We noticed an improvement in the thickness of the tissue and tenderness on the extremities. Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables predicting outcome.
Lymphatic impairment as a cause of ICD
We observed the development of hypertrophic scars and keloids four weeks after herpes zoster infection in a 28-year-old woman during pregnancy. A 66-year-old male patient with severe facial herpes zoster developed a specific cutaneous zosteriform lesion of his existing B-cell chronic lymphocytic leukemia 5 days after shingles remission [28].
Stretch marks as ICD’s
Injection sites, stings and bites as an ICD
Previous sites of radiotherapy as ICD’s
A 64-year-old female patient with a medical history of locally advanced breast cancer of her right breast treated with radiotherapy and adjuvant drug therapy with anastrozole, a non-selective aromatase inhibitor. This segmental erythema multiforme-like drug eruption by anastrozole represents another example of the concept of ICD [41].
Tattoos as ICD’s
Surgical scars as ICD’s
Burn scars as ICD’s
Squamous cell carcinoma, basal cell carcinoma, and, to a lesser extent, melanoma have been reported with a latency of one year to decades [60]. Vanhooteghem and Theate (2018) reported a 66-year-old male patient suffering from severe 3rd degree burns on his legs.
Chronic friction as an ICD
Epilation sites as an ICD
Conclusions
Assessment of natural skin function change in split-thickness skin grafts by noninvasive bioengineering methods. Specific disseminated cutaneous infiltrates of B-cell chronic lymphocytic leukemia - Wolf's isotopic response after herpes zoster infection.
Introduction
Scalp and neck tumors had a poor survival rate (1-year relative survival rate) compared to trunk tumors (75.3% 10-year survival rate). An analysis of 50 patients with cutaneous angiosarcomas of the head and neck from the Princess Margaret Cancer Centre, Toronto/Ontario, Canada, estimated a 5-year overall survival (OS) of 9% for scalp tumors and 26% for facial tumors.
Patients and Methods
Discussion
In conclusion, cutaneous angiosarcoma of the head and neck is a rare but aggressive vascular malignancy with a less favorable prognosis than its trunk or extremity counterparts. Surgery with curative intent is associated with prolonged survival in patients with cutaneous angiosarcoma of the scalp and face - a retrospective study of 38 untreated cases in the Japanese population.
Botulin Toxin Use in Scars/Keloids Treatment
Material and Methods
Results
Botulinum toxin type a inhibits connective tissue growth factor expression in fibroblasts derived from hypertrophic scar. Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report.
Dermal Pleomorphic Sarcoma of the Scalp – Report of Two Cases
Case Report
AFX and DPS are sarcomatous neoplasms of the head and neck region in elderly patients. Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas show a similar molecular phenotype.
Botulin Toxin Use in Rosacea and Facial Flushing Treatment
We analyzed published data on off-label applications of BTX for rosacea and facial flushing retrieved from PubMed. Single-arm pilot studies involving patients with facial flushing were performed and showed an improvement within a variable time ranging from 2 weeks to 3 months after a single treatment of a variable dose of BTX (from 1 to 2 IU/ cm while the only randomized controlled trial followed for 6 months with 60 patients with menopausal hot flashes treated with a single injection of 6.2 IU BTX per cm2 versus 0.9% saline and showed a reduction sensitive to the mean number of menopausal hot flashes after 2 months.
A Painful Step - Pendulating Plantar Eccrine Poroma
The foul odor was related to bacterial contamination of the lesion with Corynebacterium striatum, Streptococcus dysgalactiae, Staphylococcus aureus, Citrobacter koseri. In conclusion, eccrine poromas of the sole are not uncommon, but pendulous tumors are extremely rare.
Under electron microscope, a single crown monocyte appears to be in close contact with the surface of the adipocyte (Figure 4C). These monocytes appear to contain small droplets in the cytoplasm that are similar to the contents of the adipocyte.
Eruption of rosacea - After photodynamic therapy (PDT) for field cancer and a review on adverse events with PDT in. Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicenter, randomized, observer-blinded phase III study in.
Wells Syndrome – An Odyssey
In conclusion, EC or Wells syndrome is a rare disorder of the spectrum of eosinophilic skin diseases. Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant.
