Appendix 1. Systematic Literature Search - http;//links.lww.com

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Liang AL, Gingher EL, Coleman JS. Medical cannabis for gynecologic pain conditions: a systematic review. Obstet Gynecol 2022;139.

The authors provided this information as a supplement to their article.

Appendix 1. Systematic Literature Search Total number of results: 5,189

Number after removal of duplicates: 3,997 Number of duplicates removed: 1,192

PubMed

1,614 results May032021

("Female"[Mesh] OR "Women"[Mesh] OR woman[tw] OR womans[tw] OR woman’s[tw] OR women[tw]

OR womens[tw] OR women’s[tw] OR female[tw] OR females[tw] OR feminine[tw])

AND ("Cannabis"[Mesh] OR "Cannabinoids"[Mesh] OR "Medical Marijuana"[Mesh] OR cannabi*[tw] OR endocannabi*[tw] OR marijuana*[tw] OR marihuana*[tw] OR hemp[tw] OR hemps[tw] OR hashish*[tw]

OR bhang*[tw] OR ganja*[tw] OR "Endocannabinoids"[Mesh] OR "Marijuana Use"[Mesh] OR THC[tw]

OR THCs[tw] OR CBD[tw] OR CBDs[tw] OR dexanabinol[tw] OR dextronantradol[tw] OR dronabinol[tw]

OR endocannabi*[tw] OR lenabasum[tw] OR levonantradol[tw] OR methanandamide[tw] OR "n

oleoylethanolamine"[tw] OR nabiximols[tw] OR nantradol[tw] OR "noladin ether"[tw] OR palmidrol[tw]

OR tetrahydrocannabi*[tw] OR virodhamine[tw] OR anandamide[tw] OR deacetyllevonantradol[tw] OR phytocannabi*[tw] OR arachidonoylethanolamine[tw] OR carboxytetrahydrocannabi*[tw] OR

impulsin[tw] OR palmitamide[tw] OR palmitoylethanolamine[tw] OR palmitoylethanolamide[tw] OR

“nantradol hydrochloride”[tw] OR sativex[tw] OR ethanolamine[tw] OR “n oleoyl”[tw] OR

oleoylethanolamide[tw] OR ethanesulfonamide[tw] OR propylamide[tw] OR eicosatetraenamide[tw] OR

“levo nantradol”[tw] OR levonantradol[tw] OR “ajulemic acid”[tw] OR anabasum[tw] OR resunab[tw] OR endocannabi*[tw] OR “dextro nantradol”[tw] OR “deacetyl levonantradol”[tw] OR eucannabi*[tw] OR charas[tw] OR “benzamide maleate”[tw] OR cardiolrx[tw] OR epidiolex[tw] OR epidyolex[tw] OR nabidiolex[tw] OR arachidonoylethanolamide[tw] OR arachidonylethanolamide[tw] OR

arachidonamide[tw] OR arachidonoylethanolamine[tw] OR “methylcannabi*”[tw] OR dimethylcannabi*[tw] OR “naphthalenyl methanone”[tw] OR “hydroxy dronabinol”[tw] OR arachidonylglycerol[tw] OR “arachidonate glycerol”[tw] OR naphthalenylmethanone[tw]) AND

("Pain"[Mesh:NoExp] OR "Abdominal Pain"[Mesh] OR "Back Pain"[Mesh] OR "Breakthrough Pain"[Mesh]

OR "Cancer Pain"[Mesh] OR "Chronic Pain"[Mesh] OR "Flank Pain"[Mesh] OR "Low Back Pain"[Mesh] OR

"Musculoskeletal Pain"[Mesh] OR "Myalgia"[Mesh] OR "Neuralgia"[Mesh:NoExp] OR "Nociceptive Pain"[Mesh] OR "Piriformis Muscle Syndrome"[Mesh] OR "Pudendal Neuralgia"[Mesh] OR

"Sciatica"[Mesh] OR "Pain, Intractable"[Mesh] OR "Pain, Referred"[Mesh] OR "Pelvic Girdle Pain"[Mesh]

OR "Pelvic Pain"[Mesh] OR "Visceral Pain"[Mesh] OR cystalgia*[tw] OR "Pudendal Neuralgia"[tw] OR

"Sciatica"[tw] OR myalgia*[tw] OR neuralgia*[tw] OR "Piriformis Syndrome"[tw] OR "Piriformis Muscle Syndrome"[tw] OR backache*[tw] OR "back ache*"[tw] OR sciatic[tw] OR "Pain Management"[Mesh] OR

