12 Table Supplemental Digital Content: Baseline characteristics, diagnosis and relevant laboratory results of all patients with low-mitogen indeterminate QFT-G-IT results.
Age (year)/sex
Lymphocyte count (x109/L)
Presenting condition Reason for QFT-G-IT test Final diagnosis HIV status
13.4/M 2.16 Previously healthy Case report Sarcoidosis N
7.9/F ND Previously healthy
Born in Peru, household contact with TB, CXR normal, TST was 0 mm initially and 10 weeks after BIC. No TB disease
symptoms.
Diagnosed with SLE and pancytopenia
UK 0.9/M 0.99 Possible SCID on IGIV
every 3 weeks.
Fever and colitis, Canadian born, no TB contact, normal chest radiograph (CXR), ID work up negative, no TST.
Dyskeratosis
congenita UK 2.5/M 4.28 Suspected HLH, BMA
no malignancy.
Fever; increase WOB, left pneumonia and pleural effusion.
Received dexamethasone before IGRA. Canadian born, no TB contact.
Atypical HUS UK 3.2/M 0.11 Neuroblastoma stage IV
on chemotherapy
Pre transplant CT chest showed 2 mm calcified pulmonary nodule in left lower lobe. Canadian born, no TB contact.
Neuroblastoma
stage IV N
3.5/M 0.45
Glycogen storage disease type IV post
liver transplant
Neck pain, CT neck showed erosive lesions in C1 and C2.
TB work up before starting adalimumab. Canadian born, no TB contact, TST negative, CXR normal.
Glycogen storage disease type IV post
liver transplant
UK 3.8/M 1.16 New ALL on induction
chemotherapy.
Fever, cough, intrathoracic LN, Canadian born, travelled to
El Salvador, no TB contact Pre B ALL UK
4.6/M 6
Chronic generalized dermatopathy,
leukocytosis, eosinophilia and
thrombocytosis.
Fever, arthritis, osteomyelitis, generalized LN, Radiologic evidence of osteomyelitis and soft tissue inflammation.
Canadian born, no TB contact.
Langerhans cell histocytosis.
Hypereosinophilia with episodic
angioedema.
N
14.5/M 1.14
HLH/MAS on cyclosporine and
dexamethasone.
SOB and lethargy. CXR showed ground glass appearance, ill-defined nodules in lower lobes. TST 0 mm. Canadian
born, parents from Sudan, no TB contact.
HLH, CMV
pneumonitis. N
13 Legend:
M, male; F, female; SCID, severe combined immunodeficiency; IGIV, immunoglobulin intravenous; TST, tuberculin skin test; ID, infectious disease; UK, unknown; N, negative;
HLH, hemophagocytic lymphohistocytosis; BMA, bone marrow aspirate; WOB, work of breathing; QFT-G-IT, QuantiFeron Gold In Tube; HUS, hemolytic uremic syndrome; CT, computerized tomography; TB, tuberculosis; ALL, acute lymphoblastic leukemia; LN, lymph adenopathy; BIC, break in contact date; SLE, systemic lupus erythematosus; MAS, macrophage activation syndrome; SOB, shortness of breath; CMV, cytomegalovirus.