Mark Moss, UK Yoshiharu Motoo, Japan Frauke Musial, Germany MinKyun Na, Republic of Korea Richard L. 2Department of Clinical Oncology, College of Korean Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
Acupuncture and Herbal Medicine for Cancer Patients
The reasons for this may be the expected inflexibility of medical oncologists and patients' fear of damaging the relationship with oncologists due to the use of CAM. Although it is difficult to obtain a patent for natural products, further interest from pharmaceutical companies could be limited.
Eguchi et al., "Nationwide survey on complementary and alternative medicine in cancer patients in Japan," Journal of Clinical Oncology, vol. Pud et al., "Use of complementary and alternative medicine in cancer patients: a European survey," Annals of Oncology, Vol.
A Survey of Chinese Medicinal Herbal Treatment for Chemotherapy-Induced Oral Mucositis
- Introduction
- Methods
- Results
- Single Herbs or Single Herbal Compounds
- Herbal Combinations
- Discussion
- Conclusion
The incidence of mucositis was 13.1% in the herbal treatment group and 39.1% in the control group. Improvement of oral mucositis symptoms was found in 96.7% of the herbal treatment group, compared to 86.7% in the control group.
Conflict of Interests
Lee et al., “Regulatory effects of Codonopsis lanceolata on macrophage-mediated immune responses,” Journal of Ethnopharmacology , vol. Kim et al., “Alismatis rhizome ethanol extract reduces acute lung inflammation by inhibiting NF-kappaB and activating Nrf2,” Journal of Ethnopharmacology , vol.
Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling
Materials and Methods
Approximately 5 × 105 cells were incubated in different concentrations of hispidulin for the indicated time. Expression of 𝛽-actin was used as an internal control. e) Western blot analysis to analyze apoptosis-related proteins and 48 hours after treatment.
Discussion
AGS cells treated with 25–50 M PD98059 and NAG-1 expression was evaluated by Western blot analysis. Results from analyzes of COX-2 protein expression in AGS cells after their treatment with Hispidulin showed that Hispidulin induced morphological changes in the AGS cells (data not shown), inhibited AGS cell growth (Figure 1(a) ), and arrested the cell cycle at the G1/S phase (Figure 3(a)).
Authors’ Contribution
The p21 can help maintain G1 cell cycle arrest by inactivating the cyclin D1/cyclin E complex, which leads to the phosphorylation of the Rb protein. These results suggested that a caspase-dependent pathway mediates Hispidulin-induced apoptosis (Figures 2(d)–2(e) ) and cell death.
Acknowledgments
Tsai et al., "Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)," Journal of Agricultural and Food Chemistry, vol. Houde et al., "Aspirin inhibits mTOR signaling, activates AMP- activated protein kinase and induces autophagy in colorectal cancer cells,” Gastroenterology , vol.
Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Four-Arm Randomized Trial on
- Background
- Outcomes
- Statistics
- Results
Bergman et al., “European Organization for Research and Treatment of Cancer QLQ-C30: a quality of life instrument for use in international oncology clinical trials,” Journal of the National Cancer Institute, vol. Merkies et al., “Chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to first findings of validity and reliability,” Annals of Oncology , vol.
Can Medical Herbs Stimulate Regeneration or Neuroprotection and Treat Neuropathic Pain in
Sven Schröder, 1,2 Kathrin Beckmann, 1 Giovanna Franconi, 3 Gesa Meyer-Hamme, 1
Thomas Friedemann, 1 Henry Johannes Greten, 2 Matthias Rostock, 4 and Thomas Efferth 5
Conclusion
Koutras et al., “Preventing paclitaxel-induced peripheral neuropathy: a phase II trial of vitamin E supplementation,” Journal of Pain and Symptom Management, vol. Nagira et al., “Herbal drug Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice,” European Journal of Pain, vol.
A Systematic Review of Experimental and Clinical Acupuncture in Chemotherapy-Induced Peripheral Neuropathy
Giovanna Franconi, 1 Luigi Manni, 2 Sven Schröder, 3 Paolo Marchetti, 4,5 and Nicola Robinson 6
Methodology
Jia, “The curative effect of warm acupuncture and moxibustion on oxaliplatin-induced peripheral neurotoxicity,” Tianjin Journal of Traditional Chinese Medicine , vol. Li et al., “Effects of opioid receptor antagonists on electroacupuncture-induced antiallodynia/hyperalgesia in rats with paclitaxel-induced peripheral neuropathy,” Brain Research , vol. Marmiroli, “The role of growth factors in the prevention and treatment of chemotherapy-induced peripheral neurotoxicity,” Current Drug Safety, vol.
Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
It was a striking feature that genes with different functions correlated with the response of NCI cell lines to phytochemicals (verbascoside, apigenin, emodin, quercetin, eriodictyol and resveratrol). Kaltner, "Early tadpole embryo culture: induction of embryogenesis under in vitro conditions," The Journal of Experimental Zoology, vol. Vinikoor et al., “Integration of global gene expression and radiation survival parameters across 60 cell lines of the National Cancer Institute Anticancer Screen,” Cancer Research , vol.