"Pain Measurement"[Mesh] OR "Pain Clinics"[Mesh] OR "Analgesia"[Mesh] OR pain[tw] OR pains[tw] OR painful*[tw] OR "nociception test*"[tw] OR "Formalin test*"[tw] OR analgesia*[tw] OR analgesic*[tw]

OR anodyne*[tw] OR analgetic*[tw] OR "Dysmenorrhea"[Mesh] OR "Endometriosis"[Mesh] OR

“Adenomyosis”[Mesh] OR "Vagina"[Mesh] OR "Women's Health"[Mesh] OR "Women's Health

Services"[Mesh] OR "Pelvic Floor Disorders"[Mesh] OR "Pelvic Floor"[Mesh] OR “pelvis floor muscle”[tw]

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OR dyspareunia[tw] OR "Women's Health"[tw] OR "Womens Health"[tw] OR "Women Health"[tw] OR

"Woman's Health"[tw] OR "Womans Health"[tw] OR "Woman Health"[tw] OR "Vulvodynia"[Mesh] OR

"Dyspareunia"[Mesh] OR "Adenomyosis"[tw] OR cystalgia[tw] OR dysmenorrhea*[tw] OR

endometrioma*[tw] OR endometrios*[tw] OR "pelvic diaphragm*"[tw] OR "pelvic floor*"[tw] OR "pelvic floor disorder"[tw] OR "pelvic floor disorders"[tw] OR "pelvic floor dysfunction"[tw] OR "pelvis

floor*"[tw] OR vulvodynia*[tw] OR "Vulvovaginal"[tw] OR "Vaginismus"[tw] OR "vulva"[tw] OR vagina*[tw] OR Uterus[tw] OR uterine[tw] OR uteri[tw] OR "Dysmenorrhea"[Mesh] OR "Vulva"[Mesh]

OR "Uterus"[Mesh] OR "Cystitis, Interstitial"[Mesh] OR “interstitial cyst*”[tw]) NOT ("Animals"[Mesh] NOT "Humans"[Mesh])

AND (English[lang]) AND (1990/01/01:2021/12/31[dp]) NOT ("Case Reports" [Publication Type])

Embase

2,833 results May032021 ('female'/exp

OR woman:ti,ab,kw OR womans:ti,ab,kw OR woman$s:ti,ab,kw OR women:ti,ab,kw OR womens:ti,ab,kw OR women$s:ti,ab,kw OR female:ti,ab,kw OR females:ti,ab,kw OR feminine:ti,ab,kw)

AND

('cannabinoid'/exp OR 'cannabis'/exp OR 'medical cannabis'/exp

OR cannabi*:ti,ab,kw OR endocannabi*:ti,ab,kw OR marijuana*:ti,ab,kw OR

marihuana*:ti,ab,kw OR hemp:ti,ab,kw OR hemps:ti,ab,kw OR hashish*:ti,ab,kw OR bhang*:ti,ab,kw OR ganja*:ti,ab,kw OR 'endocannabinoid'/exp OR 'cannabis use'/exp OR THC:ti,ab,kw OR THCs:ti,ab,kw OR CBD:ti,ab,kw OR CBDs:ti,ab,kw

OR dexanabinol:ti,ab,kw OR dextronantradol:ti,ab,kw OR dronabinol:ti,ab,kw OR endocannabi*:ti,ab,kw OR lenabasum:ti,ab,kw OR levonantradol:ti,ab,kw OR methanandamide:ti,ab,kw OR

"n oleoylethanolamine":ti,ab,kw OR nabiximols:ti,ab,kw OR nantradol:ti,ab,kw OR

"noladin ether":ti,ab,kw OR palmidrol:ti,ab,kw OR tetrahydrocannabi*:ti,ab,kw OR virodhamine:ti,ab,kw OR anandamide:ti,ab,kw OR deacetyllevonantradol:ti,ab,kw OR phytocannabi*:ti,ab,kw OR arachidonoy lethanolamine:ti,ab,kw OR carboxytetrahydrocannabi*:ti,ab,kw OR impulsin:ti,ab,kw OR palmitamide:ti, ab,kw OR palmitoylethanolamine:ti,ab,kw OR palmitoylethanolamide:ti,ab,kw OR “nantradol

hydrochloride”:ti,ab,kw OR sativex:ti,ab,kw OR ethanolamine:ti,ab,kw OR “n

oleoyl”:ti,ab,kw OR oleoylethanolamide:ti,ab,kw OR ethanesulfonamide:ti,ab,kw OR propylamide:ti,ab,k w OR eicosatetraenamide:ti,ab,kw OR “levo nantradol”:ti,ab,kw OR levonantradol:ti,ab,kw OR

