Association between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: a Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations
Qing-Qing Zhu, MD, Xin-Lin Zhang, MD,Si-Min Zhang, MM, Shao-Wen Tang, PhD, Hai-Yan Min, PhD, Long Yi, PhD, Biao Xu, MD, PhD, Yong Song, MD, PhD
Search strategy in PubMed:(“Idiopathic pulmonary fibrosis” or “IPF” or “Usual interstitial pneumonia” or “UIP” or “Cryptogenic FibrosingAlveolitis”
or “Hamman Rich Disease” or “Fibrocystic Pulmonary Dysplasia”) and (rs35705950 or (("MUC5B" or "mucin 5B" or "MG1" or "MUC5" or "MUC9" or
"MUC-5B") and ("polymorphism" or "mutation" or "variation")))
Association between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis: a Meta-analysis and Trial Sequential Analysis in Caucasian and Asian Populations
Qing-Qing Zhu, MD, Xin-Lin Zhang, MD,Si-Min Zhang, MM, Shao-Wen Tang, PhD, Hai-Yan Min, PhD, Long Yi, PhD, Biao Xu, MD, PhD, Yong Song, MD, PhD
Table S1.Quality assessment of studies using the Newcastle-Ottawa Scale (NOS), and the definitions of IPF patients and controls.
First author Year Ethnicity Selection Comparability Exposure Total IPF patients Controls
Seibold, et al 2011 Caucasian 4 1 3 8 The 2001 American Thoracic Society/European
Respiratory Society consensus (A high resolution computerized tomography (HRCT) scan was required to show definite or probable IIP according to predefined criteria, a surgical lung biopsy was obtained in 46% of affected subjects.)
A COPD case-control cross-sectional study, excluded self-reported or had a physician-diagnosis of idiopathic pulmonary fibrosis or another interstitial lung disease.
Borie, et al 2013 Caucasian 3 1 3 7 The 2001 American Thoracic Society/European
Respiratory Society consensus (either surgical biopsy or a characteristic CT scan pattern)
Healthy unrelated individuals who were ethnically matched.
Noth, et al 2013 Caucasian 4 1 3 8 The 2000 and 2011 guidelines from the American
Thoracic Society and European Respiratory Society (A high-resolution CT scan that showed definite or probable usual interstitial pneumonitis was necessary for inclusion. A surgical lung biopsy sample to confirm usual interstitial pneumonitis could be obtained if the diagnosis
Healthy individuals free of lung diseases based on ICD9 coding and medical record review.
was in doubt, a surgical lung biopsy was obtained in 37.3% of subjects)
Stock, et al 2013 Caucasian 4 2 3 9 The 2001 criteria of the American Thoracic
Society/European Respiratory Society
Healthy blood donors based on a self-administered questionnaire and by the routine laboratory investigations performed on blood donors.
Horimasu, et al 2014 Asian 4 1 3 8 The 2001 criteria of the American Thoracic
Society/European Respiratory Society
Healthy subjects underwent pulmonary function tests and chest X-ray studies, excluded those with apparent lung disease such as interstitial lung diseases (ILD) or chronic obstructive pulmonary disease.
Horimasu, et al 2014 Caucasian 4 1 3 8 The criteria of the American Thoracic
Society/European Respiratory Society in 2002
Healthy subjects underwent pulmonary function tests and chest X-ray studies, excluded those with apparent lung disease such as interstitial lung diseases (ILD) or chronic obstructive pulmonary disease.
Wang, et al 2014 Asian 4 2 3 9 The 2011 American Thoracic Society/European
Respiratory Society International Consensus, exclusion of the known causes of interstitial lung disease (clinical features and HRCT evaluation, and ahistopathologic diagnosis was made for the cases with an atypical HRCT image)
Healthy individuals who were undergoing a routine physical examination at the same hospital
Peljto, et al. 2015 Caucasian 3 2 3 8 The 2011 American Thoracic Society/European
Respiratory Society International Consensus Guidelines
NA
Peljto, et al. 2015 Asian 3 2 3 8 The 2011 American Thoracic Society/European Control subjects with at least 5 years of smoking
Respiratory Society International Consensus Guidelines
history (former and current) and normal pulmonary function tests were recruited from a smoking cessation program at the same institute, and nonsmoking control subjects were unrelated healthy volunteers.