Pembuatan Suspensi Hidrokortison Asetat

LAPORAN RESMI PRAKTIKUM LAPORAN RESMI PRAKTIKUM

TEKNOLOGI DAN FORMULASI SEDIAAN STERIL TEKNOLOGI DAN FORMULASI SEDIAAN STERIL

Percobaan IV Percobaan IV PEMBUAT

PEMBUATAN SUSPENSI AN SUSPENSI STERIL HIDROKOSTERIL HIDROKORTISON ASETARTISON ASETATT

Disusun oleh: Disusun oleh:  Nama

 Nama :: Alifatul Lu’lu’ahAlifatul Lu’lu’ah  NIM

 NIM :: 13/ 346102/ F13/ 346102/ FA/ 095A/ 095!! "

"oolloonn##aann//$$eell :: IIII/ / %% &

&##l 'l '(a(a))titi)u)umm :: *a*a+u+u, 2, 2! ! AA--(i(il 2l 2001616 D

Doosseenn :: DD((. . **ee((..nnaatt. . **oonnnn  MMaa((ttiieenn, , MM..ii.. A

Assiisstteen n aa##aa :: Asisten

Asisten $o(e)si$o(e)si : : lf(ialf(ia

LABORATORIUM TEKNOLOGI FARMASI LABORATORIUM TEKNOLOGI FARMASI

DEPARTEMEN FARMASETIKA DEPARTEMEN FARMASETIKA

FAKULT

FAKULTAS AS FARMASIFARMASI

UNIVERSITAS GADJAH MADA UNIVERSITAS GADJAH MADA

YOGYAKARTA YOGYAKARTA

20! 20!

PER"OBAAN IV

PEMBUATAN SUSPENSI STERIL HIDROKORTISON ASETAT

A# T$%$an

A#a( mahasisa mam-u memahami an mem+uat sus-ense ste(il hi(o)o(tison asetat.

B# A&a' (an Ba)an

Alat: %ahan: *  Ne(aa ele)t(i)  * ial * 'i-et u)u( 1,0 mL * '(o-i-et * Auto)laf  * 78en * %otol tim+an# * eno)  * 'i-et tetes

* Mo(ti( an stam-e(  * "elas u)u( 

* "elas -en#au) 

* aan -et(i

* %ea)e( #lass

* i(o o(tison asetat

*  Nal * 'olso(+ate;0 * M Na * %en<l al)ohol * A=ua "# LANGKAH KERJA For+$&a */ tia- ml men#anun#

i(o o(tisone asetat 25 m#

 Nal 9 m#

'olso(+ate;0 4 m#

M Na 5 m#

%en<l al)ohol 0,9 >

A=ua -.i a 1 

us-ensi an# i+uat se+ana) 60? fo(mula. "ara Ker%a



iste(il)an alam autola8e 121°  selama 15 menit +e(sama a=ua 

o(tisone asetat,Nal,'olso(+ate;0 iste(il)an )e(in# alam o8en 160°  selama 1 @am 

Di+uat sus-ensi alam )ota) ase-tis / LAF a+inet: aB Nal ila(ut)an en#an se+a#ian a=ua



Ditam+ah +en<l alohol

+B o(tisone aetate itam+ah -olso(+ate 0



Diam-u( homo#en

B am-u(an +B itam+ah en#an la(utan M;Na



Diau) homo#en

am-u(an B itam+ah en#an la(utan aB an sisa a=ua



Diau) homo#en



Dimasu))an )e alam 8ial 10 mL



Ditutu-

)ea-

Diamati sus-ensi an# te(@ai



Di+e(i eti)et



Dila)u)an u@i ste(ilitas -enum+uhan mi)(o+a -aa meia a#a(B

Meia a#a( iin)u+asi



Diamati satu ha(i an satu min##u setelah -em+uatan la(utan sus-ensi D# DATA PER"OBAAN

# Pen,+ban-an $n'$. /0 +L &ar$'an $1en, (,&eb,).an 034

* i(o o(tisone asetat : 25 m# ? 60 C 1500 m# C 1,5# ; Nal : 9m# ? 60 C 540 m# C 0,54# *'olso(+ate;0 : 4m# ? 60 C 240 m# C0,24# * M Na : 5m# ? 60 C 300 m# C0,3# * %en<l Al)ohol : 0,9> ? 60 C 0,54 ml

* A=ua -.i a 60 ml

'em+uatan sus-ense ile+ih)an 10> untu) men#antisi-asi )ehilan#an 8olume saat  -em+uatan. Dile+ih)an 10> men@ai 55 mL teta-i untu) memuah)an i+uat 60mL.