“ajulemic acid”:ti,ab,kw OR anabasum:ti,ab,kw OR resunab:ti,ab,kw OR endocannabi*:ti,ab,kw OR

“dextro nantradol”:ti,ab,kw OR “deacetyl

levonantradol”:ti,ab,kw OR eucannabi*:ti,ab,kw OR charas:ti,ab,kw OR “benzamide

maleate”:ti,ab,kw OR cardiolrx:ti,ab,kw OR epidiolex:ti,ab,kw OR epidyolex:ti,ab,kw OR nabidiolex:ti,ab,k w OR arachidonoylethanolamide:ti,ab,kw OR arachidonylethanolamide:ti,ab,kw OR arachidonamide:ti,a b,kw OR arachidonoylethanolamine:ti,ab,kw OR

“methylcannabi*”:ti,ab,kw OR dimethylcannabi*:ti,ab,kw OR “naphthalenyl methanone”:ti,ab,kw OR

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“hydroxy dronabinol”:ti,ab,kw OR arachidonylglycerol:ti,ab,kw OR “arachidonate glycerol”:ti,ab,kw OR naphthalenylmethanone:ti,ab,kw)

AND ('pain'/de OR 'abdominal pain'/exp OR 'backache'/de OR 'breakthrough pain'/exp OR 'cancer pain'/exp OR 'chronic pain'/exp OR 'cystalgia'/exp OR 'flank pain'/exp OR 'low back pain'/exp OR 'musculoskeletal pain'/exp OR 'myalgia'/de OR 'neuralgia'/de OR 'neuropathic pain'/exp OR 'nociceptive pain'/exp OR 'piriformis syndrome'/exp OR 'pudendal neuralgia'/exp OR 'sciatica'/exp OR 'intractable pain'/exp OR 'referred pain'/exp OR 'pelvic pain'/exp OR 'pelvic girdle pain'/exp OR 'visceral pain'/exp

OR cystalgia*:ti,ab,kw OR "Pudendal Neuralgia":ti,ab,kw OR "Sciatica":ti,ab,kw OR myalgia*:ti,ab,kw OR neuralgia*:ti,ab,kw OR "Piriformis Syndrome":ti,ab,kw OR "Piriformis Muscle Syndrome":ti,ab,kw OR backache:ti,ab,kw OR "back ache*":ti,ab,kw OR sciatic:ti,ab,kw OR 'analgesia'/exp OR 'pain

assessment'/exp OR 'pain measurement'/exp OR 'pain clinic'/exp OR pain:ti,ab,kw OR pains:ti,ab,kw OR painful*:ti,ab,kw OR "nociception test*":ti,ab,kw OR "Formalin test*":ti,ab,kw OR

analgesia*:ti,ab,kw OR analgesic*:ti,ab,kw OR anodyne*:ti,ab,kw OR analgetic*:ti,ab,kw OR 'adenomyosis'/exp OR 'cystalgia'/exp OR 'dysmenorrhea'/exp OR 'dyspareunia'/exp OR 'endometriosis'/exp OR 'interstitial cystitis'/exp OR 'pelvic floor disorder'/exp OR 'pelvic floor prolapse'/exp OR 'pelvis floor'/exp OR 'pelvis floor muscle'/exp OR 'uterus'/exp OR 'vagina'/exp OR 'vulva'/exp OR 'vulvodynia'/exp OR 'women`s health'/exp OR "adenomyosis":ti,ab,kw OR

'cystalgia':ti,ab,kw OR dysmenorrhea*:ti,ab,kw OR "dyspareunia":ti,ab,kw OR endometrioma*:ti,ab,kw OR endometrios*:ti,ab,kw OR 'interstitial cyst*':ti,ab,kw OR "pelvic diaphragm*":ti,ab,kw OR "pelvic floor*":ti,ab,kw OR "pelvic floor disorder":ti,ab,kw OR "pelvic floor disorders":ti,ab,kw OR "pelvic floor dysfunction":ti,ab,kw OR "pelvis floor*":ti,ab,kw OR uterine:ti,ab,kw OR uteri:ti,ab,kw OR

uterus:ti,ab,kw OR vagina*:ti,ab,kw OR "vaginismus":ti,ab,kw OR "vulva":ti,ab,kw OR vulvodynia*:ti,ab,kw OR "Vulvovaginal":ti,ab,kw OR (woman NEXT/2 health):ti,ab,kw OR 'womans health':ti,ab,kw OR 'woman health':ti,ab,kw OR (women NEXT/2 health):ti,ab,kw OR 'womens health':ti,ab,kw OR 'women health':ti,ab,kw)

