Appendix Table 1. Overall myocardial infarction incidence rate (events per 1000 patients-year) across all analyzed studies.
Rate mean 95% Conf. Interval
overall (18 studies) 3.026 1.889 4.845
ABC 2.463 1.387 4.372
Controls 3.347 1.617 6.925
IRR ABC vs controls 0.735964 0.303847 1.782617 NS
Abbreviations: ‘‘Overall’’ is the overall incidence ratio of myocardial infarction (MI) across all studies, irrespective of the drugs used for treatment;
‘‘ABC’’ is the incidence ratio of M.I. across all studies in the arms treated with ABC; ‘‘controls’’ is the incidence ratio of M.I. across all studies in the arms treated with a treatment not including ABC. IRR (incidence rate ratio) is not significantly (NS) different from 1 (null hypothesis).
Appendix Fig. 1. Methodological quality graph: review authors’ judgements about each methodological quality item presented as percentages across all included studies. The assessment is based on the primary outcomes of included trials.
Appendix Fig. 2. Methodological quality summary: review authors’ judgements about each methodological quality item for each included study. The assessment is based on the primary outcomes of included trials. for 34 reports, corresponding to 28 primary trials, but not for the meta-analysis of BICOMBO and STEAL data [40].
Appendix. Fig. 3. Forest plot of comparison: Abacavir vs controls, outcome: Myocardial Infarction. Subgroup analysis of studies in experienced patients.
Appendix Fig. 4. Forest plot of comparison: Abacavir vs controls, outcome: Myocardial Infarction. Subgroup analysis of studies in naives.
Appendix Fig. 5. Forest plot of comparison: Abacavir vs controls, outcome: Myocardial Infarction. Subgroup analysis of studies after exclusion of studies with PIs in the comparator group but not in ABC group.
Appendix Fig. 6. Forest plot of comparison: Abacavir vs controls, outcome: Myocardial Infarction. Subgroup analysis of studies in experienced patients after exclusion of studies with PIs in the comparator group but not in ABC group.
Appendix Fig. 7. Forest plot of comparison: Abacavir vs controls, outcome:Overall Major Cardiovascular events.
Subgroup analysis of studies in experienced patients.