2# Pen-a+a'an Ha,&

olume 8ial C 10 ml umlah 8ial C 5 +uah @i )e+oo(an C &ia) +oo(  Ea(na C -utih susu

enis sus-ense C eflo)ulasi  - C !

&ia) te(+entu) a)e

Den#an -en##o@o)an (in#an muah te(is-e(si )em+ali

&ia) muah

men#ena-LABORATORIUM TEKNOLOGI FARMASI UNIVERSITAS GADJAH MADA

 No. 3 2! A-(il 2016

'(o: &uti 20 tahunB us-ensi i(o)o(tison Asetat

asil foto

asil ste(ilisasi +ahan asil sus-ense imasu))an )e 8ial

'enutu-an 8ial 'en#ee)an - -C !B

'en#amatan ha(i )e;! tia) aa mi)(o+a 'en#amatan ha(i )e;2 tia) aa mi)(o+a 'e(hitun#an la@u seimentasi

Ea)tu menitB o mB ∆

0 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 5 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 iB 0,4 iiB 0,3 iiiB 0,2 i8B 0,2 8B 0,2 10 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 iB 0,4 iiB 0,3 iiiB 03 i8B 0,2 8B 0,2 15 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 iB 0,4 iiB 0,3 iiiB 0,3 i8B 0,2 8B 0,2 30 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 iB 0,5 iiB 0,6 iiiB 0,6 i8B 0,5 8B 0,2 45 iB 3,2 iiB 3,2 iiiB 3,2 i8B 3,2 8B 3,2 iB 0,5 iiB 0,6 iiiB 0,6 i8B 0,6 8B 0,2 60 iB 3,2 iiB 3,2 iB 0,! iiB 0,!

iiiB 3,2 i8B 3,2 8B 3,2 iiiB 0,6 i8B 0,6 8B 0,2 olume -en#ena-an Ea)tu 0 menit FC ∆ H   Ho = 0 3,2=0 Ea)tu 5 menit FC ∆ H   Ho = 0,4+0,3+0,3+0,2+0,2 5 3,2 =0,0875 Ea)tu 10 menit FC ∆ H   Ho = 0,4+0,3+0,3+0,2+0,2 5 3,2 =0,0875 Ea)tu 15 menit FC ∆ H   Ho = 0,4+0,3+0,3+0,2+0,2 5 3,2 =0,0875 Ea)tu 30 menit FC ∆ H   Ho = 0,6+0,5+0,5+0,6+0,2 5 3,2 =0,15 Ea)tu 45 menit FC ∆ H   Ho = 0,6+0,5+0,6+0,6+0,2 5 3,2 =0,1563 Ea)tu 60 menit FC ∆ H   Ho = 0,6+0,7+0,7+0,6+0,2 5 3,2 =0,175 E# PEMBAHASAN # Pe+er,aan Ba)an a# H,(ro "or',one Ae'a'

233276 %M 404,50

i(o )o(tison asetat men#anun# tia) )u(an# a(i 9!,0 > an tia) le+ih a(i 102,0 > 233276 ,ihitun# te(haa- <at an# telah i)e(in#)an

'eme(ian : se(+u) ha+lu(,-utih hin##a -(a)tis -utih,tia) +e(+au,mele+u(  -aa suhu le+ih )u(an# 200°  ise(tai -e(u(aian.

$ela(utan : tia) la(ut alam ai(,su)a( la(ut alam etanol an )lo(ofo(m. Anonim, 1995 B  +. Na'r,$+ K&or,(a

 Nal %M 5,44

 Nat(ium )lo(ia mem#anun# tia) )u(an# a(i 99,0 > an tia) le+ih a(i 101,0 > Nal ihitun# te(haa- <at an# telah i)e(in#)an.

&ia) men#anun# <at tam+ahan.

'eme(ian : ha+lu( +e(+entu) )u+us,tia) +e(a(na atau se(+u) ha+lu(  -utih,(asa asin.

$ela(utan : muah la(ut alam ai(,sei)it muah la(ut alam ai( meniih,la(ut alam #lise(in,su)a( la(ut alam etanol.