NOT ('animal'/exp NOT 'human'/exp) AND ([english]/lim) AND ([1990-2021]/py)

NOT ('case report'/exp OR 'conference paper'/exp OR 'conference abstract'/exp OR 'conference review'/exp)

Scopus

81 results May032021 limited to English and from 1990-present and with removal of records indexed for Medline and Embase – which should be captured by PubMed and Embase

TIT-ABS-KEY(woman OR womans OR woman’s OR women OR womens OR women’s OR female OR females OR feminine)

AND TIT-ABS-KEY(cannabi* OR endocannabi* OR marijuana* OR marihuana* OR hemp OR hemps OR hashish* OR bhang* OR ganja* OR THC OR THCs OR CBD OR CBDs OR dexanabinol OR dextronantradol OR dronabinol OR endocannabi* OR lenabasum OR levonantradol OR methanandamide OR "n

oleoylethanolamine" OR nabiximols OR nantradol OR "noladin ether" OR palmidrol OR

(4)

tetrahydrocannabi* OR virodhamine OR anandamide OR deacetyllevonantradol OR phytocannabi* OR arachidonoylethanolamine OR carboxytetrahydrocannabi* OR impulsin OR palmitamide OR

palmitoylethanolamine OR palmitoylethanolamide OR "nantradol hydrochloride" OR sativex OR ethanolamine OR "n oleoyl" OR oleoylethanolamide OR ethanesulfonamide OR propylamide OR

eicosatetraenamide OR "levo nantradol" OR levonantradol OR "ajulemic acid" OR anabasum OR resunab OR endocannabi* OR "dextro nantradol" OR "deacetyl levonantradol" OR eucannabi* OR charas OR

"benzamide maleate" OR cardiolrx OR epidiolex OR epidyolex OR nabidiolex OR arachidonoylethanolamide OR arachidonylethanolamide OR arachidonamide OR

arachidonoylethanolamine OR methylcannabi* OR dimethylcannabi* OR "naphthalenyl methanone" OR

"hydroxy dronabinol" OR arachidonylglycerol OR "arachidonate glycerol" OR naphthalenylmethanone) AND

TIT-ABS-KEY(cystalgia* OR "Pudendal Neuralgia" OR "Sciatica" OR myalgia* OR neuralgia* OR "Piriformis Syndrome" OR "Piriformis Muscle Syndrome" OR backache* OR "back ache*" OR sciatic OR pain OR pains OR painful* OR "nociception test*" OR "Formalin test*" OR analgesia* OR analgesic* OR anodyne*

OR analgetic* OR "pelvis floor muscle" OR dyspareunia OR "Women's Health" OR "Womens Health" OR

"Women Health" OR "Woman's Health" OR "Womans Health" OR "Woman Health" OR adenomyosis OR dysmenorrhea* OR endometrioma* OR endometrios* OR "pelvic diaphragm*" OR "pelvic floor*" OR

"pelvic floor disorder" OR "pelvic floor disorders" OR "pelvic floor dysfunction" OR "pelvis floor*" OR vulvodynia* OR "Vulvovaginal" OR "Vaginismus" OR "vulva" OR vagina* OR Uterus OR uterine OR uteri OR "interstitial cyst*")

AND NOT

(INDEX(medline) OR INDEX(embase))

Cochrane

Search run May032021:

103 reviews 9 Protocols 490 trials

([mh "Female"] OR [mh "Women"] OR woman OR womans OR woman’s OR women OR womens OR women’s OR female OR females OR feminine)

AND ([mh "Cannabis"] OR [mh "Cannabinoids"] OR [mh "Medical Marijuana"] OR cannabi* OR endocannabi*

OR marijuana* OR marihuana* OR hemp OR hemps OR hashish* OR bhang* OR ganja* OR [mh

