Appendix 1. ICD-9 and ICD-10 Codes Used for Data Extraction

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Oben A, Szychowski JM, Ketch P, Elkins C, Sinkey R, Andrews WW, et al. Progression to Severe Chronic Hypertension 5–7 Years After a Pregnancy With Mild Chronic Hypertension. Obstet Gynecol 2022;140.

The authors provided this information as a supplement to their article.

Appendix 1. ICD-9 and ICD-10 Codes Used for Data Extraction

Diagnosis ICD-9 ICD-10

Hypertension 401, 402, 403, 404, 405

I10, I11.0, I11.9, I12.0, I 12.9, I13.0, I13.10, I 13.11, I13.2, I15.0, I15.1, I15.2, I15.8, I15.9

Stroke 434.91, 437.00, 437.10 I63.9, I67.2, I67.9 Thromboembolism 437.6, 453, 671.5, 671.9 I82

Cardiomyopathy 425.4 I42.9

Renal Failure 586 N18, N19

Arrhythmia 427.31, 427.9 I48.91, I149.9

Peripheral Vascular Disease

433.9 I73.9

Aortic Aneurysm 441.9 I81

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Coronary Artery Disease

414, 440.9, 414.00, 414.4, 414.3, 414.01, 414.06

I25.10

Retinopathy 362.11 H35.033

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Appendix 2. Outcomes by Obesity Status

Obesity (n=395) No Obesity (n=185)

Variable^† N Rate and 95% CI N Rate and 95% CI

Primary composite outcome (includes 1 or more of the 7 items below)

150 38.0% (33.2%-42.8%) 66 35.7% (28.8%-42.6%)

Severe cHTN by BP criteria 146 37.0% (32.2%-41.7%) 64 34.6% (27.7%-41.5%)

Any stroke 1 0.3% (0.01%-1.4%) 1 0.5% (0.01%-3.0%)

DVT† 5 1.3% (0.4%-2.9% 1 0.5% (0.01%-3.0%)

Heart Failure 3 0.8% (0.2%-2.2%) 0 -

Maternal death 4 1.0% (0.3%-2.6%) 2 1.1% (0.1%-3.9%)

Renal failure (serum creatinine >1.1) 0 - 1 0.5% (0.01%-3.0%)

Other uncategorized Cardiovascular disease 1 0.3% (0.01%-1.4%) 0 -

Secondary outcomes ‡

Arrhythmia 1 0.3% (0.01%-1.4%) 0

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Atrial fibrillation or flutter 2 0.5% (0.06%-1.8%) 0

Carotid stenosis 0 - 1 0.5% (0.01%-3.0%)

Perinatal death 9 2.3% (1.1%-4.3%) 6 3.2% (1.2%-6.9%)

†67 missing values; 20 in outcome group and 47 in non-outcome group

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Appendix 3. Characteristics by Race and Ethnicity

Black White Hispanic,

Asian, Pacific Islander

Variable Patients

with Primary Outcome n = 183

Patients without Primary Outcome n = 243

Patients with Primary Outcome n = 44

Patients without Primary Outcome n = 128

Patients with Primary Outcome n = 9

Patients without Primary Outcome n = 39 Years of Age, mean ± SD 29.5±5.7 28.8±5.7 30.8±6.1 30.6±5.8 31.9±6.7 31.4±5.5 BMI (kg/m²), mean ± SD† 36.5±10.7 36.4±10.4 33.9±7.3 33.0±10.7 37.1±9.3 33.9±8.4 Obese at 1^stPNV (BMI ≥ 30 kg/m2), n

(%)†

117 (69.2%) 164 (74.6%) 26 (68.4%) 56 (50.1%) 7 (77.8%) 24 (72.7%)

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Nulliparous, n (%)‡ 46 (25.3%) 72 (29.8%) 12 (27.3%) 55 (43.0%) 1 (11.1%) 5 (12.8%) GDM, n (%) 23 (12.6%) 23 (9.5%) 4 (9.1%) 16 (12.5%) 2 (22.2%) 8 (20.5%) Current or Former Smoker, n (%) 84 (45.9%) 81 (33.3%) 27 (61.4%) 55 (43.0%) 1 (11.1%) 7 (18.0%)

Any Drug Use, n (%) 28 (15.3%) 29 (11.9%) 4 (9.1%) 13 (10.2%) - -

Preeclampsia 32 (17.5%) 41 (16.9%) 6 (13.6%) 27 (21.1%) 1 (11.1%) 8 (20.5%) PTB <37 weeks 64 (35.0%) 79 (32.5%) 12 (27.3%) 37 (28.9%) 4 (44.4) 9 (23.1%)

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Appendix 4. Adjusted Odds Ratios

Primary characteristic Adjusted aOR (95% CI)

Preeclampsia 0.85 (0.55 – 1.32)

Race/Ethnicity

Black or African American Hispanic/Latina/Other White

2.33 (1.56 – 3.47) 0.80 (0.36 – 1.81) - referent -

Current or former smoker 1.74 (1.24 – 2.44)

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Appendix 5. Adjusted and Unadjusted Hazard Ratios

Primary characteristic Unadjusted HR (95% CI) Adjusted HR (95% CI)

Preeclampsia at baseline 0.93 (0.66 – 1.31) 0.93 (0.66 – 1.32)

Race/Ethnicity Black or African American

Hispanic/Latina/Other White

1.93 (1.39 – 2.69) 0.71 (0.34 – 1.45) - referent -

1.99 (1.43 – 2.76) 0.79 (0.39 – 1.34) - referent -

Current or former smoker 1.48 (1.14 – 1.91) 1.47 (1.13 – 1.90)

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Appendix 6. Mean Times to Event in the Three Groups

Race or Ethnicity Mean +/- std deviation Median (Q1-Q3)

Black 5.0 +/- 0.1 7.1 (2.2-7.3)

White 6.0 +/- 0.2 7.0 (7.0-7.2)

Hispanic or None of the above

5.5 +/- 0.2 N/A