 Anonim, 1995B c# Po&5orba'e*60

'olio)si etilena 20 so(+itan monooleat

'olso(+ate;0 aalah este( oleat a(i so(+itol an anhi(ia an#  +e()o-olime(isasi en#an le+ih )u(an# 20 mole)ul etilena o)sia untu)

tia-mole)ul so(+itol an anhi(ia so(+itol.

'eme(ian : ai(an se-e(ti mina),@e(nih,+e(a(na )unin# mua hin##a o)lat mua,+au )has lemah,(asa -ahit,an han#at.

$ela(utan : san#at muah la(ut alam ai(,la(utan tia) +e(+au an tia)   +e(a(na,la(ut alam etanol,alam etil asetat,tia) la(ut alam mina) 

mine(al.

 Anonim, 1995B (# "arbo75 Me')5& "e&&$&o$+ Na'r,$+

"a(am selulosa )a(+o)si metil ete( nat(ium

$a(+o)si metil selulosa nat(ium aalah #a(am nat(ium a(i -oli)a(+o)si metil ete( selulosa,men#anun# tia) )u(an# a(i 5,5 > an tia) le+ih a(i 9,5 > nat(ium NaB ihitun# te(haa- <at an# telah i)e(in#)an.

'eme(ian : se(+u) atau #(anul,-utih sam-ai )(em,hi#(os)o-i) 

$ela(utan : muah te(is-e(si alam ai( mem,+entu) la(utan )oloial,tia) la(ut alam etanol,alam ete(,an alam -ela(ut o(#ani) lain.

 Anonim, 1995B e# Ben85& a&.o)o&

!0 %M 10,14

%en<il al)ohol men#anun# tia) )u(an# a(i 9!,0 > an tia) le+ih a(i 100,5 > !0

'eme(ian : ai(an tia) +e(a(na,+au a(omati) lemah,(asa mem+a)a(  ta@am,meniih -aa suhu 206°  tan-a -emu(nian,net(al te(haa- la)mus $ela(utan : a#a) su)a( la(ut alam ai(,muah la(ut alam etanol 50 >,+e(am-u( en#an etanol,ete(,an )lo(ofo(m.

 Anonim, 1995B 9# A:$a 1ro ,n%ec',one

Ai( untu) in@e)si aalah ai( sulin# se#a( an# isulin# )em+ali,iste(il)an en#an a(a ste(ilisasi A atau .

'eme(ian: )easaman;)e+asaan,ammonium,+esi,tem+a#a,tim+al,)alsium, )lo(ia,nit(at,sulfat,<at te(o)siasi memenuhi sa(at an# te(te(a -aa a=ua estilata.

2# Pe+ba)aan

'e(o+aan ini ila)u)an a#a( mahasisa mam-u memahami an a-at mem+uat in@e)si ste(il seiaan alam +entu) sus-ensi a)ni sus-ensi hi(oo(tison asetat. us-ensi i(oo(tison asetat ste(il menu(ut Fa(ma)o-e Inonesia I aalah us-ensi ste(il hi(o)o(tison asetat alam meia ai( an# sesuai Men#anun# tia) )u(an# a(i 90> an tia) le+ih a(i 110 > )o(tison asetat 233276B a(i @umlah an# te(te(a -aa eti)et,en#an - anta(a 5,0 sam-ai !,0. umlah <at -aat an# te(a-at alam sus-ense -a(ente(al umumna +e()isa( anta(a 0,5>; 5> atau +isa mena-ai 30> alam -(e-a(at seiaan anti+ioti Lahman, 1994B.

us-ensi -a(ente(al i+uat a-a+ila o+at tia) sta+il alam +entu)  la(utan atau +ahan o+atna tia) la(ut alam -em+aa an# +iasa i#una)an a)ni ai( water for injectionB. eiaan alam +entu) sus-ensi i#una)an melalui su+ utan an int(a musula(. 'e(sa(atan an# -entin# untu) sus-ensi  -a(ente(al a)ni u)u(an -a(ti)el. )u(an -a(ti)el alam sus-ense -a(ente(al se+ai)na memili)i u)u(an an# )eil an se(a#am anta(-a(ti)elna. )u(an an# se(a#am a-at mem+e(i)an hasil isolusi an -ele-asan o+at an# e-at an a-at i-e()i(a)an. )u(an -a(ti)el an# se(a#am @u#a a-at men#u(an#i )eene(un#an a#(e#asi anta(-a(ti)el men@ai le+ih +esa( selama a)tu  -enim-ananna. A#(e#asi te(se+ut mene+a+)an tim+ulna cake  -aa sus-ense sehin##a mem+uat -e(u+ahan alam isolusi an la@u -ele-asan o+at setelah iin@e)si Lahman, 1994B.

