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LA2UOOSPASK DVRIIU G.f:IERAL AHAES!BESIA Il CA�
A tbMd•
uellte4 ill partial flll.t1llleat
ot the nq�t• tor t1ut depoee ot Doc\or ot Pbiloeoptq ill Vetert.rJ Sci
at Nu 7 11D1werait7
It is a pleaave to ackaowledg!e the encovaaeaent aad actn.c. whicb were givea to • b7 Dr. D.A. 'l'itehn ancl Profeaeor E.O. J'ieldea.
Dr. R.E. Rawsti'Oil ad Dr. C.S;iV. Reid •• aleo helped b7 d.iacwlaiq results. Mr. R. Faulcliq haa .ai.Gtal.aed the electroDic aDd anaeath.etic apparatu ancl Jlr. G.H. luru waa rtNIJ)ODSible for the plaotogra!'h7.
l aa gatetul to Mr. I.A. ReJDOlda, Mr. B. Barnett, Hr. D.W. Dellow
aDCl K1aa L. aera-Buge tor tecbnical aaaiatuce aad to Mr. L. Jenki.Da aD4 the atatf ot the Maese7 tJDiYera1t7 libra17 for their help with nfereac••·
I also witah to record rq thuka to a, colleaauea 1a the De,.n..nt of Veteri.nal7 Clinical Sciences tor their co-operatioa, ac:ourap11e11t aad helpful cri tieiaa.
IUa May Soo tYJ"td the theaia.
Pap
I IltTRODtJc-11011 1
II RMIW OF 1!1:&: LITERA'l'\JRE
AND
AN INTJlODUCTIOlf TO TUP OILIN 2
1.
A
Coaa14enU.oa ot tu Stnotural. u4 J\mctloaalBaaia of LarJil80apua 2
(a) the poae anatOilJ of the 1...,_ 2 (�) !be 1111Utl"fttioa of the 18J'111X aDd reo.ptOI'
ar- whioh _, be laTolYecl 1a the l...,._seal
reflex �
(1) Motor ianel"Yatioa �
(11) !be atternt path•.,. '
StUnalatl• of the aaeal aucoaa,
soft palate aa4 pbaJ'1JIX 6
Stiaulatioa of the eplslottla aa4
1...,.. 10
Stial.atla of the traoheo-broachial
tree 12
Stiaulatioa of the ab4olt1ul Ylaoel'tl
alld 4iaphrap lit
(o) � closure aJMt ita ftaactiOA 1'
a. The Cllaical Slpif1oaaoe of Lai'JBIOIIpaa 18 (a) 'J.'ba laportaaee of lar7D8oapaaa an4
bronohoa� 1a MD aacl aai•la 19
Ut) Ooacl1 t1oiiAI Wl4er which l.ar1Dgoapa• oocura 20 (c) Metho4a suueated tor preyetiq
l.arJap•pa•
nx liXPIIUMER'l'AL PBIPARA'l'IONS .ilHPLOnD AND THE ACTIYift OF BB LA tNGEAL MUSCLES AlfD THE DIAPllRAGII DVRIIG QUIR RESPIRATION AND ItfFLATION AND DEFLATIO. OF 'l'U
LmfGS �
1. ftae i:l:periMDtal Prepara,loa 21t
(a) Maiateuaoe of aaaeatheela witb
ebloraloee �
(lt) The decerebrate pNpuetioa Z'l
(e) MllillteDAilft of aaaeatheala with other .....
2. Metboda Veed to Ia.eatlcate the Ao\1Yitr of �
� Muaele•
(a) A hia\ori al. ooaa14eraUoa of
eleoti"OIIlOS"JSb7 ,
<t•> 'l'ecbD1quea tor elect.roa�JopoaphJ )2 (o ) �•elopllellt of a noor41.J18 techalque Jlt (4) Dltt1oult1ea enoouatered 1D obtalatDa a
aatlafaotor,r reoor4 ''
(e ) Seotion 8114 atiaW.atloa ot aenea Y1 ,. ReaW.ta ot Ia••••laatiou illto tile Reatiaa
Aotirtt7 ot the Diapbl'ap an4 the Iatrlulo
� Muol ..
