Appendix
Database: Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) <1948 to Present>
--- 1 *selenium/ or *selenium compounds/ or sodium selenite/ (13016) 2 limit 1 to (yr="1995 -Current" and randomized controlled trial) (251) 3 limit 2 to humans (204)
Database: Ovid EMBASE In-Process & Other Non-Indexed Citations and Ovid EMBASE <1948 to Present>
---
1 selenium/ or selenium compounds/ or sodium selenite/ or selenium.mp. (23183)
2 *critical illness/th or sepsis/ or shock, septic/ or systemic inflammatory response syndrome/
(57723)
3 1 and 2 (78)
4 limit 3 to (yr="1995 -Current" and randomized controlled trial) (18)
List of excluded full-text articles:
Pediatrics population 1,2 Different population 3,4 Different outcome 5-7 Other interventions 8,9 Observational study 10 Duplicate publication 11 Review article 12
1. Carcillo J, Holubkov R, Dean JM, et al. Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. JPEN Journal of parenteral and enteral nutrition 2009;33:368-74.
2. Darlow BA, Winterbourn CC, Inder TE, et al. The effect of selenium supplementation on outcome in very low birth weight infants: a randomized controlled trial. The New Zealand Neonatal Study Group. The Journal of pediatrics 2000;136:473-80.
3. Berger MM, Soguel L, Shenkin A, et al. Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and
subarachnoid hemorrhage patients. Crit Care 2008;12:R101.
4. Engel JM, Menges T, Neuhauser C, Schaefer B, Hempelmann G. [Effects of various feeding regimens in multiple trauma patients on septic complications and immune parameters].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 1997;32:234-9.
5. Angstwurm MW, Schopohl J, Gaertner R. Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients. European journal of endocrinology / European Federation of Endocrine Societies 2004;151:47-54.
6. Manzanares W, Biestro A, Galusso F, et al. High-dose selenium for critically ill patients with systemic inflammation: pharmacokinetics and pharmacodynamics of selenious acid: a pilot study. Nutrition 2010;26:634-40.
7. Lehmann C, Egerer K, Weber M, et al. [Effect of selenium administration on various laboratory parameters of patients at risk for sepsis syndrome]. Med Klin (Munich) 1997;92 Suppl 3:14-6.
8. Beale RJ, Sherry T, Lei K, et al. Early enteral supplementation with key
pharmaconutrients improves Sequential Organ Failure Assessment score in critically ill patients with sepsis: outcome of a randomized, controlled, double-blind trial. Critical care medicine 2008;36:131-44.
9. Bertolini G, Iapichino G, Radrizzani D, et al. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial.
Intensive care medicine 2003;29:834-40.
10. Forceville X, Vitoux D, Gauzit R, Combes A, Lahilaire P, Chappuis P. Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients. Critical care medicine 1998;26:1536-44.
11. Gartner R, Angstwurm MW, Schottdorf J. [Selenium administration in sepsis patients].
Med Klin (Munich) 1997;92 Suppl 3:12-4.
12. Forceville X. Effects of high doses of selenium, as sodium selenite, in septic shock patients a placebo-controlled, randomized, double-blind, multi-center phase II study--selenium and sepsis. J Trace Elem Med Biol 2007;21 Suppl 1:62-5.