a(at -entin# a(i sus-ense -a(ente(al an# lainna a)ni  syringeability imana aana )emuahan sus-ense iam+il en#an men##una)an s-uit in@e)si an injectability imana sus-ense -a(ente(al mem+e(i)an hasil an# +e+as -a(ti)el sehin##a tia) menim+ul)an sum+atan saat iin@e)si an saat masu) )e alam -em+uluh a(ah.

at a)tif hi(oo(tison asetat i+uat men@ai sus-ense -a(ente(al )a(ena me(u-a)an senaa an# tia) la(ut alam ai( an a-at i#una)an melalui i.m int(amusula(B atau s.. su+utanB +u)an int(a8ena. A-a+ila sus-ense an# iin@e)si)an i#una)an sea(a int(a8ena, -a(ti)el hi(oo(tison an# tia) la(ut a)an menum+at -em+uluh )a-ile( @antun# sehin##a a-at men#a)i+at)an )ematian.

eiaan i(o)o(tison asetat i#una)an untu) -en#o+atan ale(#i, se+a#ai anti (aan# an men#ham+a( -e()em+an#an sel e-ie(mis. eiaan i+uat alam 5 +uah 8ial masin#; masin# 8olumena 10mL mes)i-un alam  -em+uatanna i+uat se+ana) 60mL. -em+uatanna ile+ih)an )a(ena i)haati()an aana )ehilan#an 8olume saat -(oses -em+uatan. Dile+ih)an 8olume 10> ma)a +utuh 55mL a)an teta-i untu) memuah)an -e(hitun#an an -enim+an#an i+uatlah 8olume se+ana) 60mL.

us-ensi -a(ente(al ini men#anun# anti mi)(o+ial an -(ese(8atif  a#ent aitu +en<l al)ohol,  surface active agent   'olso(+ate;0B, viscosity agent  M NaB an tonicity agent  NalB. 'olso(+ate;0 se+a#ai AA  +e(fun#si se+a#ai <at -em+asah wetting agent B en#an a(a men#u(an#i

te#an#an -e(mu)aan / suut )onta)na. Den#an menu(un)an te#an#an  -e(mu)aan anta(a a=ua  p.i an hi(o)o(tison asetat, ma)a )eua <at te(se+ut an# semula tia) am-u( men@ai a-at am-u( )a(ena hi(o)o(tison asetat a-at te(+asahi. ean#)an M Na +e(tina) se+a#ai a#en an# menin#)at)an 8is)ositas, imana sema)in )ental suatu la(utan ma)a )ee-atan -en#ena-an sema)in )eil a)i+atna sus-ensi ma)in sta+il en#an men#au -aa hu)um to)es tentan# 8is)ositas imana )ee-atan -en#ena-an  +e(+anin# te(+ali) en#an 8is)ositas ai(an . Aana -enam+ahan M Na an -olso(+ate;0 sea(a +e(samaan a-at menin#)at)an -en#a(uh su(fa)tan an a-at mene+a+)an hilan#na muatan -e(mu)aan -a(ti)el te(is-e(si,  -enola)an te(haa- ai( te()u(an#i, an )eene(un#an le+ih )eil untu) 

men##um-al. ehin##a sus-ensi ma)in sta+il an tia) te(+entu) cake.

%en<l alohol i(o)simetil+en<enB san#at -entin# #unana alam seiaan ini aitu se+a#ai  preservative atau <at antimi)(o+a. at ini -e(lu itam+ah)an )a(ena men#in#at aah an# i#una)an untu) la(utan sus-ensi ini aalah 8ial. ial me(u-a)an suatu aah an# memun#)in)an untu)   -en##unaan +e(ulan# multiple doseB, sehin##a seiaan ini me(u-a)an seiaan

multiple dose. Multiple dose alam 8ial a-at menin##al)an lu+an# )eil -aa tutu- )a(etna setelah -en#am+ilan 8olume -e(tama en#an @a(um sunti). 7leh )a(ena itu, untu) mene#ah )ontaminasi an# +isa masu) meleati lu+an# te(se+ut seiaan ha(us i tam+ah)an en#an <at preservative.

