SEKOLAH TINGGI FARMASI INDONESIA SEKOLAH TINGGI FARMASI INDONESIA LABORATORIUM TEKNOLOGI FARMASI LABORATORIUM TEKNOLOGI FARMASI JURNAL PRAKTIKUM TEKNOLOGI FORMULASI SEDIAAN SOLIDA JURNAL PRAKTIKUM TEKNOLOGI FORMULASI SEDIAAN SOLIDA SEMESTER IV โ 2016 SEMESTER IV โ 2016 ย Nama
ย Nama : Riri๎ Ri!a๎a: Riri๎ Ri!a๎a ย NMP
ย NMP : A : A 1"1 12#1"1 12# $
$aa% % AA&&%%ii'' : : AA(((())**++rrii๎๎))(( JJ++mm((aa, , %%aa--((..%% : : //00๎๎00000 0 TTaa--((..%% D
D)๎)๎i๎ i๎ ๎a๎a๎ a๎ a(a(a๎a๎a๎ *๎ *.m.mi(i(i,i,a๎ a๎ ๎๎)๎)๎i๎i๎ : 3: 300 00 m4m4
: Kar.๎a ๎.๎4a๎ ๎)๎i๎ 300 m4 *+๎ ๎a*a% : Kar.๎a ๎.๎4a๎ ๎)๎i๎ 300 m4 *+๎ ๎a*a% m.m
m.m-.ri-.ri&a๎ &a๎ .'.& .'.& m.๎m.๎+r++r+๎&a๎&a๎ ๎ &a๎&a๎ar ar a๎ama๎am +ra% ๎a(am ๎ara,๎
+ra% ๎a(am ๎ara,๎ M
M..%%))๎๎. . **..mm--++aa%%aa๎๎ : : GGrraa๎๎++((aa๎๎i i --aa๎๎aa,, II๎๎ PPRREEFFOORRMMUULLAASSII
I๎
I๎11 NaNama ma $$a% a% AA&%&%i'i' : A: A(((())*+*+riri๎)๎)(( S%r+&%+r
S%r+&%+r
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B..rraa% % mm))((..&&++(( : : 113366551111 P.m.ri
P.m.ria๎ a๎ : : S.r-+S.r-+& & ,a(+๎5 ,a(+๎5 *+%i, *+%i, ,i๎44,i๎44a a ,am*,am*ir ir *+%i,*+%i,๎ ๎ -.r-a+-.r-a+ (.ma,๎
(.ma,๎ K.(
K.(ar+ar+%a๎ %a๎ : : Sa๎Sa๎4a% 4a% ๎+&๎+&ar ar (ar+(ar+% % ๎a(๎a(am am air air ๎a๎ ๎a๎ .%a.%a๎)(๎)(๎ ๎ (ar+(ar+%% ๎a(
๎a(am am (ar+(ar+%a๎ &a%a๎ &a(i+(i+m ๎a๎ ๎am ๎a๎ ๎a%ri%ri+m ,i๎+m ,i๎r)&r)&๎i๎๎i๎a๎a๎ ย *ra&%i๎ %i๎a& (ar+% ๎a(am &()r)')rm ๎a๎ .%.r๎
ย *ra&%i๎ %i๎a& (ar+% ๎a(am &()r)')rm ๎a๎ .%.r๎ Ti%i&
Ti%i& (.(., (.(., :3/078:3/078 ย *H
P.๎44+a๎aa๎ %.ra*i: Pr)'i(a&๎i๎ 4)+% ๎a๎ -a%+ a๎am +ra% ๎a๎ &a(๎i+m )&๎a(a% ๎i 4i๎9a(๎
OTT : %.r,a๎a* -a,a๎ *.๎4)&๎i๎a๎i๎ (Farmakope Indonesia ed V. 2014)
I๎2 ASPEK FARMAKOLOGI
A-๎)r-๎i Ora( : A()*+ri๎)( ,am*ir ๎ 0; ๎ia-๎)r*๎i ๎.%.(a, ย *.m-.ria๎ *.r)ra(๎
