Efek Petidin Terhadap Psikomotorik dan Fungsi Kognitif pada Mencit (Mus musculus L.) Cemas dengan Menggunakan Alat Sistem Otomatis IntelliCage

(1)

LAMPIRAN

LAMPIRAN 1. TABEL KONVERSI DOSIS (Paget and Barnes, 1964).

Mencit 20 g

Tikus 200 g

Marmut 400 g

Kelinci 1,5 kg

Kucing 1,5 kg

Kera 4 kg

Anjing 12 kg

Manusia 70 kg

Mencit 20 g

1,0 7,0 12,23 27,80 29,7 64,10 124,20 387,9

Tikus 200 g

0,14 1,0 1,74 3,9 4,20 9,20 17,80 56,0

Marmut 400 g

0,08 0,57 1,0 2,25 2,40 5,20 10,20 31,50

Kelinci 1,5 kg

0,04 0,25 0,44 1,0 1,08 2,40 4,50 14,20

Kucing 1,5 kg

0,03 0,23 0,41 0,92 1,0 2,20 4,10 13,0

Kera 4 kg

0,016 0,11 0,19 0,42 0,43 0,1 1,9 6,1

Anjing 12 kg

0,008 0,06 0,l0 0,22 1,24 0,52 1,0 3,10

Manusia 70 kg

0,0026 0,018 0,031 0,07 0,076 0,16 0,32 1,0

(2)

Lampiran 2. Data

2.1. Data Durasi Kunjungan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

Corner/sudut Corner/sudut Corner/sudut Corner/sudut

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 40.727 7.987 26.287 0 0 7.02 26.454 0 0 31.529 19.344 0 4.274 6.63 0

Pembelajaran

2 0 38.904 18.081 28.247 0 6.256 31.684 23.695 0.499 1.669 25.564 20.296 0 0 18.469 0

Conditioning 1 0 14.415 30.5 119.526 0 4.92 17.551 226.709 1.077 0 0 117.804 0 77.329 148.038 119.182

Conditioning 2 0 0 20.201 23.244 0 0 44.07 29.177 0 0 16.878 14.383 0 0 5.07 18.985

Treatment 1 1.123 88.701 2.917 168.172 0 4.711 24.736 194.845 6.802 24.15 172.413 94.133 6.568 0 68.5 206.85

Treatment 2 0 7.399 45.365 55.33 0 1.919 49.657 55.333 1.919 49.657 26.552 0 17.286 3.526 306.705

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 7.394 6.313 0 0 0 20.312 0 8.72 24.617 26.349 11.173 10.173 12.542

Pembelajaran

2 0 0 6.147 12.605 0 0 0 41.875 0 2.684 13.588 8.284 0 0 5.897 17.598

Conditioning 1 0 17.113 30.448 23.651 0 0 55.993 314.806 0 12.372 157.556 112.445 0 1.919 0 11.432

Conditioning 2 0 0 6.832 12.261 0 0 3.647 3.853 0 0 13.962 0 0 0 8.446 1.999

Treatment 1 0 4.381 0 2.73 10.375 5.382 33.769 51.302 6.802 24.15 172.413 58.959 0 0 27.238 20.722

Treatment 2 0 1.422 31.117 50.881 0 3.651 9.968 11.543 0 20.889 64.024 59.814 0 6.1 0 79.701

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 112.57 29.063 0 125.893 0 8.736 0 12.059 34.32 16.115 0 22.325 3.135 12.125

Pembelajaran 0 0 8.966 28.625 14.498 30.537 30.558 36.254 0 0 20.977 13.292 5.055 14.819 25.257 15.678

(3)

2

Conditioning 1 0 1.872 176.249 73.787 22.323 3.338 881.193 229.138 1.95 4.96 347.093 391.944 3.526 3.37 41.745 108.531

Conditioning 2 0 0 8.035 45.333 0 0 20.732 105.535 0 0 25.273 63.756 0 0 2.153 3.51

Treatment 1 4.742 4.65 155.753 214.407 10.375 101.773 17.051 207.265 555.756 16.011 72.978 126.936 15.897 18.69 39.813 90.311 Treatment 2 130.805 24.57 113.344 22.637 38.579 28.344 21.45 22.637 0 111.162 24.57 81.121 0 0 0 12.978

2.2. Data Mentah Durasi Hendusan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 2.153 3.163 0 0 3.182 1.95 0 0 9.345 5.928 0 0 1.884 0

Pembelajaran

2 0 3.167 3.182 9.449 0 0 6.226 7.027 0 0 0 3.26 0 0 3.884 0

Conditioning 1 0 0 10.405 18.207 0 0 2.913 122.109 0 0 23.676 47.619 0 4.691 94.552 85.984

