The Multifaceted Role of Curcumin in Advanced
Nanocurcumin Form in the Treatment and Management of Chronic Disorders
Priti Tagde, Pooja Tagde Fahadul Islam,Sandeep Tagde, Muddaser Shah, Zareen Delawar Hussain
Md. Habibur Rahman, Agnieszka Najda, Ibtesam S. Alanazi, Mousa O. Germoush,Hanan R. H.
Mohamed,Mardi M. Algandaby,Mohammed Z. NasrullahNatalia Kot,Mohamed M. Abdel- Daim
Abstract:
Curcumin is the primary polyphenol in turmeric’s curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but has poor solubility and low bioavailability. Objective: To improve curcumin’s bioavailability, plasma concentration, and cellular permeability processes. The nanocurcumin approach over curcumin has been proven appropriate for encapsulating or loading curcumin (nanocurcumin) to increase its therapeutic potential. Conclusion: Though incorporating curcumin into nanocurcumin form may be a viable method for overcoming its intrinsic limitations, and there are reasonable concerns regarding its toxicological safety once it enters biological pathways. This review article mainly highlights the therapeutic benefits of nanocurcumin over curcumin.
Conference / Journal Link:
https://www.mdpi.com/1420-3049/26/23/7109
DOI:
https://doi.org/10.3390/molecules26237109