Chinese Medicines as an Adjuvant Therapy for Unresectable Hepatocellular Carcinoma during
Transarterial Chemoembolization: A Meta-Analysis of Randomized Controlled Trials
Zhao, “Clinical observation of Ai Di injection combined with transarterial chemoembolization in the treatment of 33 patients with hepatocellular carcinoma,” Zhongguo Zhong Yi Yao Xin Xi Za Zhi , vol. Lu, “Clinical trial of Chinese herbal medicine combined with transarterial chemoembolization in the treatment of primary hepatocellular carcinoma,” Zhongguo Zhong Xi Yi Jie He Za Zhi , vol. Meng, “Clinical observation of Ai Di injection combined with transarterial chemoembolization in the treatment of hepatocellular carcinoma,” Zhongguo Zhong Yi Ji Zheng, vol.
Distributions of Usage and the Costs of Conventional
Medicine and Traditional Chinese Medicine for Lung Cancer Patients in Taiwan
Conclusions
Our study reports the prevalence and pattern of TCM use under NHI, a comprehensive and universal health insurance program in Taiwan. The prevalence of TCM use among lung cancer patients who underwent and did not undergo surgery is similar. This study provides information on the frequency of TCM use and the coexisting diseases treated by WM and TCM in lung cancer patients according to surgery status.
Acknowledgment
Kung et al., “Use frequency of traditional Chinese medicine in Taiwan,” BMC Health Services Research, vol. Huang, “Usage patterns of Chinese medicine and Western medicine under the National Health Insurance Program in Taiwan, a population-based study from 1997 to 2003,” BMC Health Services Research , vol. Chiu, “Prevalence, patterns, and costs of Chinese medicine use among prostate cancer patients: a population-based study in Taiwan,” Integrative Cancer Therapies , vol.
Cytotoxicity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
Material and Methods
Only the mRNA expression levels but not the IC50 values of the compounds for the cell line panel. Yoo et al., "Use of traditional medicine and folk medicine for hypertensive patients: based on Cheonan practice-based research network," Journal of the Korean Academy of Family Medicine, vol. Johnson et al., "Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns,” Journal of the National Cancer Institute , vol.
Therapeutic Applications of Herbal Medicines for Cancer Patients
- Clinical Uses of Herbal Medicine with Anticancer Effects
- Use of Herbal Supplements as Adjuvants in Conventional AntiCancer Therapies
- Evidence of the Effect of Herbal Medicines in Randomized Controlled Trials
- Other Anticancer Applications of Specific Herbal Medicines
- Conclusion and Future Development
Kobayashi et al., “Soy, isoflavones, and breast cancer risk in Japan,” Journal of the National Cancer Institute, vol. Tangen et al., “Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E (SELECT) Cancer Prevention Study,” The Journal of the American Medical Association, vol. Quality of reporting of randomized controlled trials of herbal medicine interventions”, The American Journal of Medicine, vol.
Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial
- The Representative CHM Formula in Basic Research
- The Representative CHM Formula in Clinical Research
- The Representative CHM Single Herb in Basic Research
- The Representative CHM Single Herb in Clinical Research
- The Effects of Detoxification and
To evaluate the effect of combination therapy with TACE and JDF granule preparation in the treatment of patients with unresectable HCC on survival, the current study data showed that TACE combined with JDF granule preparation can improve the prognosis of patients and prolong the survival of patients with unresectable HCC [17]. In order to effectively prevent the recurrence of HCC after surgical resection, a control trial was conducted, Jiedugranules, CHM compound and cinobufacinium injection extracted from the skin of Bufo bufo gargarizans Cantor after surgery compared with TACE after surgery. JieduGranule is composed of CHM, Herba Salviae Chinensis, Radix Actinidiae valvatae, Semen Coicis, Fructus Crataegi, Massa Medicata Fermentata and Fructus Hordei Germinatus. Trials have shown that Jiedugranule and cinobufacinium injection, a combination commonly used for postoperative treatment of HCC, can delay tumor recurrence and metastasis, prolong survival time, and increase the survival rate of postoperative HCC patients [18]. CHM, including animal and plant herbs, plays an important role in the treatment of malignancy, including HCC.
Enhancement for Chemotherapy on CHM
Side Effects of CHM
Conclusions
Guan et al., “Traditional Chinese medicine plus transcatheter arterial chemoembolization for irreversible hepatocellular carcinoma,” Journal of Alternative and Complementary Medicine, vol. Peng et al., “Bufalin increases susceptibility to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells,” International Journal of Oncology , vol. Qi et al., “Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling,” International Journal of Oncology , vol.
Role of Kampo Medicine in Integrative Cancer Therapy
Limitations of Standard Cancer Treatment
Cancer treatment will increasingly require approaches that enable patients to live with cancer by enhancing their natural healing power and resistance to tumors and by reducing cancer progression rather than attacking cancer cells [19–21]. Complementary and alternative medicine, including Kampo medicine [22–25], compensates for the shortcomings of Western medicine by increasing the healing power and resistance of the body [26–29]. The goal of holistic treatment or holistic care is not only to kill cancer cells, but also to address the body's healing powers and resilience.