Bi)%ra๎๎')rma๎i : M.&a๎i๎m. < ๎ = %i๎๎a&a๎ %i๎a& ๎i&.%a,+i ๎.๎4a๎ ย *a๎%i ๎ m+๎>+( -r)๎&)๎i(a%a๎i !a๎4 ๎im.๎ia๎i )(., ย *.๎4,am-a%a๎ &)m*.%i%i' ๎ari 2 i๎)?im ๎ari ย *,)๎*,)๎i.๎%.ra๎. < PDE III ๎a๎ 5 *a๎a %i๎4&a% (.-i, r.๎๎a, 5 PDE IV = 5 ๎.๎a๎4&a๎ ๎)๎ @ -r)๎&)๎i(a%)rย %i๎๎a&a๎ *r)'i(a&๎i๎ m+๎4&i๎ ๎im.๎ia๎i m.(a(+i m.&a๎i๎m. m)(.&+(.r !a๎4 %i๎a& m.(i-a%&a๎ ย *.๎4,am-a%a๎ PDE III a%a+ a๎%a4)๎i๎m. r.๎.*%)rย
a๎.๎)๎i๎๎ ๎a&%+ Par+, : 1 โ 3 9am
Di๎%ri-+๎i : V)(+m. ๎i๎%ri-+๎i๎!a 156 L๎K4๎
M.%a-)(i๎m. :A(+*+ri๎)( ๎im.%a-)(i๎m. ๎.๎๎iri )(., Ca๎%i๎ )&๎i๎a๎. m.๎9a๎i m.%a-)(i% a&%i' )C!*+ri๎)( < #/;=๎ E(imi๎a๎i : E&๎&r.๎i a()*+ri๎)( ๎a(am +ri๎ ๎.-.๎ar #6; ๎a(am
ย -.๎%+& )C!*+ri๎)( ๎a๎ 12; ๎a(am -.๎%+& +%+,๎
D)๎i๎ : 100 m4๎
M.&a๎i๎m. &.r9a : A()*+ri๎)( a๎a(a, )-a% *.๎!a&i% *irai <4)+%= !a๎4 ๎a*a% m.๎+r+๎&a๎ &a๎ar a๎am +ra% ๎a(am ๎ara,๎ A()*+ri๎)( -.&.r9a ๎.๎4a๎ m.๎4,am-a% Ca๎%i๎ )&๎i๎a๎. !ai%+ .๎?im !a๎4 ๎a*a% m.๎4+-a, ,i*)Ca๎%i๎ m.๎9a๎i Ca๎%i๎5 ๎.(a๎9+%๎!a m.๎4+-a, Ca๎%i๎ m.๎9a๎i a๎am +ra%๎ Da(am %+-+, A()*+ri๎)( m.๎4a(ami m.%a-)(i๎m. m.๎9a๎i )&๎i*+ri๎)( <a()?a๎%i๎= !a๎4 9+4a -.&.r9a ๎.-a4ai *.๎4,am-a% .๎?im Ca๎%i๎ )&๎i๎a๎.๎ M.&a๎i๎m. &.r9a ๎.๎!a๎a i๎i -.r๎a๎ar&a๎ &a%a-)(i๎m. *+ri๎ ๎a๎ m.๎4+ra๎4i ย *r)๎+&๎i a๎am +ra%5 %a๎*a m.๎44a๎44+ -i)๎i๎%.๎a ย *+ri๎๎
E'.& ๎am*i๎4 :R+am <,.๎%i&a๎ %.ra*i๎ 9i&a r+am ri๎4a๎5 4+๎a&a๎ &.m-a(i ๎.๎4a๎ ,a%i@,a%i ๎am+๎ ,.๎%i&a๎ ๎.4.ra a*a-i(a m+๎>+( &.m-a(i r.a&๎i &+(i% ๎i&ai%&a๎ ๎.๎4a๎ *.๎4.(+*a๎a๎ &+(i%5 ๎.mam5 (im'a๎.๎)*a%i5 ar%ra(4ia5 ๎a๎ .)๎i๎)'i(ia5 ๎i๎๎r)m miri* ๎i๎๎r)m S%.๎.๎๎@J),๎๎)๎ a%a+ L!.((5 9ara๎4 %.r9a๎i=๎ 4a๎44+a๎ ๎a(+ra๎ >.r๎a๎ 9ara๎4 ma(ai๎.๎ ๎a&i% &.*a(a5 ๎.r%i4)5 m.๎4a๎%+&5 4a๎44+a๎ *.๎4.>a*a๎5 ,i*.r%.๎๎i5 ๎.*)๎i% Ca๎%i๎ ๎i )%)% %a๎*a 4.9a(a5 a()*.๎ia5 ,.*a%)%)&๎i๎i%a๎5 *ara@.๎%a๎ia5 ๎a๎ ๎.+r)*a%i๎
(Iso Farmakoterapi 1) I๎3 $a% Tam-a,a๎
Sorbitol R+m+๎ &imia : 86H1"O6
P.m.ria๎ :๎.r-+&๎ 4ra๎+( a%a+ (.m*.๎4a๎๎ ,i4r)๎&)*i๎๎ *+%i,๎ ma๎i๎๎
K.4+๎aa๎ ๎a(am ')rm+(a : Ba,a๎ *.๎4i๎i
A(a๎a๎ *.๎am-a,a๎ ?a% %am-a,a๎ ๎a(am ')rm+(a