Conditioning 2 0 0 1.716 12.09 0 0 2.168 11.684 0 0 2.512 4.973 0 0 0 2.751

Treatment 1 0 0 51.96 90.511 0 0 3.755 133.314 0 3.728 68.219 15.924 0 0 35.928 141.4

Treatment 2 0 2.912 104.31 34.56 18.96 0 6.185 20.103 0 0 0.562 2.933 0 2.164 0 196.563

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 2.933 2.09 0 0 3.229 0 0 0 9 0.671 0 0 0.187 0

Pembelajaran

2 0 0 2.998 6.398 0 0 3.245 5.491 0 0 0 0 0 0 0 3.245

Conditioning 1 0 2.106 0.483 3.214 0 0 3.214 84.411 0 3.158 0 15.335 0 0 0 0

Conditioning 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Treatment 1 0 0 0 0 0 0 4.567 3.978 0 0 0.468 8.862 0 0.593 5.133 5.019

Treatment 2 0 0 7.201 5.008 0 3.182 0 0 0 0 0 0 0 0 11.089 13.631

(4)

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 4 5

Pembelajaran

1 0 0 5.304 1.139 0 3.198 0 0.203 0 0.312 3.089 11.402 0 0 0.53 12.044

Pembelajaran

2 0 3.198 1.997 0 0 3.26 0.359 3.26 0 0 2.636 0 0 3.198 11.876 3.182

Conditioning 1 0 9.5 98.954 37.846 0 0 13.948 100.21 0 0 130.741 164.782 0 0 19.917 29.698

Conditioning 2 0 0 0 0.858 0 0 4.986 62.874 0 0 0 17.232 0 0 0 0

Treatment 1 0 0 70.344 126.814 0 66.649 5.507 145.357 0 0 0 90.948 0 6.139 26.474 38.034

Treatment 2 0 101.425 0 6.006 0 3.112 0 43.718 0 2.203 0.694 0 0 2.252 0 0

2.3. Data Mentah Durasi Jilatan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 5.678 9.999 0 0 4.727 13.098 0 0 2.107 6.584 0 0.25 4.415 0

Pembelajaran

2 0 0 4.243 8.416 0 0 5.976 9.358 0 0 4.212 1.579 0 0 4.243 9.406

Conditioning 1 0 0 15.73 107.084 0 0 7.456 154.253 0 0 34.007 72.306 3.116 11.327 121.403 95.393

Conditioning 2 0 0 5.35 11.498 0 0 12.18 18.252 0 0 0.608 9.305 0 0 3.838 52.217

Treatment 1 0 0 65.251 101.93 0 0 13.605 154.9 5.038 12.86 112.5 38.434 1.824 0 40.247 188.916

Treatment 2 0 1.779 17.463 28.508 0 0 14.43 24.21 0 0 13.554 5.975 0 1.201 3.937 264.214

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 4.243 8.416 0 0 5.976 9.358 0 0 4.212 1.579 0 0 2.77 7.899

Pembelajaran 0 4.618 10.14 7.466 0 0 10.194 206.34 124.723 26.093 0 0 2.091 1.498

(5)

2

Conditioning 1 0 0 0.997 2.34 0 0 3.659 1.856 0 0 2.932 0 0 0 3.069 0.357

Conditioning 2 0 0.147 0 0.624 0 1.638 7.027 8.093 0 3.977 44.895 24.013 0 0 12.732 9.262

Treatment 1 0 4.886 14.665 14.598 0 1.154 3.36 0.715 0 6.286 11.402 11.463 0 0 16.38 13.717

Treatment 2 0 0 5.272 4.415 0 0 9.5 3.946 0 0 3.853 5.52 0 0 0 3.462

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 4 5

Pembelajaran

1 0 3.76 8.447 3.839 0 0 7.454 16.254 0 0 8.972 4.588 0 4.04 16.271 6.037

Pembelajaran

2 0 13.447 130.714 46.649 0 0.298 26.391 206.26 0 3.243 260.536 258.539 0 0 30.576 73.557

Conditioning 1 0 0 1.029 8.711 0 0 15.799 74.766 0 0 14.274 25.975 0 0 0.702 1.498

Conditioning 2 1.31 1.17 110.035 139.141 1.31 76.497 8.343 161.175 0.531 3.146 9.6 101.902 0 9.111 44.281 48.396

Treatment 1 0 121.584 10.596 14.182 0 74.489 9.218 43.222 8.76 6.707 5.49 2.681 0 0 3.588 2.637

Treatment 2 0 0 20.094 7.691 0 6.049 0 4.65 0 0 3.323 7.301 0 0 0 9.406

2.4. Data Mentah Jumlah Kunjungan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 3 1 3 0 0 1 2 0 0 4 2 0 1 1 0

Pembelajaran

2 0 5 3 6 0 2 5 4 0 2 5 4 0 0 4 0

Conditioning 1 0 1 3 9 0 2 3 28 1 0 0 29 0 5 12 9

Conditioning 2 0 0 3 5 0 0 7 6 0 0 4 3 0 0 2 2

Treatment 1 0 2 5 8 0 1 9 6 0 8 15 31 0 4 1 19

Treatment 2 1 1 10 32 0 1 4 12 1 4 25 23 1 0 10 8

(6)

