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Table S1: Characteristics of study population with OTHER diagnosis (non-HCV, non-NASH, non-Alcohol), compared to Alcohol Diagnosis, by HCC listed for liver transplant from 1995 to 2015

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Table S1: Characteristics of study population with OTHER diagnosis (non-HCV, non-NASH, non-Alcohol), compared to Alcohol Diagnosis, by HCC listed for liver transplant from 1995 to 2015

OTHER diagnosis, with Alcohol Diagnosis Removed

[non-HCV, non-NASH, non-Alcohol]

(n=68 566)

Alcohol diagnosis (n=28 638)

Non-HCC n=60 416

HCC n=8150

Non-HCC n=25 886

HCC n=2752 Gender, n (%)

Female 31 726

(52)

2199 (27)

6739 (26)

303 (11)

Male 28 690

(48)

5951 (73)

19 147 (74)

2449 (89)

Age (years), median (IQR)

44 (21-55)

57 (51-63)

53 (47-59)

59 (54-64)

Ethnicity, n (%)

White 40 565

(67)

4550 (56)

20 411 (79)

1964 (71)

Black 7527

(13)

738 (9)

1007 (4)

72 (3)

(2)

(13) (12) (15) (23)

Asian 3415

(6)

1809 (22)

328 (1)

55 (2)

Other 1032

(2)

104 (1)

357 (1)

34 (1) Birth cohort, n (%)

1936-1940 3880

(6)

707 (9)

1874 (7)

232 (8)

1941-1945 5961

(10)

1234 (15)

3480 (13)

523 (19)

1946-1950 7607

(13)

1805 (22)

4947 (19)

721 (26)

1951-1955 7174

(12)

1895 (23)

4988 (19)

608 (22)

1956-1960 5807

(10)

1199 (15)

4269 (17)

361 (13)

1961-1965 4428

(7)

540 (7)

3175 (12)

202 (7)

1966-1970 3357

(6)

243 (3)

1655 (6)

68 (3)

1971+ 22 202

(37)

527 (7)

1498 (6)

37 (1)

Diabetes, n (%) 5457 1856 4576 934

(3)

(9) (23) (18) (34)

Transplanted, n (%) 34 383 (57)

5573 (68)

11 797 (46)

2046 (74)

(4)

Figure S1. Observed Liver Transplant Registration Rates among patients with HCV, by Age Group

(5)

Figure S2. Observed Liver Transplant Registration Rates among patients with OTHER, by Age Group

(6)

Figure S3. Observed Liver Transplant Registration Rates among Patients with NASH and HCC, by Age Groups

(7)

Figure S4. Observed Liver Transplant Registration Rates among Patients with HCV and HCC, by Age Groups

(8)

Figure S5. Observed Liver Transplant Registration Rates among Patients with NASH and No HCC, by Age Groups

(9)

Figure S6. Observed Liver Transplant Registration Rates among Patients with HCV and No HCC, by Age Groups

(10)

Figure S7. Observed and Projected Trends in Liver Transplant Registration among patients with HCV, by Birth-cohort

Legend: a: 1936-1940 birth-cohort; b: 1941-1945 birth-cohort; c: 1946-1950 birth-cohort; d:

1951-1955 birth-cohort; e: 1956-1960 birth-cohort; f: 1961-1965 birth-cohort; g: 1966-1970 birth- cohort; h: 1971-2015 birth-cohort

(11)

Figure S8: Observed and Projected Trends in Liver Transplant Registration among Patients with HCV and HCC, by Birth-cohort

Legend: a: 1936-1940 birth-cohort; b: 1941-1945 birth-cohort; c: 1946-1950 birth-cohort; d:

1951-1955 birth-cohort; e: 1956-1960 birth-cohort; f: 1961-1965 birth-cohort; g: 1966-1970 birth- cohort; h: 1971-2015 birth-cohort

(12)

Figure S9: Observed and Projected Trends in Liver Transplant Registration among Patients with HCV and No HCC, by Birth-cohort

Legend: a: 1936-1940 birth-cohort; b: 1941-1945 birth-cohort; c: 1946-1950 birth-cohort; d:

1951-1955 birth-cohort; e: 1956-1960 birth-cohort; f: 1961-1965 birth-cohort; g: 1966-1970 birth- cohort; h: 1971-2015 birth-cohort

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