K.(ar+%a๎ : ๎a๎๎4a% m+๎a, (ar+% ๎a(am air๎ ๎+&ar (ar+% ๎a(am .%a๎)(5 ๎a(am m.%,a๎)( ๎a๎ ๎a(am a๎am a๎.%a%๎
ย *H : 35/ @ #
D.๎๎i%a๎ : 1๎"๎ 4๎>m3
A(ira๎ : Kara&%.ri๎%i& a(ira๎ -.r๎aria๎i %.r4a๎%+๎4 *a๎a ย *ar%i&.( +&+ra๎ ๎a๎ &.(a๎ ๎)r-i%)( ๎i4+๎a&a๎ ๎ Ni(ai ย -+-+& ,a(+๎ >.๎๎.r+๎4 -+r+& m.๎4a(ir 5 ๎.m.๎%ara
๎i(ai 4ra๎+(ar m.mi(i&i a(ira๎ -ai& %.*a%@i&a%a๎ ๎ K.(.m-a-a๎ : @
S%a-i(i%a๎ : S)r-i%)( a๎a(a, &imia r.(a%i' i๎.r% ๎a๎ &)m*a%i-.( ๎.๎4a๎ ๎.-a4ia๎ -.๎ar .&๎i*i.๎ ๎ Ha( i๎i ๎%a-i( ๎i +๎ara ๎.๎4a๎ %i๎a& a๎a๎!a &a%a(i๎ ๎a๎ ๎i๎4i๎5 .๎>.rย a๎am ๎a๎ -a๎a ๎ S)r-i%)( %i๎a& 4.(a* a%a+ %.r+rai ๎i ๎+,+ !a๎4 %i๎44i a%a+ ๎i ,a๎a*a๎ ami๎a ๎ i๎i ๎)๎'(amma-(. 5 ๎)๎>)rr)๎i๎. 5 ๎a๎ ๎)๎๎)(a%i(. ๎ M.๎&i*+๎ ๎)r-i%)( %a,a๎ %.r,a๎a* '.rm.๎%a๎i )(., ย -a๎!a& mi&r))r4a๎i๎m. 5 *.๎4a๎.% ,ar+๎ ๎i%am-a,&a๎ &. ๎)(+๎i ๎)r-i%)( ๎S)(+๎i ๎a*a%
๎i๎im*a๎ ๎a(am &a>a 5 *(a๎%i& 5 a(+mi๎i+m 5 ๎a๎ ๎%ai๎(.๎๎ &)๎%ai๎.r -a9a ๎ S)(+๎i +๎%+& i๎9.&๎i ๎a*a% ๎i๎%.ri(&a๎ ๎.๎4a๎ a+%)&(a' ๎Ba,a๎ ma๎๎a( a๎a(a, ,i4r)๎&)*i๎ ๎a๎ ,ar+๎ ๎i๎im*a๎ ๎a(am ๎a๎a, &.๎a* +๎ara ๎i %.m*a% !a๎4 ๎.9+& ๎a๎ &.ri๎4 ๎
(Farmakope Indonesia ed V.2014, Handbook Of Pharmace๎tica!ย ย "#cipients ed $.200%)
Gelatin
R+m+๎ &imia : 8#6H12"O2๎ย N2"
P.m.ria๎ : L.m-ara๎5 &.*i๎4a๎ a%a+ *)%)๎4a๎5 a%a+ ๎.r-+&ย &a๎ar ๎am*ai ,a(+๎๎ &+๎i๎4 (.ma, a%a+ >)&(a% %.ra๎4๎ ๎ar๎a -.r๎aria๎i %.r4a๎%+๎4 +&+ra๎ *ar%i&.(๎ Lar+%a๎๎!a -.r-a+ (.ma, ๎.*.r%i &a(๎+๎ Ji&a &.ri๎4 ๎a%-i( ๎i +๎ara5 %.%a*i m+๎a, %.r+rai )(., mi&r)-a ย 9i&a (.m-a- a%a+ ๎a(am -.๎%+& (ar+%a๎๎ G.(a%i๎ %i*. A m.๎+๎9+&&a๎ %i%i& i๎).(.&%ri& a๎%ara *H # ๎a๎ *H ๎5 4.(a%i๎ %i*. B m.๎+๎9+&&a๎ %i%i& i๎).(.&%ri&ย a๎%ara *H "5# ๎a๎ *H /52๎
K.4+๎aa๎ ๎a(am ')rm+(a : P.๎4i&a%
A(a๎a๎ *.๎am-a,a๎ ?a% %am-a,a๎ ๎a(am ')rm+(a: %i๎a& m.mi(i&i ๎i'a% ๎.-a4ai -a,a๎ *.๎4)&๎i๎a๎i๎