... 'l'lle Aot1ntr ot the Dtaphrap aa4 s... ot Ule Iatl'iuio � ol.. 4vllla Iatlatioa
u4 Detlat1oa of the IAuap
38
(a) IatlaUoa ''
(') nenatioa "
,. A D1aouaioa of tlae Recorda Obtaiaa4 cluriq Qtaiat eapf.ntioa aad oa llltla\loll • DatlaUoa
of the lAaap "<>
(a) A.otlft.tJ 4urlaa calllet napll'ati ltO Ut) Ao•t•ltr � 8aia\allle4 1Dtlatloa
Gf the lup .. ,
(o) Aoti'rit7 4unq •1Dbiu4 clefiatioa ot the lap
(cl) Coaoluaioaa d.ran troa electroiiJOsraplalo
rnon. obtaillecl 4w1Ac 1afiat1oa aa4
cletlatioa ot the lup
IV TIE RESPONSES OF TB LARYHOSAL NVSCL£$ AND DIAPilRAGIC '.fO BCHAHICAL Aim CBEMICAI. S'riMULATIOII 07 '1'HI
RESPIRATOat ftACf
1. &xpei1.Mau to ReooM the a..-.. of tbe
� llaaacle• and Map!uoa .. to IIHJaaaioal ..
CbMioal SUalaU.oa of the hepifttoQ '�'not aacl the lfteou of s-. otiMr Dnae oa Da ...
Paae
Rea:pouH 1t7
(a) Dae efteote of 8Mbaaioal. atiaalati• of
the p�aarJJ�x, aott palate, l..ar7U ud traohea 1t7 0•) iJhe etteou ot •JI'811Da the� u4
aatertor l..arpx with Yol.atile .. �Uo
.... ,.
(o) 'D1e effect. ot the iall-laUoa of 'fOlatile aaa .. thetlo ap��ta, MmDi•tencl b7 Mak, iato the iataot rupiratoq van
(4) !be etfeota ot the paaaap of YolaUle anaeathetlo ac-ta iato 1aol.ate4 ar ... of the respirat017 traot 1 the uaopbai'JD aad l.al7ul the U.che&l the clietal uaoh .. aad lap
(1) Puaap of YOlatUe uuathetlo apau throqb the aaaoplaarJax and l.AJ7U
(U.) Puua- of wlatile aaeathetlo ... throqta Ul taolate4 ti'&Oheal ... , with Der'Ye &M �oo4
npplJ' utan
(W) ...,. of YolaWe -•thetlo aanta lato tM d1aUl v.a.a u41 ....
(e) !breaho14 of attalaU.oa ot 1�•
''
'' Yl
V
(f) !he effeo�e of atropllle oa the reactioa to att.alatiola of the reeplrat017 tra•t
<c> The effeota ot local analgesic apra;rilaa of the p� aact aaterior 1.a17U oa
the stiaulatioa of larfll80•pa• 1»7
�latile anaee�e�lo asea\8
(ll) The effeo� of aWCBM�oa1• oa the etilhlla�1e of larJI&SOapa• u4 oa the aot1Yi\7 of the oriooth1J'o14 IIUCle aacl 4iaphl'a ..
(1) !be effect of thiopea�ou OD tile eUal.atioa ot the reapil'ato17 traat 1»7 �latile
aaaea�he�lc a,.Jlte
z. Dla eiOA ot the Experilleatal Reaul ta Reported 1D Chaptv IY
(a) Mechardoal ett.l tioa
(b) Spra71D« the phaJ7DX and l8.1'JDX d.tb anaesthetic aseata or ealiAe
(c) IDbalatioa of anaesthetic aceata to the lataot resp11'a�o1'7 traot
(cl) 'Dle effects of .olatile anaesthetic apate oa l8olated areas of the reapil'atOJT
traet
(e) ftl'eeholcl of atl•latioa
(f) !he effeota of a�ropilae
<a> � effect ot aaalceato epraJ•
(ll) !be etteota of .... le r laxaata (1) !be •ffecat of bltvatea
THE IFfiC'l'S OF CVT'l'II«J N ES IBICB MA f BB IIIYOLVED IR THE LARtiGEAL RJ!IJ'LIX • AJID SOMI RESULtS OP' 'l'DD
ftiMULAflOI
1. llcperiaeata to Reool'd. the Bffecta of CUttiq fterYea Which � be IaYo1Ye4 1ll tbe � Renax eel 8olle lff ta of '!bei.r Sti�t1oa
,. ..
6,.
