• Urinary tract infections (UTIs) are one of the most common bacterial
infections acquired worldwide (Laupland
et al., 2007).
• Escherichia coli (E. coli), the pathogen most frequently implicated in UTIs, is becoming increasingly resistant to
available antimicrobials (Nicole, 2008).
• Whilst prevalence rates for urinary E.
coli resistance have been reported in Australia, to our knowledge there are no published incidence data.
• Available data do not allow for
adjustment of variables like age and sex. There are also no data comparing resistance patterns for healthcare
associated and community acquired UTIs.
Study One
This study will use a population-based retrospective cohort design.
• Urine samples of Australian Capital Territory (ACT) residents processed at ACT Pathology will be
retrospectively reviewed over five years to determine the cumulative incidence and antimicrobial resistance trend of urinary E. coli isolates using the population of the ACT as the denominator.
• Only the first episode of antimicrobial resistant E.
coli UTI per patient per year will be included as incident cases.
Study Two
This study will use a cross sectional design.
• Urine samples from the Canberra Hospital processed by ACT Pathology for the five year study period will be classified as either community or healthcare-
associated samples.
• The prevalence of antimicrobial resistance in community-acquired and healthcare-associated urinary E. coli isolates will be compared.
Laupland, K., Ross, T., Pitout, J., Church, D., & Gregson, D.
(2007). Community-onset urinary tract infections: a
population-based assessment. Infection, 35(3), 150-153.
Nicolle, L. E. (2008). Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis. Urologic Clinics of North America, 35(1), 1-12
Images from www.googleimages.com
Thanks to Professor Peter Collignon (Director of ACT Pathology), Dr
Anindita Das and staff of ACT Pathology.
The aims of these studies are to:
1. Evaluate the incidence and
antimicrobial resistance trend of
urinary E. coli isolates over a five year period.
2. Compare the prevalence of antimicrobial resistance in:
• healthcare associated urinary E.
coli isolates and
• community acquired urinary E.
coli isolates.
The study findings will provide healthcare providers in the ACT with incidence and
prevalence data on UTI E. coli resistance to help inform treatment guidelines. They will also provide research data for ongoing
surveillance of antimicrobial resistance in urinary E. coli in Australia.
BACKGROUND
Antimicrobial resistance among urinary tract infection isolates of Escherichia coli in an
Australian population-based sample
Oyebola Fasugba (MPhil student)
1, Anne Gardner
1, George Mnatzaganian
1, Brett Mitchell
1,21Australian Catholic University 2Avondale College of Higher Education
CONCLUSION
To our knowledge this is the first antimicrobial
resistance population-based cohort study in Australia and provides new knowledge on the incidence and
prevalence of urinary E. coli resistance in the hospital and community.