K.(ar+%a๎ : %i๎a& (ar+% ๎a(am air ๎i๎4i๎๎ m.๎4.m-a๎4 ๎a๎ (+๎a& -i(a ๎i>.(+* ๎a(am air๎ m.๎!.ra* air ๎.>ara ย -.r%a,a* ๎.-a๎!a& / โ 10 &a(i -.ra%๎!a๎ (ar+% ๎a(am air *a๎a๎5 ๎a(am a๎am a๎.%a% 6 N ๎a๎ ๎a(am >am*+ra๎ *a๎a๎ 4(i๎.ri๎ ๎a๎ ๎a(am air๎ %i๎a& (ar+% ๎a(am .%a๎)(5 ๎a(am &()r)')rm5 ๎a(am .%.r5 ๎a(am mi๎!a& (.ma& ๎a๎ ๎a(am mi๎!a& m.๎4+a*๎
ย *H : #@๎
D.๎๎i%a๎ : 1๎32 4๎>m3
A(ira๎ : @
K.(.m-a-a๎ : @
S%a-i(i%a๎ : G.(a%i๎ &.ri๎4 ๎%a-i( ๎i +๎ara ๎ S)(+๎i 4.(a%i๎ -.rairย ย 9+4a ๎%a-i( +๎%+& ๎a&%+ !a๎4 (ama 9i&a ๎i๎im*a๎
๎a(am &)๎๎i๎i ๎i๎4i๎ %a*i m.r.&a %+๎๎+& ๎.4ra๎a๎i ย -a&%.ri ๎ Pa๎a ๎+,+ ๎i a%a๎ /0๎ 78 5 ๎)(+๎i 4.(a%i๎ ย -.rair ๎a*a% m.๎4a(ami ๎.*)(im.ri๎a๎i (am-a% ๎a๎
ย *.๎+r+๎a๎ &.&+a%a๎ 4.( ๎a*a% %.r9a๎i *a๎a +(a๎4 ๎ D.*)(!m.ri?a@%i)๎ m.๎9a๎i (.-i, >.*a% *a๎a ๎+,+ ๎i a%a๎ 6/๎ 78 5 ๎a๎ 4.( K.&+a%a๎ ๎a*a% ๎i&+ra๎4i ๎.%.๎4a,๎!a &.%i&a ๎)(+๎i ๎i*a๎a๎&a๎ *a๎a ๎ 0๎ 78 ๎.(ama 1 9am ๎ Ti๎4&a% ๎a๎ (+a๎๎!a ๎.*)(im.ri๎a๎i %.r4a๎%+๎4 *a๎a -.ra% m)(.&+( 4.(a%i๎ 5 ๎.๎4a๎ r.๎๎a, -.ra% m)(.&+( -a,a๎ m.m-+๎+& (.-i, >.*a% ๎ (Farmakope Indonesia ed V.2014, Handbook Of Pharmace๎tica!ย
ย "#cipients ed $.200%) Metil Selulosa
P.m.ria๎ : ๎.r-+& -.r๎.ra% a%a+ 4ra๎+(5 -.r๎ar๎a *+%i,๎ S+๎*.๎๎. ๎a(am air -.r.a&๎i ๎.%ra( %.r,a๎a* (a&m+๎ P๎ m.๎4.m-a๎4 ๎a(am air ๎a๎ m.m-.๎%+& ๎+๎*.๎๎. !a๎4 9.r๎i, ,i๎44a )*a(.๎.๎5 &.๎%a(5 &)()i๎a(๎
K.4+๎aa๎ ๎a(am ')rm+(a : D.๎i๎%.4ra๎
A(a๎a๎ *.๎am-a,a๎ ?a% %am-a,a๎ ๎a(am ')rm+(a: &ar.๎a %i๎a& m.mi(i&i ๎i'a% ๎.-a4ai -a,a๎ *.๎4)&๎i๎a๎i๎
K.(ar+%a๎ : %i๎a& (ar+% ๎a(am .%a๎)(5 ๎a(am .%.r ๎a๎ ๎a(am &()r)')rm๎ (ar+% ๎a(am a๎am a๎.%a% 4(a>ia( ๎a๎ ๎a(am >am*+ra๎ ๎)(+m. ๎ama .%a๎)( ๎a๎ ๎a(am &()r)')rm๎
ย *H : /@๎
D.๎๎i%a๎ :1๎3"1 4๎>m3
(Farmakope Indonesia ed V.2014, Handbook Of Pharmace๎tica!ย ย "#cipients ed $.200%)
Kalsium Stearat R+m+๎ &imia : 836H#08aO"
P.m.ria๎ : P+%i, &.&+๎i๎4a๎ @ *+%i, 5 -+-+& -.๎ar m.mi(i&i ย -a+ !a๎4 &,a๎ ๎.๎i&i% ๎B.-a๎ ๎ari -+%ira๎ ๎
K.4+๎aa๎ ๎a(am ')rm+(a : L+-ri&a๎
A(a๎a๎ *.๎am-a,a๎ ?a% %am-a,a๎ ๎a(am ')rm+(a: &ar.๎a %i๎a& m.mi(i&i ๎i'a% ๎.-a4ai -a,a๎ *.๎4)&๎i๎a๎
