The lymphatic system
and Immunity
Bahan kuliah
Tujuan pembelajaran
• Mengidentifikasi & menjelaskan komponen utama
sistem limfatik
• Menjelaskan definisi infeksi, patogen dan antigen
• Menjelaskan definisi getah bening dan bagaimana
sirkulasinya dalam tubuh
• Menjelaskan perbedaan innate (nonspecific)
defenses & adaptive (specific) defences
Lanjutan tujuan …..
• Membedakan “cellular immunity” dan “humoral immunity”
• Menjelaskan peran limfosit dalam respons imun
• Menjelaskan tipe dan fungsi sel T
Sistem limfatik vs Imunitas
•
Peran utama menjaga kesehatan tubuh
•
mikroorganisme penyebab penyakit :
patogen
•
Setiap patogen mempunyai cara hidup yg
berbeda, menyerang tubuh dengan cara
spesifik
Sistem limfatik vs sistem imun
•
I
mmune system– Protects the body
against • Bacteria • Viruses • Fungi • Toxins •
• Lymphatic system
– Works with immune
system to remove disease-causing agents
– Organs
• Thymus
Patogen disekitar kita
The Lymphatic System
• Network of connecting
vessels
– Collects fluid (lymph)
between cells and returns it to
bloodstream
– Picks up lipids from
Sistem limfatik
•
Sel, jaringan, organ yang bertanggung
jawab thd pertahanan tubuh
•
Terhadap : environmental hazards (various
pathogens) & internal threats (cancer
cells).
•
Limfosit : the primary cells of the
lymphatic system
Komponen sistem limfatik
• Limfa : cairan getah benih dari plasma darah ()
28-10
Lymphatic Pathways
• Lymphatic capillaries
– Extend into interstitial spaces
– Permeable, thin walls pick up fluid, now lymph
– Delivers lymph to lymphatic vessels
• Lymphatic vessels
– Deliver lymph to lymph nodes
• Cells in nodes can remove pathogens from
lymph and start an immune response
– Leaves nodes through efferent lymphatic
vessels Lymph
Lanjutan sistem limfatik
– a network of lymphatic vessels, often called
lymphatics, which begin in peripheral tissues and connect to veins
– Jaringan limfoid dan organ limfoid di seluruh
tubuh
Peran sistem limfatik
•
Fungsi utama : produksi, pemeliharaan dan
distribusi limfosit
•
Jaringan limfoid (tonsil), organ limfoid
(spleen & timus), memproduksi &
menyimpan limfosit
imunitas
•
The ability to resist infection and disease
Kapiler limfatik
Peran limfosit
Mengeliminasi :
• invading pathogens (such as bacteria or viruses),
abnormal
• body cells (such as virus-infected cells or cancer
cells),
Lanjutan limfosit
•
Utk pertahanan efektif, limfosit harus
mendeteksi & mencapai tpt terjadinya
infeksi
•
Lymphatic vessels
Immunity
•
The ability to resist infection and disease
•
Klasifikasi :
– Innate immunity
– Adaptive immunity
Innate (non-specific) defenses
•
Mencegah, menghalangi & membatasi
penyebaran mikroorganisme
•
Terdiri dari :
– Physical barierrs - komplemen
– Fagosit - respon inflamasi
– NK cells
– interferon
Peran porforin
Komplemen
Respon imun adaptif
Pengenalan antigen
MHC
Struktur & Fungsi Antibodi
Overview
respon
imun
28-40
Summary
The lymph system is composed of pathways known as lymph vessels. In addition to the lymph vessels, the organs of the lymphatic system include lymph nodes located throughout the body, the thymus in the
mediastinum, and the spleen located in the LUQ.
Lymph is the body fluid found between the body’s cells. It circulates through the body via lymphatic capillaries, lymphatic vessels, lymph nodes, lymphatic trunk,
Summary
Infection is the presence of a pathogen in or on the body. A pathogen is a disease-causing agent, and
antigens are foreign substances within the body that may or may not cause disease.
The nonspecific body defenses include species resistance, mechanical and chemical barriers, phagocytosis, fever, and inflammation.
