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THE EFFECTS OF ADDING SODIUM BICARBONATE INTO LOCAL ANESTHETIC AS BUFFERING AGENT.

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The Effects Of Adding Sodium Bicarbonate Into Local Anesthetic As

Buffering Agent

HON HAN

WONG - 1601101023028

ABSTRACT

Local anesthetic, a common drug that always used in medical field to

reversibly block the nerve impulse conduction when applied to a particular area of

the body. The aim of this research was to study the effects of local anesthetic that

had been buffered by sodium bicarbonate.

This research was literature study that based on reading, interpreting and

composing information from various references, including journals, textbooks,

and websites.

The study shows that buffering local anesthetic can increase the pH of the

solution and increase the number of available uncharged molecules of local

anesthetic that are functioning to block the generation and propagation of nerve

impulse.

In conclusion, the buffered local anesthetic is able to decrease the pain

during injection, decrease the time of onset and provide a better anesthesia effect.

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vii

Efek Penambahan Natrium Bikarbonat Ke Dalam Anestetik Lokal Sebagai

Agen Buffering

HON HAN

WONG

1601101023028

ABSTRAK

Anestetikum lokal adalah obat yang sering digunakan dalam bidang

medis untuk memblokir konduksi impul saraf secara reversibel bila diaplikasikan

ke daerah tubuh tertentu.

Tujuan dari penelitian ini adalah untuk mempelajari efek dari

anestetikum lokal yang telah diberi larutan bufer natrium bikarbonat.

Penelitian ini merupakan studi literatur yang didasarkan pada membaca,

menafsirkan dan menyusun informasi dari berbagai referensi, termasuk jurnal,

buku dan situs web.

Studi ini menunjukkan bahwa penambahan larutan buffer pada

anestetikum lokal dapat meningkatkan pH larutan dan meningkatkan jumlah

molekul bermuatan dalam anestetikum lokal yang berfungsi untuk memblokir

listrik dan penyebaran impul saraf.

Kesimpulannya, penambahan larutan bufer pada anestetikum lokal

mampu mengurangi nyeri selama penyuntikan, mengurangi waktu mula kerja dan

memberikan efek anestesi yang lebih baik.

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