Appendix 1. Search Strategy

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Dioun S, Wu J, Chen L, Kaplan S, Huang Y, Melamed A, et al. Intraoperative rupture of the ovarian capsule in early- stage ovarian cancer: a meta-analysis. Obstet Gynecol 2021;138.

The authors provided this information as a supplement to their article.

Appendix 1. Search Strategy

Topic: What are the outcomes of intra-operative capsule rupture in Early-Stage Ovarian Cancer?

Searcher: SJK Date: 8.11.2020

Database (including vendor/platform): PubMed (NLM)

Set # Results

1 Early stage ovarian cancer

"Carcinoma, Ovarian Epithelial"[Mesh] OR "Ovarian

Neoplasms"[Mesh] OR ((ovary[tiab] OR ovarian[tiab]) AND (neoplasm[tiab] OR cancer[tiab] OR cancers[tiab] OR carcinoma[tiab] OR carcinomas[tiab]))

120654

2 Ovarian cyst

"Cystadenocarcinoma, Serous"[Mesh] OR Capsule[tiab] OR

capsules[tiab] OR cyst[tiab] OR cysts[tiab] OR cystectomy[tiab] OR cystectomies[tiab] OR tumor[tiab] OR tumors[tiab] OR tumour[tiab]

OR tumours[tiab] OR mass[tiab]

2,679314

3 Rupture "Rupture"[Mesh] OR Rupture[tiab] OR ruptured[tiab] OR

spillage[tiab] OR spillages[tiab] 144754

4 1 AND 2 AND 3 648

Database (including vendor/platform): Embase (Elsevier)

Set # Results

'ovarian epithelial cancer'/exp OR 'ovary cancer'/exp OR

((ovary:ti,ab OR ovarian:ti,ab) AND (neoplasm:ti,ab OR cancer:ti,ab OR cancers:ti,ab OR carcinoma:ti,ab OR carcinomas:ti,ab))

168560

2 Ovarian cyst

'ovary cyst'/exp OR Capsule:ti,ab OR capsules:ti,ab OR cyst:ti,ab OR cysts:ti,ab OR cystectomy:ti,ab OR cystectomies:ti,ab OR tumor:ti,ab OR tumors:ti,ab OR tumour:ti,ab OR tumours:ti,ab OR mass:ti,ab

3679661

3 Rupture 'rupture'/exp OR Rupture:ti,ab OR ruptured:ti,ab OR spillage:ti,ab

OR spillages:ti,ab 213622

4 1 AND 2 AND 3 801

AND [humans]/lim 670

Database (including vendor/platform): Scopus (Elsevier)

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Set # Results

TITLE-ABS-KEY( ((ovary OR ovarian) AND (neoplasm OR cancer OR

cancers OR carcinoma OR carcinomas))) 167650

2 Ovarian cyst

TITLE-ABS-KEY(Capsule OR capsules OR cyst OR cysts OR cystectomy OR cystectomies OR tumor OR tumors OR tumour OR tumours OR mass)

6354675

3 Rupture TITLE-ABS-KEY(Rupture OR ruptured OR spillage OR spillages) 281887

4 1 AND 2 AND 3 1090

5 AND ( LIMIT-TO ( DOCTYPE , "ar" ) OR LIMIT-TO ( DOCTYPE , "re" )

OR LIMIT-TO ( DOCTYPE , "cp" ) ) 1036

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Appendix 2. Quality Assignment Based on the Newcastle-Ottawa Scale

Study Score Quality of Study

Sevelda (1989) 7 Good

De La Cuestra (1994) 7 Good

Sjovall (1994) 8 Good

Vergote (2001) 9 Good

Mizuno (2003) 8 Good

Bakkum (2009) 8 Good

Goudge (2009) 7 Good

Paulsen (2011) 9 Good

Kajiyama (2014) 7 Good

Shimizu (2015) 7 Good

Suh (2015) 7 Good

Rosendahl (2016) 8 Good

Sartorius (2018) 8 Good

Tang (2018) 7 Good

Kajiyama (2019) 7 Good

Matsuo (2019) 9 Good

Matsuo (2020) 8 Good

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Appendix 3. Meta-analysis comparing intraoperative capsule rupture on progression-free survival (PFS) based on whether or not the hazard ratio was reported (A) or estimated (B).

A. PFS in studies in which the hazard ratio was reported.

B. PFS in studies in which the hazard ratio was estimated.

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Appendix 4. Meta-analysis comparing intraoperative capsule rupture on overall survival (OS) based on whether or not the hazard ratio was reported (A) or estimated (B).

B. OS in studies in which the hazard ratio was estimated.

A. OS in studies in which the hazard ratio was repoted.

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Appendix 5. Meta-analysis comparing intraoperative capsule rupture on progression-free survival (PFS) (A) and overall survival (OS) (B) in studies after 2000.

A. PFS in studies reported after 2000.

B. OS in studies reported after 2000.

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Appendix 6. Meta-analysis comparing intraoperative capsule rupture on progression-free survival (PFS) (A) and overall survival (OS) (B) in studies with sample size >250.

A. PFS in studies with sample sizes >250 patients.

B. OS in studies with sample sizes >250 patients.

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Appendix 7. Meta-analysis comparing intraoperative capsule rupture on overall survival in studies with sample size >500.