Large B - Cell Lymphoma of the Leg – Unfavourable Course with Rituximab/Bendamustin
Primary cutaneous diffuse large B-cell lymphoma, NOS and bone type: Clinical, morphological and prognostic differences. Primary cutaneous diffuse large B-cell lymphoma, bone type: clinicopathologic features and prognostic analysis in 60 cases.
Adult Measles – Case Reports of a Highly Contagious Disease
Case reports
In this case, encephalitis was ruled out by CSF analysis and brain MRI. Complete genome sequences of mumps and measles virus isolates from three states in the United States.
Unilateral Pseudo-Ainhum in Liver Cirrhosis
Case Presentation
Pseudo-ainhum is defined as any case of auto-amputation not associated with the classic spontaneous ainhum seen in Africans of unknown etiology. Pseudo-ainhum has been described secondary to congenital amniotic bands known as Streeter's syndrome [9] or keratoderma hereditarium mutilans (Vohwinkel) [10].
A Sheep in Wolf’s Clothing: Lobular Pyogenic Granuloma Masquerading Nodular Amelanotic Melanoma
This group attempted to define typical dermoscopic patterns for pyogenic granuloma and its differential diagnosis. Pyogenic granuloma - a common benign vascular tumor with variable clinical presentation: new findings and treatment options.
Treatment of Psoriasis: Novel Approaches to Topical Delivery
In recent years, several technologies have been developed to increase the efficacy and safety of local drug therapy. For these purposes, vesicular drug delivery systems including niosomes, proniosomes, liposomes and transferosomes, non-vesicular drug delivery systems such as foams, gels and nanoparticles have been developed [6].
Ablative Fractional Lasers
Foams
Nanofibres
In a mouse model of psoriasis-like dermatitis induced by imiquimod, curcumin deposition was increased 2-fold compared to films lacking the lipid component.
Nanoparticles and Nano Emulsions
The 1⋅2 Br carrier material allowed a high level of drug release and did not limit penetration of the drug into human skin as measured by Franz cells. The gel also promotes retention of the drug in the skin twice (betamethasone) and 20 times (triamcinolone) more than the commercial formulations.
Ethosomes
Supratherapeutic amounts of CsA were delivered to human skin (μg cm-2) after application of a formulation with 1.67 mg/ml CsA and 5 mg/ml copolymer for only 1 h without transdermal permeation. Topical application of etanercept-loaded tNGs to human skin equivalents prepared from primary human keratinocytes and fibroblasts and treated with TNFα or tape-lined human skin resulted in ineffective drug delivery through the stratum corneum and into the vital epidermis.
Niosomes
Preparation, characterization and in vivo evaluation of cyclosporine cationic liposomes for the treatment of psoriasis. Polymeric micelle nanocarriers for the cutaneous delivery of tacrolimus: a targeted approach for the treatment of psoriasis.
Multiple Cutaneous Leiomyomas with Uterus Myomatosus (MCUL) – Two Case Reports and One New Mutation of FH Gene
Case Reports
She was screened by diagnostic ultrasound, abdominal magnetic resonance imaging and chest X-ray. Women with HLRCC tend to also develop multiple leiomyomas of the uterus, leading to uterine myomatosis.
Acknowledgements
Inactivation of fumarate hydratase in hereditary leiomyomatosis and renal cell carcinoma is synthetic lethal by induction of ferroptosis. Novel fumarate hydratase mutation in siblings with early-onset uterine leiomyoma and hereditary leiomyomatosis and renal cell carcinoma syndrome.
Nonmelanoma Skin Cancer with Skull Infiltration and Cranial Involvement
MRI suggested tumoral infiltration of the sagittal sinus and dura mater (Figure 1, C and D). We observed cauliflower-like exophytic growths with partial necrosis and discharges measuring 23 cm x 12 cm x 2.4 cm located in the midline of the frontal skull (Figure 3A).