K.(ar+%a๎ : Pra&%i๎ %i๎a& (ar+% a%a+ %i๎a& (ar+% ๎a(am .%a๎)( <๎/; = 5.%.r 5 &()r)')rm 5 a๎.%)๎ 5 ๎a๎ air ๎ S.๎i&i% (ar+% ๎a(am air *a๎a๎ a(&),)( 5 ๎a๎ ๎a!+ra๎ *a๎a๎ ๎a๎ mi๎.ra( mi๎!a& ๎ Lar+% ๎a(am air *a๎a๎ *iri๎i๎๎
ย *H : @
D.๎๎i%a๎ :1๎06" โ 1๎0๎6 4๎>m3
K.(.m-a-a๎ : @
S%a-i(i%a๎ : Ka(๎i+m ๎%.ara% ๎%a-i( ๎a๎ ,ar+๎ ๎i๎im*a๎ ๎i ๎.-+a, ๎a๎a, %.r%+%+* ๎i %.m*a% !a๎4 ๎.9+& ๎a๎ &.ri๎4 ๎
(Farmakope Indonesia ed V.2014, Handbook Of Pharmace๎tica!ย ย "#cipients ed $.200%)
Zinc Stearate R+m+๎ &imia : 836H#0O"$๎
P.m.ria๎ :*+%i,5 r+a,5 -+-+& ,i๎r)')-i&5 -.-a๎ ๎ari -+%ira๎ ๎a๎ ๎.๎4a๎ -a+ !a๎4 &,a๎๎
K.4+๎aa๎ ๎a(am ')rm+(a : G(i๎a๎
A(a๎a๎ *.๎am-a,a๎ ?a% %am-a,a๎ ๎a(am ')rm+(a: &ar.๎a %i๎a&ย m.mi(i&i ๎i'a% ๎.-a4ai -a,a๎ *.๎4)&๎i๎a๎i๎
K.(ar+%a๎ : *ra&%i๎ %i๎a& (ar+% ๎a(am .%a๎)(5 .%.r5 air5 ๎a๎ ย *.(ar+% )&๎i4.๎5 (ar+% ๎a(am a๎am5 -.๎?.๎.5 ๎a๎ ย *.(ar+% ar)ma%i> (ai๎๎!a๎
D.๎๎i%a๎ : 1๎0๎ 4๎>m3
A(ira๎ :@
S%a-i(i%a๎ : ?i๎> ๎%.ara%. ๎%a-i( ๎a๎ ,ar+๎ ๎i๎im*a๎ ๎a(am ๎a๎a, %.r%+%+* -ai& ๎i %.m*a% !a๎4 ๎.9+& ๎a๎ &.ri๎4๎
(Handbook Of Pharmace๎tica! "#cipients ed $.200%)
II๎ FORMULASI ๎ TEKNIK PEMBUATAN
a๎ F)rm+(a !a๎4 a&a๎ ๎i-+a% R๎ A(()*+ri๎)( 100 m4 S)r-i%)( 1๎ 56; G.(a%i๎ "; Air ๎๎๎ M.%i( ๎.(+()๎a 3; Ka(๎i+m ๎%.ara% 1; $i๎> ๎%.ara% 2;
A(()*+ri๎)( : $a% a&%i'
S)r-i%)( : Ba,a๎ *.๎4i๎i G.(a%i๎ : P.๎4i&a% M.%i( ๎.(+()๎a : D.๎i๎%.4ra๎ Ka(๎i+m ๎%.ara% : L+-ri&a๎ $i๎> ๎%.ara% : G(i๎a๎
ย -๎ M.%)๎a !a๎4 ๎i4+๎a&a๎ : Gra๎+(a๎i -a๎a,๎
>๎ A(a๎a๎ *.mi(i,a๎ m.%)๎. : Kar.๎a ?a% a&%i' m.mi(i&i %i%i& (.(., !a๎4 >+&+* %i๎44i ๎.,i๎44a ๎a*a% ๎i(a&+&a๎ ย *.ma๎a๎a๎๎
A(()*+ri๎)( 100m4 : Kar.๎a ๎.๎4a๎ ๎)๎i๎ 100 m4 *+๎ ๎a*a% m.m-.ri&a๎ .'.& m.๎+r+๎&a๎ &a๎ar a๎am +ra% ๎a(am ๎ara,๎
S)r-i%)( 1๎ 56 ; : S.๎+ai ๎.๎4a๎ r.๎%a๎4 &a๎ar !a๎4 ๎i%.๎%+&a๎ 10 ;@๎0 ;
G.(a%i๎ "; : S.๎+ai ๎.๎4a๎ r.๎%a๎4 &a๎ar !a๎4 ๎i%.๎%+&a๎ 2 โ 10;