"Endocannabinoids"] OR [mh "Marijuana Use"] OR THC OR THCs OR CBD OR CBDs OR dexanabinol OR dextronantradol OR dronabinol OR endocannabi* OR lenabasum OR levonantradol OR methanandamide OR "n oleoylethanolamine" OR nabiximols OR nantradol OR "noladin ether" OR palmidrol OR

tetrahydrocannabi* OR virodhamine OR anandamide OR deacetyllevonantradol OR phytocannabi* OR arachidonoylethanolamine OR carboxytetrahydrocannabi* OR impulsin OR palmitamide OR

palmitoylethanolamine OR palmitoylethanolamide OR "nantradol hydrochloride" OR sativex OR ethanolamine OR "n oleoyl" OR oleoylethanolamide OR ethanesulfonamide OR propylamide OR

(5)

eicosatetraenamide OR "levo nantradol" OR levonantradol OR "ajulemic acid" OR anabasum OR resunab OR endocannabi* OR "dextro nantradol" OR "deacetyl levonantradol" OR eucannabi* OR charas OR

"benzamide maleate" OR cardiolrx OR epidiolex OR epidyolex OR nabidiolex OR arachidonoylethanolamide OR arachidonylethanolamide OR arachidonamide OR

arachidonoylethanolamine OR methylcannabi* OR dimethylcannabi* OR "naphthalenyl methanone" OR

"hydroxy dronabinol" OR arachidonylglycerol OR "arachidonate glycerol" OR naphthalenylmethanone) AND

([mh ^"Pain"] OR [mh "Abdominal Pain"] OR [mh "Back Pain"] OR [mh "Breakthrough Pain"] OR [mh

"Cancer Pain"] OR [mh "Chronic Pain"] OR [mh "Flank Pain"] OR [mh "Low Back Pain"] OR [mh

"Musculoskeletal Pain"] OR [mh "Myalgia"] OR [mh ^"Neuralgia"] OR [mh "Nociceptive Pain"] OR [mh

"Piriformis Muscle Syndrome"] OR [mh "Pudendal Neuralgia"] OR [mh "Sciatica"] OR [mh "Pain, Intractable"] OR [mh "Pain, Referred"] OR [mh "Pelvic Girdle Pain"] OR [mh "Pelvic Pain"] OR [mh

"Visceral Pain"] OR cystalgia* OR "Pudendal Neuralgia" OR "Sciatica" OR myalgia* OR neuralgia* OR

"Piriformis Syndrome" OR "Piriformis Muscle Syndrome" OR backache* OR (back NEXT/1 ache*) OR sciatic OR [mh "Pain Management"] OR [mh "Pain Measurement"] OR [mh "Pain Clinics"] OR [mh

"Analgesia"] OR pain OR pains OR painful* OR (nociception NEXT/1 test*) OR (Formalin NEXT/1 test*) OR analgesia* OR analgesic* OR anodyne* OR analgetic* OR [mh "Dysmenorrhea"] OR [mh

"Endometriosis"] OR [mh “Adenomyosis”] OR [mh "Vagina"] OR [mh "Women's Health"] OR [mh

"Women's Health Services"] OR [mh "Pelvic Floor Disorders"] OR [mh "Pelvic Floor"] OR "pelvis floor muscle" OR dyspareunia OR "Women's Health" OR "Womens Health" OR "Women Health" OR

"Woman's Health" OR "Womans Health" OR "Woman Health" OR [mh "Vulvodynia"] OR [mh

"Dyspareunia"] OR "adenomyosis" OR cystalgia OR dysmenorrhea* OR endometrioma* OR

endometrios* OR (pelvic NEXT/1 diaphragm*) OR (pelvic NEXT/1 floor*) OR "pelvic floor disorder" OR

"pelvic floor disorders" OR "pelvic floor dysfunction" OR (pelvis NEXT/1 floor*) OR vulvodynia* OR

"Vulvovaginal" OR "Vaginismus" OR "vulva" OR vagina* OR Uterus OR uterine OR uteri OR [mh

"Dysmenorrhea"] OR [mh "Vulva"] OR [mh "Uterus"] OR [mh "Cystitis, Interstitial"] OR (interstitial NEXT/1 cyst*))

Clinicaltrials.gov 59 results May032021

Condition: (woman OR womans OR woman’s OR women OR womens OR women’s OR female OR females OR feminine)

AND

Drug: (cannabis OR cannabinoid OR cannabinoids OR endocannabinoid OR endocannabinoids OR

marijuana OR marihuana OR hemp OR hashish OR bhang OR ganja OR THC OR THCs OR CBD OR CBDs OR dronabinol OR tetrahydrocannabinoid)