethasone, cisplatin, drug delivery, Zeolite nanoparticles

Key Messages: Zeolite-mediated nanocomposite was developed with pH sensitive drug release for potential pulmonary drug delivery.

*Corresponding Author: Dr. B. Rabindran Jermy, Department of Nanomedicen, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal

University, Dammam, Saudi Arabia. ORCID ID: 0000-0002-8698-2820, Phone:

00966599257315, Email: [email protected]

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4 th Annual Poster Day

IRMC-SRP-2022-04

Graphical Abstract

Latifah Aljabari, Laila Albuawadh, Fatimah Alsaihati, Dana Almohazey, B. Rabindran Jermy Developing Zeolite-Mediated nanocomposite for pulmonary drug delivery to treat Cancer and COVID-19

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4 th Annual Poster Day

IRMC-SRP-2022-04

Poster

Developing Zeolite-Mediated nanocomposite for pulmonary drug delivery to treat Cancer and COVID-19

Latifah Aljabari, Laila Albuawadh, Fatimah Alsaihati, Dana Almohazey, B. Rabindran Jermy

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4 th Annual Poster Day

Ahmad Abdullah Bukhamsin^1,2, Mouad Ahmed Tuhami^1,3, Dana Almohazey⁴, B. Rabindran Jermy^5*

Fabrication of Magnetic/SBA-15 Hexagonal Silica and Clay nanotube with Cisplatin nano-composite for potential cancer therapy

IRMC-SRP-2022-05

Abstract

2 College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

3 College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

4 Stem Cell Research Department, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: The advancement of multifunctional nano-drug delivery systems in recent years has attracted huge interest in cancer therapy. Silica and Clay type nanoparticles can be improved for oral bioavailability and target delivery of the drug to the tumor cells. SBA- 15 hexagonal-shaped silica and halloysite (HAL) nanotube clay have unique textural characteristics that can be utilized for targeted drug delivery.

Objective: Our study aims to fabricate and compare cisplatin drug release ability from polymer-wrapped large pore hexagonal magnetic/SBA-15 Silica and Clay nanotubes for potential cancer therapy.

Methods and Material: In the first step, 10% SPIONs was impregnated on SBA-15 and Halloysite clay. Then wrapped with chitosan and functionalized with modest dosages of cisplatin (5% wt/wt). The nanoformulations were then characterized using XRD, SEM-EDX, and TEM. Two nanoformulations' adsorption and drug release ability were studied at tumor acidic pH 5.6 and 6.6. The drug adsorption and release were evaluated using UV-vis spectroscopy.

Results and discussion: The cisplatin and polymer nanocomposite based on silica and halloysite clay was confirmed by XRD, SEM-EDX, and TEM analysis. Cisplatin and chitosan XRD pattern confirms crystalline transformation to amorphous form in both

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4 th Annual Poster Day

IRMC-SRP-2022-05

Abstract

The adsorption study between 15-120h shows a progressive decrease in cisplatin

absorbance on the SBA-15 sample over time, showing successful cisplatin dissolution and effective adsorption on the pores of SBA-15. While in Hal, only a slight adsorption effect is observed till 96h. During this time, a sharp decrease in cisplatin absorbance occurs, suggesting drug adsorption inside the nanotube's lumen. This suggests effective bonding between cisplatin and the hydroxyl group of silica, while Hal prefers external cisplatin adsorption on clay nanotube. Drug delivery study performed using dialysis membrane technique in tumor acidic pH 5.6 and 6.6. SBA-15-based nanoformulation exhibited a controlled release profile below 30% at pH 5.6, which further reduced to below 10% at pH 6.6. In the case of the halloysite clay system, a high cisplatin release is observed in 70% due to the adsorption of the drug at the external surface of the nanotube. However, the delivery of cisplatin reduces to 10% at pH 6.6.

Conclusion:Our study developed SPIONs/silica and SPIONs/Hal-based nanoformulations for cancer treatment. XRD, SEM-EDX, TEM, and UV-vis spectroscopy were used to investigate drug

functionalization and nanocomposite's textural and chemical characteristics. According to our findings, cisplatin adsorption and release patterns are altered based on the nanocarrier's shape and texture, such as its hexagonal shape and clay nanotube. SBA-15 exhibits slow and sustained cisplatin release as opposed to Hal, which exhibits high cisplatin release. Conclusively, SBA-15-based nanoformulation can be used to treat tumors for a prolonged period, while Hal can be used for rapid-release treatment.

Keywords:Magnetic nanoparticle, mesoporous silica, halloysite clay, SBA-15, cisplatin.

Key message:Multifunctional drug delivery system developed for targeted cancer therapy.

*Corresponding Author:Dr. B. Rabindran Jermy, Department of Nanomedicine Research, Institute for Research and Medical Consultations (IRMC), Imam Ab

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