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 1 1 0 0 0 4 0 2 2 3 1 2 2 2

Pembelajaran

2 0 0 1 3 0 0 3 8 0 1 4 2 0 0 1 2

Conditioning 1 0 4 9 7 0 0 13 26 0 3 9 20 0 1 0 2

Conditioning 2 0 0 3 3 0 0 1 1 0 0 2 0 0 0 2 1

Treatment 1 0 1 5 9 0 1 2 3 0 4 10 13 0 1 11 11

Treatment 2 0 1 0 1 2 1 8 12 0 5 16 14 0 0 5 4

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 4 5

Pembelajaran

1 0 0 5 3 0 0 3 1 0 2 5 2 7 3 1 2

Pembelajaran

2 0 0 1 3 11 7 2 7 0 0 4 3 2 2 5 3

Conditioning 1 0 1 12 9 4 2 13 23 1 2 25 20 2 1 5 7

Conditioning 2 0 1 3 3 0 0 4 9 0 0 4 6 0 0 1 1

Treatment 1 0 8 4 15 2 8 4 6 0 8 4 5 0 0 0 3

Treatment 2 1 1 12 7 1 4 5 16 6 4 5 8 2 3 8 17

(7)

2.5. Data Mentah Jumlah Hendusan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 4 9 0 0 2 6 0 0 35 5 0 1 1 0

Pembelajaran

2 0 1 8 7 0 3 7 11 0 0 8 9 0 0 6 0

Conditioning 1 0 3 12 11 0 3 6 34 0 0 28 19 0 0 18 16

Conditioning 2 0 0 4 8 0 0 4 7 0 0 1 4 0 0 1 11

Treatment 1 0 0 19 46 0 0 4 22 0 13 62 30 0 0 4 13

Treatment 2 0 1 6 8 0 6 2 8 0 0 18 13 3 2 34

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 1 2 0 0 6 4 0 0 4 9 0 0 1 2

Pembelajaran

2 0 0 1 2 0 0 3 10 0 0 5 4 0 0 0 9

Conditioning 1 0 0 7 6 0 2 18 55 0 0 13 0 0 0 1 1

Conditioning 2 0 0 0 8 0 0 3 2 0 0 3 0 0 0 0 0

Treatment 1 0 0 3 3 3 2 25 27 0 2 26 32 0 0 5 5

Treatment 2 0 2 11 15 0 1 6 1 0 2 14 19 0 0 8 23

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 4 5

Pembelajaran

1 0 0 22 6 0 0 0 0 0 1 11 6 0 1 3 3

Pembelajaran 0 1 4 2 26 2 8 23 0 0 65 0 0 0 5 5

(8)

2

Conditioning 1 0 6 15 8 0 0 4 31 0 2 66 96 0 0 8 24

Conditioning 2 0 0 2 12 0 0 10 16 0 0 11 15 0 0 2 1

Treatment 1 1 1 30 22 0 11 5 21 0 2 7 18 1 3 17 20

Treatment 2 0 12 13 40 0 23 9 8 14 5 9 2 0 39 0 0

2.5. Data Mentah Jumlah Jilatan

Fase

ULANGAN

K1 (U1) K1 (U2) K1 (U3) K1 (U4)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 14 29 0 0 1 40 0 0 35 60 0 1 13 0

Pembelajaran

2 0 36 34 75 0 8 51 67 0 0 0 0 0 0 41 0

Conditioning 1 0 0 98 414 0 0 16 507 0 0 269 148 0 0 759 455

Conditioning 2 0 0 18 28 0 0 43 86 0 0 38 53 0 0 0 23

Treatment 1 0 0 493 816 0 0 24 830 0 33 645 160 0 0 327 1110

Treatment 2 0 3 50 130 0 0 61 111 0 0 0 28 0 33 224 819

Fase

ULANGAN

K2 (U5) K2 (U6) K2 (U7) K2 (U8)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4

Pembelajaran

1 0 0 26 14 0 0 26 0 0 0 3 3 0 0 0 0

Pembelajaran

2 0 0 21 61 0 0 33 48 0 0 0 0 0 0 0 30

Conditioning 1 0 0 3 33 0 29 0 1367 0 0 296 87 0 0 0 0

Conditioning 2 0 0 0 2 0 0 0 0 0 0 5 1 0 0 0 0

Treatment 1 0 0 0 0 0 21 22 79 0 3 28 73 0 0 35 46

Treatment 2 0 30 109 45 0 0 0 0 0 0 0 0 0 0 41 92

(9)