67
68
68 10 71
1' 75 78 79 8o 82
8)
(a) !he effeota of euttillc tu il&tei'Ul. Ualloll of \he n.-n.or laJ"11laeal aen ..
('b) 'Dae effeots of outtlas U�• recvreat l.arJDpal ...
(o) 1'be effeota of a perillnnl blook of the tria8111Ml aerYaa wf.\h looal aaalpeio aolutioa
(cl) The afteota of outtiq tM cerdoal ••1'1•
...
(e) Sti.U..tloa of aenea thoqht to fol'W part
., as
of the lai'JilP&l renex patbwa,. 87
2. DS.aouaeioa of tb.e Sffeota of C.ttiq or StiiNlatiq lien .. Which Ma7 be IaY01Ye4 ill the I..ar�
�na �
VI 'l'JIE EFJ'ECTS Of Ilft'RAVENOUS IMJECTIOJIS OF A SOLU'IlOff OF &'fliER . A COMPARISON WI'l'H 'l'JIE EJTECl'S OJ' IMJECJ.'IIfCI A SOLll'l'lOJ OF HYDROGER CTANIDI
1. lxperiaeata to Reaorcl the Sffeo-. of the Iatr&Yenou Iajectioa of Solutiou of Ether aa4 HJVosea CJU14e
(a) Dae effect• of iAjectiDa aaaeathetio
eolutioaa aa4 •111le into \he fe1101'8l.
••ill
('b) A coaparieoa of �· affeota of tbe iatraYell0\18 il&jeetioa of aolutiou of ether aad h,rdropa GJUide
2. l)S..ecueioa of the Renlta of ixperi.Mata oa the IatftYeana Ia3eotioa of Solutioae of ltlleJ' aa4
9.5
H;rdropa C,.ai4e 102
fii CJINDAL SUMMARY AND COHOLUSIOIS 1C11
11, APPIRDIX 1
TABLE OJ' naVRES
fta• 1 DiaSJ"UU ot the Lar1U
Fis• 2 The Cartilage& ot the Cat •a Lv7JU1
J'1c• ' The Intriaeio Lar7aseal Mwsclea ot the Cat
1'18• 4 Diagraa to ehow the Mecbaa1• of I.arJBaeal Cloaure
J'ia. ' Dlasru to ahow the Adductor Aotioa ot the CrioothJroid Muole
ft.g. 6 Dia..,.. to ehow the LeYel ot Traueotioa of the Neuraxia 1a a Decerebrate Preparatioa prepared br llltercollioular Sectioa
J'i.g. 1 DiaFU to ahow the LeYel of Decerebratioa ot the Neuraxia 1a the Ischaetlic Tecbaiql&e
J"ig. 8 Block Dt.agru of the Recorcling Syst• UMd tor ileotl'orl.7os:ra�
J'1 • 9 The Etteet ot Exceae1Ye Iatenait7 ot the Oacilloacope Trace
Fls• 11 lteet1q e111 Aot1rit7 ot the Diapbl'ap aacl Iatriaaic LaJo7ageal sole• of Uae Cat
ft • 12 A R 01'4 of Iatrathoraolo Pl'eenre Su.perillpoee4 oa tile DiaphJ'a tlo -a Sipal
ftS• 1' the Etteota ot Luaa Ianatioa 011 the Act1Y1t7 of the
Di.aphN .. &llcl Iatr1Da1e Lar7111eal Mwtol .. ot the Cat fts• 14 'llle Etteota ot Luq Defiatioa oa the Aot1Yit7 ot the Diapbrap ud Iatriulc LaJo7ageal ._olea ot the Cat
F11• 16 'l'he Reapoue of the Diaphrap and the Cr1coth7ro14 Muscle
to Meohanical Stiaulat1oa of the LarJilX u4 'l'raohea
1'11• 17 The Reapoaae of the Dorsal and Lateral Cr1coal"1teD.Oid Mucl•• •hea the PharJBx ead Anterior Laryu are Sp!'87ed ri. th Ether
i'is· 11 A Collpariaon of the Eftecta ot SprllJiag the / PbarJBX and Laryax with Saliae, Ether, aacl Balothalle
1'11• 19 The Etteote of A4min1 terills Ether aac! Halothane by Maak to the Intact Reapiratorr Tract
Fig. 20 The Poeitiou of Tracheal Caanulae 1n SKperiaental PJ"eparatiOIUI