M.%i( ๎.(+()๎a 3; : S.๎+ai ๎.๎4a๎ r.๎%a๎4 &a๎ar !a๎ ๎i%.๎%+&a๎ 05/ โ /;
Ka(๎i+m ๎%.ara% 1; : S.๎+ai ๎.๎4a๎ r.๎%a๎4 &a๎ar !a๎4 ๎i%.๎%+&a๎ 052/ โ 2;
$i๎> ๎%.ara% 2; : S.๎+ai ๎.๎4a๎ r.๎%a๎4 &a๎ar !a๎4 ๎i%.๎%+&a๎ 1 @ 3;
(Handbook Of Pharmace๎tica! "#cipients ed $.200%)
III๎ PERHITUNGAN
a๎ S.%ia* %a-(.% m.๎4a๎๎+๎4 : 300 m4 A(()*+ri๎)(
ย -๎ B)-)% %a-(.% : 3/0 m4
>๎ J+m(a, %a-(.% : /0๎000 %a-(.% ๎ 10 ; ๎ //000 %a-(.% III๎1 U๎%+& Tia* Ta-(.%
1๎ Fa๎a ๎a(am A(()*+ri๎)( 053 4 C //000 4 ๎ 16๎/00 4 S)r-i%)( 1๎ 56; C 053/0 4 ๎ 0506/1 4 C //000 ๎ 3๎/๎ 0 4 G.(a%i๎ "; C 053/0 4 ๎ 0๎01" 4 C //000 ๎ ##0 4 Air ๎๎๎ 2๎ Fa๎a (+ar
M.%i( ๎.(+()๎a 3; C -)-)% 4ra๎+( Ka(๎i+m ๎%.ara% 1; C -)-)% 4ra๎+( $i๎> ๎%.ara% 2; C -)-)% 4ra๎+(
3๎2๎B)-)% 4ra๎+( %.)ri%i๎: 16๎/00 4 ๎ 3๎/๎ 0 4 ๎ ##0 4 ๎ #๎050๎ 4 III๎2 P.๎im-a๎4a๎ A(()*+ri๎)( 16๎/00 4ram S)r-i%)( 3๎/๎ 0 4ram G.(a%i๎ ##0 4ram Air ๎๎๎
M.%i( ๎.(+()๎a ๎ 4ram
Ka(๎i+m ๎%.ara% ๎ 4ram
$i๎> ๎%.ara% ๎ 4ram
Di%im-a๎4 ?a%@?a% !a๎4 a&a๎ ๎i*a&ai *a๎a 'a๎. ๎a(am5 ๎.๎+ai ๎.๎4a๎ -)-)% *.๎im-a๎4a๎ ma๎i๎4@ma๎i๎4 ?a%๎ K.m+๎ia๎ ๎i>am*+r&a๎ ๎a%+ *.r ๎a%+ ๎.>ara ,)m)4.๎5 &.>+a(i 4.(a%i๎5 ๎i (ar+%&a๎ %.r(.-i, ๎a,+(+ ๎.๎4a๎ m.๎44+๎a&a๎ air ๎am*ai (ar+%๎ K.m+๎ia๎ ๎i๎.m*r)%&a๎ *a๎a ๎am*+ra๎ ?a%5 ๎am-i( ๎.๎.&a(i ๎i a๎+&๎ S.%.(a, ma๎๎a ๎.r-+& -a๎a, ,i๎44a ๎a*a% ๎i &.*a(5 &.m+๎ia๎ ๎ia!a& ๎.๎4a๎ m.๎44+๎a&a๎ m.๎, 12๎ K.m+๎ia๎ ๎i&.ri๎4&a๎๎ S.%.(a, &.ri๎45 ๎i >.& &a๎ar air๎ K.m+๎ia๎ ๎ia!a&ย &.m-a(i ๎.๎4a๎ m.๎44+๎a&a๎ m.๎, 2"๎325 (a(+ m.๎44+๎a&a๎ m.๎, "0๎ Gra๎+( !a๎4 ๎i*a&ai a๎a(a, 4ra๎+( !a๎4 %.r%a,a๎ *a๎a m.๎, "0๎ Ji&a ย -a๎!a&๎!a !a๎4 ()()๎ *a๎a ๎aa% *.๎4a!a&a๎ ๎.๎4a๎ m.๎, "05 ma&a !a๎4 ()()๎ %.r๎.-+% ๎i-a๎a,i &.m-a(i5 ๎i&.ri๎4&a๎ ๎a๎ ๎ia!a& ๎am*ai ๎i๎a*a%&a๎ 4ra๎+( !a๎4 ๎ama %.r%a,a๎ *a๎a m.๎, "0๎ &.m+๎ia๎ 4ra๎+( ๎i.๎a(+a๎i ๎a๎ ๎i>am*+r&a๎ ๎.๎4a๎ 'a๎. (+ar๎ La(+ ๎i>.%a&๎ S.%.(a, 9a๎i %a-(.%5 ๎i(a&+&a๎ .๎a(+a๎i %a-(.%๎
V๎ EVALUASI ๎ANG DILAKUKAN
V๎1 Gra๎+(