Gut Microbiota and the Alteration of Immune Balance in Skin Diseases: From Nutraceuticals to Fecal Transplantation
Gut microbiota and immune dysregulation in skin diseases: from dietary supplements to fecal transplantation. The well-known gut-brain axis and gut-skin axis can be combined into a larger network - the gut-brain-skin axis, with complex regulation by cytokines, neuropeptides, neurohormones and other transmitter (signaling) molecules and perhaps the most important modulator of the gut-brain axis - skin/gut microbiota.
Gut microbiota
The SKA of low-dose signaling molecules activates some units of cellular (or plasmatic) receptors due to their low concentration. The availability of a Low Dose SKA signaling molecule is the key point of LDM.
Erythema Elevatum Diutinum - Two Case Reports, Two Different Clinical Presentations, and a Short Literature Review
We report on EED with two different clinical patterns – A) the classic nodules and plaques overlying the joints of upper limbs and B) scattered papules on legs and arms. A Case of Erythema Elevatum Diutinum With Pancytopenia: Focus on Dapsone-Induced Hematologic Side Effects and Colchicine as a Safe Treatment Option.
Psychological Impact of Melanoma, How to Detect, Support and Help
The most frequent psychological disorders and scales
The long-term quality of life of melanoma survivors is comparable to that of the general population. An immunotherapy survivor population: quality of life and health-related toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors.
Dermatoporosis – The Chronic Cutaneous Fragility Syndrome
Dermatoporosis
A French study conducted on a representative sample of the population (n = 533): Here, the overall prevalence of dermatoporosis was estimated to be 37.5% in subjects over 65 years of age, with a female predominance [5].
Aetiology
Bateman purpura
Complications of dermatoporosis
Deep dissecting hematoma
Dermatoporosis in the Intensive Care Unit (ICU)
Prevention and treatment of dermatoporosis
Skin Tears: State of the Science: Consensus Statements for the Prevention, Prediction, Assessment, and Treatment of Skin Tears©. Chronic fragility of the skin due to aging: current concepts in the pathogenesis, recognition and treatment of dermatoporosis.
Melanoma and Mastocytosis
Both mast cells and melanocytes require growth binding of stem cell factor (SCF) to the KIT receptor. The expression of melanoma inhibitory activity on mast cells in pediatric patients with cutaneous mastocytosis.
Clinical Applications of System Regulation Medicine
However, this method does not offer a solution in the non-manifest preclinical stage of the disease, when it would still be possible to reverse the pathological progression, correcting the underlying causes. Based on an accurate assessment of the patient's clinical history, recognition of his specific characteristics and the stage of the pathology's progress, BRSM directs the choices of the therapeutic strategy, allowing a more complete and systematic approach to the patient.
Systems Medicine
According to this most current reference model, at the diagnostic stage we tend to recognize dynamic patterns in network dysregulations instead of using isolated and unchanging biomarkers over time and, in particular, in the approach to the progressive evolution of the pathology, such models contribute to defining an individualized vision for each patient. In summary, System Medicine considers disease as a dysregulation of biological networks that changes during the evolution of the pathological process and with the development of comorbidities.
Systems Bioregulation Medicine
The inflammatory response of the organism and its effects on it in the acute phase play a fundamental role in the model of BrSM. Among the main protagonists is PGE2, which is not only responsible for most of the symptoms associated with acute inflammation, but also plays a fundamental role in the activation of so-called mediators favoring the resolution of the inflammatory process [26], [27. ].
Individualised treatments
Persistent inflammations can cause changes in the cellular microenvironment and progressively lead to tissue structural damage, up to their degeneration [45], [49]. Linearly developed drugs, such as non-steroidal anti-inflammatory drugs, whose main target is cyclo-oxygenase 2, have an anti-inflammatory action, but at the same time can prevent the resolution of the problem by strongly suppressing PGE2 [28].
Change in therapy paradigm
Low dose drugs effects
Synergistic treatments
34;Space - sensitive" treatments
A double-blind, randomized, saline-controlled trial of the efficacy and safety of concurrently administered intra-articular injections of Tr14 and Ze14 for the treatment of painful osteoarthritis of the knee: the MOZArT study. Novel organ representation areas located between the front and back of the human neck and body, their potential application to metamere.
Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review
Giant squamous cell carcinoma on chronic lichen planus on the ankle - A case report and brief literature review. Histological examination revealed a well-differentiated cutaneous squamous cell carcinoma (SCC), partially ulcerated, with bacterial colonization (Figure 3) on a verrucous lichen planus on the left leg and partially verrucous lichen planus on the right leg and left forearm (Figure 4) ).
The Impact of Immunological Factors on Depression Treatment – Relation Between Antidepressants and Immunomodulation
The research done so far has shown that innate immunity is mostly involved in the pathophysiology of depressive disorder, that is the activity of pro-inflammatory cytokines. Already mentioned pro-inflammatory cytokines activate pro-inflammatory prostaglandin E2 (PGE2), which plays a leading role in mediating inflammation [1].
Role of anti-inflammatory agents as antidepressants
Pro-inflammatory cytokines can be the future in the establishment of more successful antidepressant therapy, because they can be the target of anti-inflammatory therapy and modifiers of cytokine signals, in terms of defined biomarkers [3]. They can reduce the level of pro-inflammatory cytokines, while increasing anti-inflammatory cytokine levels that also contribute to reducing depressive symptoms [7].
Cytokine inhibitors
It has been shown that in a group of treatment-resistant depressed patients, those with higher levels of pro-inflammatory cytokines respond better to cytokine antagonists, compared to placebo. Targeting the pro-inflammatory cytokine IL-6 with the human monoclonal antibody Sirucumab may be the potential therapeutic approach in depressed patients.
Non-steroidal anti-inflammatory drugs
Sirukumab is a safe and tolerable drug that can modify the immune response in the healthy population as well as in patients with inflammatory diseases such as rheumatoid arthritis. Some other research has shown that NSAIDs in general, as well as paracetamol, inhibit the antidepressant effect of citalopram (both in animal and human experiments), unlike ASA and COX-2 inhibitors.
The other anti-inflammatory drugs and potential antidepressant agents
The reduction of inflammatory mediators during stressful procedures, or in any possible physiological or biochemical mechanism, may represent the possible antidepressant effect of Aspirin [18]. This discrepancy is a result of the different effects of NSAIDs, COX-2 inhibitors and salicylates on the antidepressant effect.
Immunomodulating effect of antidepressants
The anti-inflammatory effect of antidepressants may be the reason for the wide indications of their use [22]. Few studies are investigating the immunomodulatory effect of SSRIs, SNRIs and monoamine oxidase inhibitors (MAOIs) [29].
Conclusion
Regarding tricyclic antidepressants, there are also a few studies investigating their influence on innate and acquired immunity, but it is generally accepted that they have anti-inflammatory effects, especially by reducing Antidepressant and anti-inflammatory drugs differentially reduce the release of NGF and BDNF from rat platelets.
We report on erbium-doped yttrium aluminum garnet (erbium-YAG) laser therapy of familial chronic pemphigus.
Case report
Store-independent coupling between the Secretory Pathway Ca2+ transporting ATPase SPCA1 and Orai1 in Golgi stress and Hailey-Hailey disease. Laser therapy for the treatment of Hailey-Hailey disease: a systematic review focusing on carbon dioxide laser resurfacing.
A Black Hole at the Center of Earth Plays the Role of the Biggest System of Telecommunication for Connecting DNAs, Dark DNAs
We show that the earth's black DNA brane is the largest telecommunication system that exchanges waves with all DNA and water molecules. In section III we show that the earth's core, DNA, waves and water molecules create.
The emergence of Magnetic Field, Gravitational Wave and High Temperature
The above equation shows that the black DNA brane in the nucleus can produce the expected gravitational energy. Clearly, for a DNA black brane with a size about 109 times larger than the Earth's core, the temperature will be around 6000 K.
Telecommunication by Waves, DNAs, Dark DNAs and Molecules of Water
It is concluded that a DNA black brane with 109 meters compacted inside the core can produce all known physics of Earth. The above comparison shows that there is a large system of telecommunications formed by the core of the earth, DNAs, waves, molecules of water and dark DNAs in an extra dimension.