'em+uatan sus-ensi -a(ente(al le+ih sulit i+anin# la(utan -a(ente(al te(utama masalah ste(ilisasi an -(oses -em+uatanna. %iasana +a#ian;  +a#ian a(i +ahan sus-ensi iste(ilisasi te(-isah, )emuian masin#;masin#  +ahan isus-ensi)an sea(a ase-tis. $a(ena masin#;masin# memili)i

)a(a)te(isti) seni(i ma)a tia) a-at ila)u)an ste(ilisasi a)hi(.

'aa -(a)ti)um )ali ini in@e)si ste(il i(o o(tisone asetat su-ensi i+uat se+ana) 5 8ial en#an 8olume masin#;masin# 10 ml, en#an men##una)an fo(mula :

&ia- ml men#anun# :

*/ i(o o(tisone asetat 25 m#

 Nal 9 m#

'olso(+ate 0 4 m#

M;Na 5m#

%en<il alohol 0,9 > A=ua -.i a 1 ml

Lan#)ah -e(tama an# ila)u)an aalah menim+an# semua +ahan an# i-e(lu)an. 'aa -em+uatan ste(il hi(oo(tisone asetat ini i-e(lu)an hi(oo(tisone asetat se+ana) 1,5 #(am, Nal se+ana) 0,54 #(am, 'olso(+ate 0 se+ana) 0,24 #(am, M;Na se+ana) 0,3 #(am, +en<il alohol se+ana) 0,054 #(am, an a=uaest a 60 ml.

M;Na iste(il)an alam +entu) la(utan men##una)an autola8e  -aa suhu 121°  selama 15 menit. M;Na iste(il)an alam +entu) 

la(utan )a(ena se(+u) )e(in# a(i M;Na tia) tahan -emanasan tin##i -olime( an# te(+entu) a)an (usa)B. elain itu, metoe an# i#una)an aalah metoe ste(ilisasi men##una)an autola8e, imana ua- ai( )a(ena  -emanasan autola8e a-at masu) an mem+entu) )oloi @i)a M;Na iste(ilisasi alam +entu) se(+u). La(utan M;Na i+uat en#an a(a mela(ut)an se(+u) )e(in# M;Na alam ai( -anas sam-ai semuana men#em+an#, +a(ulah itam+ah)an sisa ai(na alam )eaaan in#in. 'ela(utan i+antu en#an -en#au)an i alam mo(ti( untu) mem+antu an mem-e(e-at -(oses -ela(utan sam-ai tia) te(lihat la#i aana -a(ti)el M;Na.

ean#)an untu) hi(o o(tisone asetat, Nal, an -olso(+ate 0 iste(il)an alam o8en selama 1 @am -aa suhu 160° . te(ilisasi )e(in# ini i#una)an untu) +ahan +e(+entu) se(+u) )e(in# an# tahan -emanasan tin##i an +e(sifat hi#(os)o-is. te(ilisasi en#an a(a ini +e(tu@uan untu)  men@a#a sta+ilitas +ahan an mem+e+as)an )uman. %en<il al)ohol tia)   -e(lu iste(ilisasi )a(ena ia +e(fun#si se+a#ai antimi)(o+a, tentu sa@a suah

tia) men#anun# mi)(oo(#anisme ialamna.

etelah semua +ahan melalui ste(ilisasi ila)u)an -enam-u(an +ahan alam LAF en#an te)ni) ase-tis. 'enam-u(an seiaan ila)u)an i alam LAF a+inet untu) men#hina(i )ontaminasi )a(ena alam -em+uatanna tia) ila)u)an ste(ilisasi a)hi(. LAF  Laminary Air FlowB aalah suatu )ota) ase-ti an# ste(ilitasna ia)ini tin##i )a(ena se+elum memasu)i LAF ha(us isem-(ot alohol te(le+ih ahulu, isina(i en#an  an  -en#atu(an te)anan ua(a an# +ai) untu) mem-e()eil mi)(oo(#anisme