1๎ P.๎.%a*a๎ &a๎ar airย
2๎ P.๎.%a*a๎ -)-)% 9.๎i๎ ๎!a%a5 -)-)% 9.๎i๎ mam*a%5 &a๎arย &.mam*a%a๎5 ๎a๎ *)r)๎i%a๎๎
3๎ K.>.*a%a๎ a(ir๎ "๎ S+๎+% i๎%ira,a%๎ V๎2 Ta-(.% 1๎ P.๎am*i(a๎ 2๎ K.๎.ra4ama๎ +&+ra๎ 3๎ K.๎.ra4ama๎ -)-)% "๎ K.&.ra๎a๎ %a-(.% /๎ Fria-i(i%a๎ 6๎ Fri&๎i-i(i%a๎ #๎ U9i ๎a&%+ ,a๎>+r VI๎ KEMASAN ๎ LABEL
Kemasan
8 P.๎!im*a๎a๎ : ๎i๎im*a๎ ๎i%.m*a% !a๎4 ๎.9+& ๎a๎ &.ri๎4 ๎.r%a %.r,i๎๎ar ๎ari ๎i๎ar ma%a,ari๎
U๎%+& &.%.ra๎4a๎ (.-i, (a๎9+% (i,a% ๎i-r)๎+rย ย N) R.4 : DKL//00011A1 ย NO๎Ba%,: 0/1D101 T4๎*r)๎+&๎i : M.i ALLUNOL Ta-(.% PT : Ara๎ia๎๎a Farma Ba๎๎+๎4 I๎๎)๎.๎ia I๎i : 300 %a-(.% ALLUNOL Ta-(.% PT : Ara๎ia๎๎a Farma Ba๎๎+๎4 I๎๎)๎.๎ia I๎i : 300 %a-(.% Tia* %a-(.% m.๎4a๎๎+๎4 A(()*+ri๎)( 300 m4 D)๎i๎ : Li,a% ๎i-r)๎+. I๎๎i&a๎i : Li,a% ๎i-r)๎+rย
Logo Label
TABLET
Alunol 100mg
PT.ANIM PHARMA Bandung-Indones๎a Is๎ 100!a"le! Komposisi :Tiap tablet mengandung ย Allopurinoal...100mg Dosis : lihat di brosur. Indikasi : Lihat di brosurย F#31:61F1321 Penyimpanan:
#๎m$and๎ !em$a! %angse&u'dan 'e(๎ng) !e(l๎ndungda(๎ *a+a%a.
No. Reg, No. Ba!*+, ย Tgl. P(odu's๎ ,Me๎ 2015 ๎๎$. da!e,Me๎ 2017 /๎$(odu's๎ ole+, /๎๎1500100110A1 05150101
K
ย ALUNOL
P.๎9.(a๎a๎ !a๎4 %.r๎a*a% *a๎a &.ma๎a๎ ๎a๎ -r)๎+r *r)๎+& ย Nama ๎a4a๎4 : ALUNOL
ย N)๎R.4i๎%ra๎i : DKL 1/00100110A1 ย N)๎-a%>, : 0/1D101
Ta๎44a( *r)๎+&๎i : M.i 201/
Brosur
ALUNOL
Komposisi :
Tia* %a-(.% m.๎4a๎๎+๎4 : A((+*+ri๎)( 300 m4
Mekanisme Kerja :
A()*+ri๎)( a๎a(a, )-a% *.๎!a&i% *irai <4)+%= !a๎4 ๎a*a% m.๎+r+๎&a๎ &a๎ar a๎am +ra% ๎a(am ๎ara,๎ A()*+ri๎)( -.&.r9a ๎.๎4a๎ m.๎4,am-a% Ca๎%i๎ )&๎i๎a๎. !ai%+ .๎?im !a๎4 ๎a*a% m.๎4+-a, ,i*)Ca๎%i๎ m.๎9a๎i Ca๎%i๎5 ๎.(a๎9+%๎!a m.๎4+-a, Ca๎%i๎ m.๎9a๎i a๎am +ra%๎
Dosis : Dewasa:
D)๎i๎ a๎a( 300 m4 ๎.,ari๎
D)๎i๎ ma&๎ima( !a๎4 ๎ia๎9+r&a๎ ๎ 00 m4 ๎.,ari๎ Pa๎i.๎ ๎.๎4a๎ 4a๎44+a๎ 4i๎9a( 100 @ 200 m4 ๎.,ari๎ Anak 6 - ๎! ta"un:
Bi(a ๎i๎.r%ai *.๎!a&i% &a๎&.r5 ๎)๎i๎ ma&๎ima( 300 m4 ๎.,ari๎ Anak #i bawa" 6 ta"un:
