ADDENDUM
Table 1. Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) classification
Class GFR criteria Urine output criteria
Risk Serum creatinine × 1.5 < 0.5 ml/kg/hour × 6 hours Injury Serum creatinine × 2 < 0.5 ml/kg/hour × 12 hours Failure
Serum creatinine × 3, or serum creatinine ≥ 4 mg/dl with an acute rise > 0.5 mg/dl
< 0.3 ml/kg/hour × 24 hours, or anuria × 12 hours
Loss Complete loss of kidney function > 4 weeks End-stage kidney
disease Complete loss of kidney function > 3 months Renal recovery
Complete Recovery Partial Recovery
Patient returns to baseline classification within RIFLE criteria Persistent change in RIFLE classification but not persistent need for RRT
Multiply by 88.4 to convert creatinine to µmol/l. Glomerular filtration rate (GFR) criteria are calculated as an increase of serum creatinine above the baseline serum creatinine level. In patients without a history of chronic kidney disease and unknown baseline serum creatinine, it is recommended calculating a baseline serum creatinine using the Modification of Diet in Renal Disease equation, assuming a GFR of 75 ml/min/1.73 m2 (see Methods). AKI should be both abrupt (within 1–7 days) and sustained (more than 24 hours).
ADDENDUM
Table 2. Estimated baseline creatinine.
Age (years) Black males (mg/dl)
Other males (mg/dl )
Black females (mg/dl)
Other females (mg/dl)
20–24 1.5 1.3 1.2 1.0
25–29 1.5 1.2 1.1 1.0
30–39 1.4 1.2 1.1 0.9
40–54 1.3 1.1 1.0 0.9
55–65 1.3 1.1 1.0 0.8
>65 1.2 1.0 0.9 0.8
Estimated glomerular filtration rate = 75 (ml/min per 1.73 m2) = 186 × (serum creatinine [SCr])
- 1.154 × (age) - 0.203 × (0.742 if female) × (1.210 if black) = exp(5.228 - 1.154 × In [SCr]) –
0.203 × In(age) - (0.299 if female) + (0.192 if black) (see Methods).
