Supplemental Table 1. Demographics and clinical characteristics of patients with and without acute kidney.
AKI- (n=21)
AKI+
(n=110) p-value
Sex (male) 11 (52.4) 55 (50.9) 0.90
Age (days) 21 (5, 190) 30 (9, 264) 0.32
Weight (kg) 3.4 (2.9, 6.4) 3.7 (3.1, 7.8) 0.49
%FO at ECMO initiation 7.9 (0, 10.7) 11 (0.2, 25.8) 0.32
%FO at ECMO discontinuation 8.4 (3.4, 28.1) 19.3 (4.8, 46) 0.46
CRRT 9 (42.9) 64 (58.2) 0.20
MV duration (days) 180 (127.5, 344) 139 (90, 343.5) 0.77 Hospital LOS (days)§ 40 (21, 70) 49 (23, 62) 0.73
Mortality (yes) 9 (52.9) 62 (56.4) 0.26
§among survivors (n=60). Continuous variables are presented as median with interquartile range (IQR).
Categorical variables are presented as counts with percentage (%). Mechanical ventilation duration and length of stay were assessed among survivors only. Abbreviations: kg=kilogram, %FO=percent fluid overload,
ECMO=extracorporeal membrane oxygenation, CRRT=continuous renal replacement therapy, MV=mechanical ventilation, LOS=length of stay.
Supplemental Table 2. Demographics and clinical characteristics of patients with and without severe acute kidney injury.
AKI- (n=53)
Severe AKI+
(n=78) p-value
Sex (male) 29 (54.7) 37 (48.7) 0.50
Age (days) 18 (7, 242) 34 (10, 237) 0.13
Weight (kg) 3.6 (3, 6.7) 3.7 (3, 7.8) 0.95
%FO at ECMO initiation 6.7 (0, 12.1) 13.5 (0.4, 31.1) 0.01
%peak FO during ECMO 13.9 (6.1, 36) 29.1 (12.5, 52.1) 0.02
%FO at ECMO discontinuation 11.3 (2.3, 28.1) 21 (7.4, 49.7) 0.03
CRRT 26 (49.1) 47 (60.3) 0.21
MV duration (days) 123.5 (85, 249.5) 228.5 (93, 373.5) 0.29 Hospital LOS (days)§ 34 (19, 60) 52 (31, 62) 0.09
Mortality (yes) 26 (40.1) 45 (57.7) 0.33
§among survivors (n=60). Continuous variables are presented as median with interquartile range (IQR).
Categorical variables are presented as counts with percentage (%). Mechanical ventilation duration and length of stay were assessed among survivors only. Abbreviations: kg=kilogram, %FO=percent fluid overload,
ECMO=extracorporeal membrane oxygenation, CRRT=continuous renal replacement therapy, MV=mechanical ventilation, LOS=length of stay.
Supplemental Table 3. Demographics and clinical characteristics of patients with and without fluid overload at ECMO initiation
FO- at ECMO initiation (n=67)
FO+ at ECMO initiation
(n=64) p-value
Sex (male) 27 (40.9) 39 (61.9) 0.02
Age (days) 93 (10, 501) 16 (9, 110) 0.01
Weight (kg) 4.5 (3.4, 10) 3.3 (3, 4.1) 0.001
Cardiopulmonary bypass
duration (minutes) 129 (110, 159) 126 (94, 152) 1.00
ECMO duration (hours) 88 (52, 156) 116.5 (52.5, 195.5) 0.25
AKI 57 (85.1) 62 (96.9) 0.02
MV duration (days) 104 (77, 261.5) 246 (125.5, 373.5) 0.07
CRRT 32 (47.8) 41 (64.1) 0.06
Hospital LOS (days)§ 33 (19, 54) 60 (49, 83) 0.001
Mortality (yes) 33 (49.3) 38 (59.4) 0.25
§ among survivors (n=60). Continuous variables are presented as median with interquartile range (IQR).
Categorical variables are presented as counts with percentage (%). Abbreviations: FO=fluid overload kg=kilograms, ECMO=extracorporeal membrane oxygenation, AKI=acute kidney injury, CRRT=continuous renal replacement therapy, LOS=length of stay.