Surveys of the Use of Kampo in Cancer Treatment in Japan
Camp therapy can provide very useful therapeutic options to achieve holistic therapy and multidisciplinary cancer treatment [30–36].
The Role of Kampo Medicine in
Multidisciplinary Treatment of Cancer
Juzentaihoto: A Typical Kampo Formula for Cancer Treatment
Important Precautions: (1) When using this product, the patient's “sho”. constitution and symptoms) must be taken into account. The patient's progress should be carefully monitored and if no improvement in symptoms or findings is observed, continued treatment should be avoided. The hospital reports that Kampo drugs have been authorized for prolonging the lives of cervical cancer patients.
Summary
Terasawa, “Evidence-based reconstruction of Kampo medicine: part II-the concept of Sho,” Evidence-Based Complementary and Alternative Medicine, vol. Imazu et al., “First Nationwide Attitude Survey among Japanese Physicians on the Use of Traditional Japanese Medicine (Kampo) in Cancer Treatment,” Evidence-Based Complementary and Alternative Medicine, vol. Asano et al., “Suppressive effect of Juzentaihoto on vascularization induced by B16 melanoma cells in vitro and in vivo,” Evidence-Based Complementary and Alternative Medicine, vol.
Hemiparesis after Operation of Astrocytoma Grade II in Adults: Effects of Acupuncture on
Haibo Yu, 1 Sven Schröder, 2 Yongfeng Liu, 1 Zhifeng Li, 1 Ying Yang, 1 Yu Chen, 1 and Xingxian Huang 1
Tan et al., “Effect of acupuncture on stroke recovery: study protocol for a randomized controlled trial,” BMC Complementary and Alternative Medicine , vol. Muller et al., “Development and psychometric validation of a brain cancer quality of life questionnaire for use in combination with general cancer-specific questionnaires,” Quality of Life Research , vol. Luo et al., “Effect of electroacupuncture on Ren and Du vessels in hippocampal horizontal cells of focal cerebral ischemia,” China Medical Herald , vol.
Integration of Different ‘‘-omics’’ Technologies Identifies
Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells
Results
To gain deeper insight into the molecular modes of action of shikonin in U937 cells, three "-omics". We performed a virtual screening approach to identify potential targets of shikonin in the PI3K-mTOR pathway. The dose-response curve of shikonin on IGF1R activity clearly shows a dose-dependent inhibition of the kinase after shikonin application (Figure 5).
Discussion
Additional inhibition of EGFR signaling makes shikonin even more valuable for targeting the PI3K/mTOR cascade, as another important entry point of the pathway is eliminated. In addition to deregulation of the PI3K-Akt-mTOR signaling cascade, we have recently shown that shikonin directly targets the mitochondria of cancer cells and thereby triggers apoptosis [7]. A radiometric protein kinase assay (33PanQinase Activity Assay) was used to measure IGF1R kinase activity.
Materials and Methods
Buchdunger et al., “Effects of a Selective Ab1 Tyrosine Kinase Inhibitor on the Growth of Bcr-Ab1 Positive Cells,” Nature Medicine, vol. Edlind et al., "The translational landscape of mTOR signaling directs cancer initiation and metastasis," Nature, vol. Pollak, “The insulin and insulin-like growth factor receptor family in neoplasia: an update,” Nature Reviews Cancer , vol.
Significance of Kampo, Traditional Japanese Medicine, in Supportive Care of Cancer Patients
Kampo for Chemotherapy-Induced Peripheral Neuropathy
The use of the preparation Kampo goshajinkigan [57-67] as drug therapy for symptoms of peripheral neuropathy has been widely reported in Japan. Goshajinkigan extract preparation has been reported to relieve symptoms such as numbness or pain in 80% of cases in which it is used for paclitaxel-induced peripheral neuropathy for breast cancer [68]. Goshajinkigan also improves the subjective symptoms of peripheral neuropathy due to the combined use of paclitaxel and carboplatin for ovarian or uterine cancer.
Kampo for Chemotherapy-Induced Diarrhea
SN-38 formed in the liver is glucuronidated by a glucuronidation enzyme also present in the liver. It is thought that this SN-38 formed in the digestive tract then damages intestinal mucosal epithelial cells, giving rise to delayed diarrhea. The flavonoid glycoside baicalin can control irinotecan hydrochloride-induced diarrhea because it actively inhibits 𝛽-glucuronidase of the intestinal flora and suppresses the reformation of the active form (SN-38) in the digestive tract.
Conclusions
Chisato et al., "Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer," Evidence-Based Complementary and Alternative Medicine, vol. Ren et al., "Gosha-jinki-gan (a herbal complex) corrects abnormal insulin signaling ,” Evidence-Based Complementary and Alternative Medicine, vol. Chisato et al., “Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer,” Evidence-Based.