Some Results Of The Existence Of The Biggest System Of Telecommunication
On the other hand, the dark DNA brane of the earth can emit some special waves in the water molecules and extract the dark DNAs from the extra. This means that the origin of life may be a telecommunication system which is formed from the interior of the earth from black DNA, dark DNAs, waves and water molecules.
Patients with AN indicated that they were investigated for other symptoms of the metabolic syndrome such as blood pressure (BP), fasting lipoprotein profile, fasting glucose, hemoglobin A1C, fasting insulin, alanine aminotransferase (ALT), hyperlipidemia, or hyperuricemia [17]. Association between acanthosis nigricans and other cardiometabolic risk factors in overweight and obese children and adolescents.
Recovery of Brain in Chick Embryos by Growing Second Heart and Brain
On the other hand, the existence of the cerebellum in the heart may help the head transplant and make it possible. Apart from these considerations, one of the interesting claims in head transplantation is made by Sergio Canavero.
A review of connections between nervous and circulatory systems
This transplantation is possible if there is a second brain to perform brain activities in the absence of the head. This causes the formation of new blood cells in the bone marrow and new neural stem cells in the subventricular zone (SVZ) of the brain.
Two methods for recovering injured and dead brains
There are some connections between the nervous system and the heart which are known as cardiac ganglia. There are also some connections between the circulatory system and the neural network in the brain (see Figure 2).
Testing the model for chick embryos
We tested the model in chick embryos and showed that transplantation has a direct effect on neural circuits. HEMEL: The main anastomosis undertaking Project outline for the first human head transplant with spinal coupling.
New Trends in Cutaneous Melanoma Surgery
Management of primary lesion
The surgical margins to be removed are based on the maximum Breslow thickness of the melanoma [4]. Typically, all suspicious pigmented lesions should be removed with a clear clinical margin of at least 2 mm but not greater than 5 mm so as not to damage lymphatic drainage, which should be assessed by a subsequent SLNB.
Sentinel lymph node biopsy and Complete lymph node dissection
Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicenter, randomized phase 3 trial. Identification of patients with intermediate-thickness and low-risk melanoma for sentinel lymph node positivity.
Anetoderma Schweninger-Buzzi: Two Case Reports
Successful treatment of the underlying pathology may result in prevention of the development of additional lesions. Laser therapy has been used to improve appearance by stimulating elastic fiber production and reducing fiber fragmentation following a combined 595 nm pulsed dye laser plus 1550 nm non-ablative fractionated laser [22].
DNA Waves and Their Applications in Biology
Over time, the number of DNA packets (ie, bacteria) in the milk increases and more waves are released. The movements of charged particles and electrons depend on the topology of the chromosomes and the type of wrapping, coiling and packaging of the DNA in them.
The Effects of Magnesium – Melatonin - Vit B Complex Supplementation in Treatment of Insomnia
Our study aimed to evaluate the efficacy of magnesium-melatonin-vitamin B complex supplement in the treatment of insomnia. Our findings indicate that 3 months of supplementation with magnesium-melatonin-vitamin B complex has a beneficial effect in the treatment of insomnia, regardless of the cause.
In Ovo Sexing of Chicken Eggs by Virus Spectroscopy
We use these properties to determine the sex of chicken embryos in ovo and ex ovo. In Figure 8 we compare radiated signals from male-sexed chicken embryos to female-sexed chicken embryos.
Beta Blockers and Melanoma
This is a sign of exchanged waves between neural circuits and structures within the earth's core. In section IV we recover exchanged waves between neural circuits and filamentous anti-DNA within the earth's core in the.
Psychotherapy Role in Treatment of Chronic Spontaneous Urticaria in a 32 Years Old Female Patient
Therefore, acute stress can lower the threshold for urticaria and influence the severity of the disease. It is safe to assume that this led to the development of chronic spontaneous urticaria and periodic exacerbations as emotional stress repeated and became worse.
A Mathematical Model for the Signal of Death and Emergence of Mind Out of Brain in Izhikevich Neuron Model
The above equation shows that the Hamiltonian of the spinal cord depends on the Hamiltonian of the brain. However, our calculations show that the Hamiltonian of the spinal cord depends on the Hamiltonian of the brain.