Dalam -enam-u(an sus-ense, i#una)an mo(ti( selain untu)  men#homo#en)an am-u(an @u#a untu) mem-e()eil u)u(an -a(ti)elna. )u(an -a(ti)el an# )eil an se(a#am men@ai -e(sa(atan -alin# -entin# alam sus-ensi. )u(an -a(ti)el an# )eil mene+a+)an sus-ensi sta+il an te(is-e(si sem-u(na alam la(utan -em+aa sehin##a memenuhi sa(at sus-ensi an# +ai). us-ensi imasu))an alam 8ial 10 mL an# telah iste(ilisasi an )emuian itutu- )ea-. ial ha(us suah iste(ilisasi te(le+ih ulu untu) men#hina(i aana )ontaminan a(i lua(. $emuian 8ial te(se+ut i+e(i eti)et +e(a(na +i(u )a(ena la(utan sus-ensi ini te(masu) o+at lua(.

$emuian ila)u)an -en#amatan sta+ilitas fisi) sus-ensi meli-uti )emam-uan -en#ena-an sta+ilitas sus-ensiB, @enis sus-ensi flo)ulasi atau eflo)ulasiB, a(na, an te(+entu) a)e atau tia). Da(i hasil -e(o+aan ia-at)an sus-ensi an# +e(a(na -utih susu. Dalam -en#amatan )eseta+ilan an te(+entu) a)e atau tia) hana ila)u)an +e+e(a-a menit setelah -em+uatan tan-a aa -e(e-atan sent(ifu#asi atau -en#a(uh suhuB seha(usna -en#amatan hal ini i la)u)an alam +e+e(a-a ha(i atau i  -e(e-at en#an -e(la)uan te(tentu tai. $a(ena a)tu an# te(+atas  -en#amatan hana ila)u)an -aa saat itu sa@a, an te(amati +aha sus-ensi sta+il an tia) mem+entu) a)e. %e(asa()an -en#amatan ia-at)an sus-ensi en#an sistem eflo)ulasi, hal ini ilihat a(i saat -en##o@o)an (in#an -a(ti)el a-at te(is-e(si )em+ali en#an muah, )ee-atan  -en#ena-an tia) te(lalu e-at an tia) te(+entu) cake.

Dila)u)an @u#a u@i ste(ilitas untu) melihat a-a)ah te(a-at mi)(o+a atau tia) -aa la(utan sus-ensi an# i+uat. Mi)(o+a itum+uh)an -aa meia a#a( untu) men#u@i ste(ilitas selama -enam-u(an an# ila)u)an i alam LAF. La(utan sus-ensi an# telah i+uat iam+il sei)it untu)  i#o(es)an -aa meia a#a(. etelah itu, meia te(se+ut iin)u+asi selama satu min##u untu) melihat aa tia)na )ontaminan mi)(o+a -aa meia a#a( te(se+ut. 'en#amatan untu) u@i ste(ilitas ila)u)an satu ha(i an satu min##u setelah sus-ense i+uat. asil -en#amatan a(i u@i ste(ilitas menun@u))an +aha tia) aa )ontaminan mi)(o+a, +ai) -aa -en#amatan satu ha(i atau-un satu min##u setelah -enum+uhan mi)(o+a -aa meia a#a(.

asil ini menun@u))an +aha -aa la(utan sus-ensi hi(oo(tisone asetat an# i+uat tia) te(a-at )ontaminan mi)(o+a an menun@u))an +aha  -(oses -em+uatan la(utan sus-ensi an# ila)u)an ste(il.

F# KESIMPULAN

1. us-ensi hi(o $o(tison Asetat +e(fun#si se+a#ai antiale(#i, anti(aan# an men#ham+at -em+elahan sel e-ie(mis

2. $om-osisi sus-ense a)ni hi(oo(tisone asetat , Nal, -olso(+ate 0, M;  Na, +en<l alohol, an a=ua -.i.

3. us-ensi i+uat sea(a ase-tis alam Laminar Air Flow LAFB a+inet.

4. us-ensi +e(a(na -utih susu, sta+il, tia) mem+entu) a)e, muah te(is-e(si alam -en##o@o)an (in#an, an tia) aa 8ial an# +oo(.

5. us-ensi an# i+uat tia) men#anun# )ontaminan mi)(o+a.