D)๎i๎ ma&๎ima( 1/0 m4 ๎.,ari๎
$n#ikasi :
G)+% ๎a๎ ,i*.r+ri๎.mia๎
Kontra $n#ikasi :
A(.r4i %.r,a๎a* A(+*+ri๎)(๎ P.๎๎.ri%a ๎.๎4a๎ *.๎!a&i% ,a%i ๎a๎ ๎-)๎. marr)๎ ๎+**r.๎๎i)๎๎
%&ek Samping :
R.a&๎i ,i*.r๎.๎๎i%i๎i%a๎5 r+am ma&+()*a*+(ar ๎i๎a,+(+i *r+ri%+๎5 +r%i&aria5 .&๎')(ia%i' ๎a๎ (.๎i *+r*+ra5 ๎.rma%i%i๎5 ๎.'ri%i๎5 'a๎&+(i%i๎ ๎a๎ ๎i๎๎r)m. *)(iar%ri%i๎๎ D.mam5 .)๎i๎)'i(ia5 &.4a4a(a๎ ,a%i ๎a๎ 4i๎9a(5 m+a(5 m+๎%a,5 ๎iar.5 ra๎a m.๎4a๎%+&5 ๎a&i% &.*a(a ๎a๎ ra๎a ()4am๎
$nteraksi 'bat :
P.m-.ria๎ A()*+ri๎)( -.r๎ama ๎.๎4a๎ a?a%i)*ri๎5 m.r&a*%)*+ri๎ a%a+ ๎i&()%)๎'ami๎5 ๎a*a% m.๎i๎4&a%&a๎ .'.& %)&๎i& ๎ari )-a% %.r๎.-+%๎ Ja๎4a๎ ๎i-.ri&a๎ -.r๎ama@๎ama ๎.๎4a๎ 4aram -.๎i ๎a๎ )-a% ๎i+r.%i& 4)()๎4a๎ %ia?i๎a๎ D.๎4a๎ ๎ar'ari๎ ๎a*a% m.๎4,am-a% m.%a-)(i๎m. )-a% ๎i ,a%i๎
(er"atian :
Ha%i@,a%i *a๎a *.๎๎.ri%a ,i*.r๎.๎๎i%i' ๎a๎ ๎a๎i%a ,ami(๎
Hi๎๎ari *a๎a *.๎๎.ri%a 4a4a( 4i๎9a( a%a+ *.๎๎.ri%a ,i*.r+ri๎.mia a๎im*%)ma%i&๎
H.๎%i&a๎ *.๎4)-a%a๎ ๎.๎4a๎ A()*+ri๎)( -i(a %im-+( &.m.ra,a๎ &+(i% a%a+ ๎.mam๎
A((+*+ri๎)( ๎a*a% m.๎i๎4&a%&a๎ 'r.&+.๎๎i ๎.ra๎4a๎ ar%ri%i๎ 4)+% a&+%5 ๎.-ai&๎!a )-a% a๎%i i๎'(ama๎i a%a+ &)(&i๎i๎ ๎i-.ri&a๎ ย -.r๎ama *a๎a a๎a( %.ra*i๎ Ha%i@,a%i -i(a ๎i-.ri&a๎ -.r๎ama ๎.๎4a๎
๎i๎ara-i๎๎
Simpan #i tempat sejuk #an kering)
*o) +eg) DKL๎,!!๎!!๎๎!A๎
๎A+.S D%*GA* +%S%( D'K/%+ย (/) Anim ("arma
VII๎ DAFTAR PUSTAKA
Dir.&%)ra% J.๎๎ra( Bi๎a K.'arma๎ia๎ ๎a๎ A(a% &.๎.,a%a๎๎201/๎ย Farmakope ย Indonesia "disi V. K.m.๎%ria๎ K.๎.,a%a๎ I๎๎)๎.๎ia๎Ja&ar%a
S+&a๎๎ar5 E๎๎ ๎&&๎<200๎ =๎ ย Iso Farmakoterapi. Ja&ar%a: PT๎ISFI P.๎.r-i%a๎๎
ย Nia?i5 Sar'ara? K๎5 200๎ย , Handbook of Pharmace๎tica! &an๎fact๎rin'ย ย Form๎!ations, ๎econd "dition Vo!๎me One ๎ 8)m*r.๎๎.๎ S)(i๎ Pr)๎+>%๎5
I๎')rma ,.a(%,>ar.5 N.๎ ๎)r&ย
R)๎.5 R๎8๎5 S,.>&.!5 P๎J๎5 a๎๎ ๎+i๎๎5 M๎E๎5 200๎ย , Handbook ofย ย Pharmace๎tica! "#cipients, ๎i#th "dition, P,arma>.+%i>a( Pr.๎๎ a๎๎