Fie. 21 '!be Ettecta ot ExpoeiJaa the Ieolate4 lfaeopbaey'Dx and Lai"JDX to lther, Halotlaaae aad Metholqfiurane
n.a. 22 'l'be Etfecta of Paaeiag Ether Vapour Throup an Iaolated
Tracheal .Se-at
1"11• 2' Tbe Effeota of Admi nt steriq Ether Vapour to the Distal 'h'achea and Lurlp
I'll• 2Jt A ooapariMa ot the Effect• of IJalothaae and Methoxyflurane,
Aailliatered. to the 'traeh.. aad tap
Fie• 2' !be Efteate of Iahalatioa of tncreaeiag Conoentrationa of
Ether Vapov
n,. 26 !be Watera' SJSt .. tor the A4!1dotatratioa of lfthalat101l Au .. thetioa
n.a. Z'l ftle Stteata of IDhalatioa of Iaorea.aiq Conoentratioaa of .Ether Vapou whea Ether ia Inhaled Continuouq
1'11• 28 !M Effeota ot IAhal.atioa ot Iaereuiag Conceatntiou ot
� ... Vapour with the Vaporiser MailltaiDecl at a Coaataat T.-peratun
n.a. 29 4ftle Etfecta ot Atrop1De oa tbe StiJI\ll.atioa of I.ar7Daoapua '-1 Ether Vapour
n.a. )0 fte Ufecta ot SpraJiDS the Pharpx aacl Aaterior Lar1JIX with Looal. Aaalpa1o 1D a cat with a Treolleal Cauul.a
Fil• 3]. The Etteou of SpraJiA& the Pbal"JU ad Aaterior Lar7U with Looal Aaalpato ill a Cat whoee ReapiJoetoey Tract 1a lJataot
fta· :52 CoapariHD of a MoYellellt Artifact clurbl Artitioi.al
piratioa •1 th the eas troll the Diaphrap 1a Spontaneou ReapiratiOA
Fig. 33 '!be J:tfeot of Suxaaetboaiua on the StiiNl tioa ot Lal")'llaoepqa, 1.
n.,. )4 !be Effect of Sua•ethoaiua OJl the Stilhll.atioa ot
Lar7agoepa•, 2.
file '' 'ftae Eftect of Thiopeatoae OD the StiaNl.atiOD of Lai"J1180apaaa
Fis. :56 Stial.aUon of the NasoplaaJ7a:x and Lar)'u' 1»1 Ether after Outtiq the llatenaal Braaa ot Both Superiol' � ...
n.a. )1 Stilnalatioa ot the lfuopbai'Ju aacl IAli'Ju after C\attiq
tbe boUHat LarJD18al hnM
fie. ,a
fte Uteota ot a Periaaural ll.ook of the M,..tul lerYu after Cuttina tile I.lltanal 8ralaob of ltotla periOI' LarJapal Ha ...1"11• J9 'lbe feoU of O.ttiDI tba Cani.oal Vapa lfenea
1'11• 41 Stiln&latloa of .Dtapbrapatio Aot1Yit7 en the KaaopbaJ7U, LarJDX, Trachea ancl Lulap an exposed to Ether Vapour
ns. 42 Dlasraa llhow1q the luenatioa of tile Carotid Bocl7 bel euotu stmu. 11a tu eat
1'1&• 43 Dle Ufeota of Iatraveaou Iajeotioa of Ether aad Balothllae Solutiou
fta• " 'l!a4t Etfeota of IatnYeaou Iajeotioa of &tber aa4 BCN Solut1ou, 1.
1'11· '' the &fteota of Intravenoua IaJectioa of Ether and BClf Sol.utioaa, 2.
Pie• lt6 'lbe Etfeota of IatraYnou lDjeotioa of hber aad HCI SoluUoaa, '·
ne. '+7 !he Effects of IatraYeao Injection of Ether and BCI Solutioae, 4.
Fie• ..a 'ale Effeota of Iatl'aYeaoua Illjeotioa of all r and BCI Solutioaa, '·
n.,. 49 !be Ufeota of Iatl'aYeaoue Iajeotioa of .Ether and CN Solutiou, 6.
fts• , '!he Etfeota of llltreYeaou IAJeotioa of ltlaer and
ION
Solutiou, 7•
Fll• 51 !be Ufecu of Iatraye ou IaJectioa of . er aacl BClf Solu\iou, a.