Fase

ULANGAN

K3 (U9) K3 (U10) K3 (U11) K3 (U12)

1 2 3 4 1 2 3 4 1 2 3 4 1 2 4 5

Pembelajaran

1 0 0 90 6 0 0 0 0 0 2 28 54 0 0 4 49

Pembelajaran

2 0 31 20 0 0 33 19 32 0 0 12 5 0 0 80 29

Conditioning 1 0 86 428 204 0 0 664 344 0 2 1012 477 0 0 146 260

Conditioning 2 0 0 0 0 0 0 60 419 0 0 27 61 0 0 0 0

Treatment 1 0 0 501 568 0 280 57 755 0 0 0 0 27 50 288 428

Treatment 2 0 417 0 84 0 698 23 155 0 1 14 1 0 38 0 0

(10)

LAMPIRAN 3. Data Uji Statistik One Way ANNOVA-

Bonferroni

ANOVA

Sum of

Squares

df

Mean Square

F

Sig.

Durasi_Kunjungan

Between

Groups

47636.178

2 23818.089

2.596 .086

Within Groups 412903.247

45 9175.628

Total

460539.425

47 Durasi_Hendusan

Between

Groups

12009.479

2 6004.739

3.756 .031

Within Groups 71944.524

45 1598.767

Total

83954.003

47 Durasi_Jilatan

Between

Groups

15690.658

2 7845.329

3.373 .043

Within Groups 104653.166

45 2325.626

Total

120343.824

47 Jumlah_Kunjungan

Between

Groups

72.542

2

36.271 .986

.381

Within Groups

1655.375

45

36.786 Total

1727.917

47 Jumlah_Hendusan

Between

Groups

210.667

2

105.333 .547

.582

Within Groups

8658.813

45

192.418 Total

8869.479

47 Jumlah_Jilatan

Between

Groups

546432.167

2 273216.083

3.956 .026

Within Groups 3107849.750 45

69063.328

Total

3654281.917 47

(11)

Multiple Comparisons

95% Confidence

Interval

Kontrol

Saline

40.39988 33.86670 .717

-43.8192

124.6189

Petidin

Saline

Kontrol

-40.39988 33.86670 .717

Petidin

Kontrol

36.73669 33.86670 .851

-47.4824

120.9557

Saline

77.13656 33.86670 .083 -7.0825 161.3556

Durasi_Hen

dusan

Kontrol

Saline

32.45744 14.13669 .079 -2.6974

67.6123

Petidin

-2.09544 14.13669

1.00

0 -37.2503

33.0594

Saline

Kontrol

-32.45744 14.13669 .079

-67.6123

2.6974

Petidin

-34.55288 14.13669 .056

-69.7077

.6020

Petidin

Kontrol

2.09544 14.13669

1.00

0 -33.0594

37.2503

Saline

34.55288 14.13669 .056

-.6020

69.7077

Durasi_Jilat

an

Kontrol

Saline

39.06856 17.05002 .080 -3.3311

81.4682

Petidin

1.47231 17.05002

1.00

0 -40.9273

43.8720

Saline

Kontrol

-39.06856 17.05002 .080

-81.4682

3.3311

Petidin

-37.59625 17.05002 .098

-79.9959

4.8034

Petidin

Kontrol

-1.47231 17.05002

1.00

0 -43.8720

40.9273

Saline

37.59625 17.05002 .098 -4.8034

79.9959

Jumlah_Ku Kontrol

Saline

2.43750

2.14436 .785 -2.8950

7.7700

(12)

njungan

Petidin

2.75000

2.14436 .619 -2.5825

8.0825

3.50000

4.90431

1.00

0 -8.6959

15.6959

Saline

Kontrol

-5.00000

4.90431 .940

-17.1959

7.1959

Petidin

-1.50000

4.90431

1.00

0 -13.6959

10.6959

Petidin

Kontrol

-3.50000

4.90431

1.00

0 -15.6959

8.6959

Saline

1.50000

4.90431

1.00

0 -10.6959

13.6959

Jumlah_Jila

tan

Kontrol

Saline

258.00000

*

92.91349 .024 26.9446 489.0554

165.12500

92.91349 .247

-396.180

4 65.9304

Petidin

Kontrol

-92.87500 92.91349 .969

65.9304

396.1804

*. The mean difference is significant at the 0.05 level.

(13)

Lampiran 4. Foto Penelitian

4.1.Foto Alat

Timbangan Digital

Injector Transponder

IntelliCage

Hand Scanner

Microtransponder

Komputer (PC)

(14)

4.2.Foto Bahan

Petidin, Saline dan Ketamin

Mencit (Mus musculus)

4.3. Foto Kerja

Menimbang Mencit

Mengambil Ketamin

Implantasi Transponder

Scanning nomor Transponder

(15)