6. Da(i hasil sus-ensi an# telah i+uat ihasil)an sus-ensi en#an sistem eflo)ulasi.

G# DAFTAR PUSTAKA

Anief, Moh , 1994, Farmasetik a, "M '(ess, Go#a)a(ta

Anief, Moh,1993, Ilmu Meracik Obat Teori dan r a)ti), "M '(ess, Go#a)a(ta Anonim, 19!9, Farmakope Indonesia isi III, De-a(temen $esehatan *I, a)a(ta Anonim, 1995, Farmakope Indonesia isi I, De-a(temen $esehatan *I, a)a(ta Ansel, ., oa(, 199,  engantar !entuk "ediaan Farmasi, eisi )eem-at, I

'(ess, a)a(ta

Lahman, L., Lie+eman, .A., $ani#, .L., 1994, Teori dan raktek Farmasi Industri#  -ene(@emah iti uatmi, eisi )e;3, I '(ess, a)a(ta

oi#t,*uolf, 194,  !uku elajaran Teknologi Farmasi#ite(@emah)n oleh (.oenani Noe(ono, eisi )e;5, "a@ah Maa ni8e(sit '(ess, Go#a)a(ta

Men#etahui Go#a)a(ta, 10 Mei 2016

Asisten )o(e)si '(a)ti)an

H# JA;ABAN PERTANYAAN

# Je&a.an '$%$an 1en--$naan 1o&5orba'e 60<

'olso(+ate 0 aalah salah satu @enis surface active agent  an# i#una)an alam sus-ensi -a(ente(al. 'olso(+ate 0 +e)e(@a en#an menu(un)an te#an#an

anta(mu)a anta(a a=ua p.i an hi(oo(tisone asetat sehin##a )eua <at te(se+ut an# semula tia) am-u( a-at men@ai am-u( )a(ena hi(oo(tisone asetat a-at te(+asahi. 'en##unaan surface active agent  +e(sama en#an suatu

hi(o)oloi -olso(+ate 0 +e(sama M;NaB a-at menam+ah -en#a(uh su(fa)tan an mene+a+)an hilan#na muatan -aa -e(mu)aan a(i -a(ti)el te(is-e(si hi(o o(tisone asetatB, -enola)an ai(, an +e()u(an#na

)eene(un#an untu) men##um-al, sehin##a sus-ensi an# ihasil)an men@ai le+ih sta+il.

2# A1a 9$n-, ben85& a&co)o& (a&a+ 9or+$&a 'ereb$'< Je&a.an=

'en##unaan +en<l alohol alam fo(mulasi ste(il hi(o o(tisone asetat sus-ensi ini +e(tu@uan se+a#ai anti+a)te(i/ antimi)(o+a  preservatif B, )a(ena aah an# i#una)an aalah 8ial. ial me(u-a)an aah an# memun#)in)an -en##unaan  +e(ulan# multiple$doseB sehin##a untu) mene#ah )ontaminasi a(i lin#)un#an

lua( a)i+at -en##unaan +e(ulan# -e(lu itam+ah)an a#en -(ese(8atif. ># Je&a.an +en-a1a "M"*Na (,'er,&.an (a&a+ ben'$. &ar$'an<

M;Na iste(il)an alam +entu) la(utan )a(ena se(+u) )e(in# M;Na tia) tahan -emanasan, selain itu ua- ai( a(i -emanasan -aa autola8e a-at

mem+asahi se(+u) M;Na sehin##a te(+entu) )oloi.

?# Se(,aan ,n%e., cor',one ae'a' (,ber,.an +e&a&$, r$'e a1a< Men-a1a< eiaan ste(il hi(o o(tisone asetat sus-ensi a-at i#una)an sea(a

int(amusula( an su+)utan. In@e)si sus-ensi ini tia) +isa i#una)an sea(a int(a8ena )a(ena men#anun# -a(ti)el tia) la(ut an# a-at menum+at  -em+uluh a(ah.

Generation 2012 universal ovens are available October 2012.

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components, hardening plastic resin or heating plasticine. Our U universal oven stands for unparalleled precise, even and gentle temperature control.

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)ue to the almost unlimited programming of temperature control profiles, the 6emmert humidity chamer >" provides the ideal environments for the chamer load.

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*n the 4uality la of a worldwide renowned automotive supplier  cales and wires undergo a strict ageing test in the heating oven.

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Before numerous material tests are performed in the Ccement2ound uilding materialsD team of the 5erman B-6, the samples are conditioned in a cooled incuator *, a drying oven and a "T" climatic test chamer from 6emmert.