Supplementary Figure 1: Funnel plot signifying visible asymmetry with SADR ((AEYE: AmplifEYE, CE: Chromoendoscopy, CTC: CT colonography, CWE: Chromoendoscopy + water exchange, CWI: Chromoendoscopy + water immersion/infusion, CWR: ColoWrap, ECA: Endocap, ECU: Endocuff, ECV, endocuff vision, ER: Endoring, FUSE: Full spectrum, GE: G-EYE, HD: High-definition standard colonoscopy, LCI: Linked color imaging, NBI: Narrow band imaging, WE: Water exchange, WI: Water immersion/infusion).
Supplementary Figure 2: Forrest plot comparing SADR for HD colonoscopy to WBT. (CI: Confidence interval, HD: High definition colonoscopy, SADR: Serrated adenoma detection rate, WBT: Water-based techniques).
Supplementary Figure 3: Forrest plot comparing SADR for HD colonoscopy to AD. (AD: Add-on devices, CI: Confidence interval, HD:
High definition colonoscopy, SADR: Serrated adenoma detection rate).
Supplementary Figure 4: Forrest plot comparing SADR for HD colonoscopy to NBI. (CI: Confidence interval, HD: High definition colonoscopy, NBI: Narrow band imaging, SADR: Serrated adenoma detection rate).
Supplementary Figure 5: Forrest plot comparing SADR for HD colonoscopy to ECV. (CI: Confidence interval, ECV: Endocuff vision, HD:
High definition colonoscopy, SADR: Serrated adenoma detection rate).
Supplementary Figure 6: Forrest plot comparing SADR for HD colonoscopy to EC. (CI: Confidence interval, EC: Electronic chromoendoscopy, HD: High definition colonoscopy, SADR: Serrated adenoma detection rate).
Supplementary Figure 7: Forrest plot comparing SADR for HD colonoscopy to WE. (CI: Confidence interval, HD: High definition colonoscopy, SADR: Serrated adenoma detection rate, WE: Water exchange).
Supplementary Figure 8: Forrest plot comparing SADR for HD colonoscopy to ECA. (CI: Confidence interval, ECA: Endocap, HD: High definition colonoscopy, SADR: Serrated adenoma detection rate).
Supplementary Figure 9: Forrest plot comparing SLDR for HD colonoscopy to CE. (CE: Chromoendoscopy, CI: Confidence interval, HD:
High definition colonoscopy, SLDR: Serrated lesion detection rate).
Supplementary Figure 10: Forrest plot comparing SLDR for HD colonoscopy to AD. (AD: Add-on devices, CI: Confidence interval, HD:
High definition colonoscopy, SLDR: Serrated lesion detection rate).
Supplementary Figure 11: Forrest plot comparing SLDR for HD colonoscopy to EC. (CI: Confidence interval, EC: Electronic chromoendoscopy, HD: High definition colonoscopy, SLDR: Serrated lesion detection rate).
Supplementary Figure 12: Forrest plot comparing SLDR for HD colonoscopy to FUSE. (CI: Confidence interval, FUSE: Full spectrum endoscopy, HD: High definition colonoscopy, SLDR: Serrated lesion detection rate).
Supplementary Figure 13: Forrest plot comparing SLDR for HD colonoscopy to ECU. (CI: Confidence interval, ECU: Endocuff, HD: High definition colonoscopy, SLDR: Serrated lesion detection rate).
Supplementary Figure 14: Forrest plot comparing SLDR for HD colonoscopy to NBI. (CI: Confidence interval, HD: High definition colonoscopy, NBI: Narrow band imaging, SLDR: Serrated lesion detection rate).
Supplementary Figure 15: Forrest plot comparing SLDR for HD colonoscopy to ECA. (CI: Confidence interval, ECA: Endocap, HD: High definition colonoscopy, SLDR: Serrated lesion detection rate).
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Supplementary Figure 16: Network meta-analysis comparing individual intervention to HD colonoscopy for SLDR (A) Network geometry of trials. Size of the node and thickness of the edges are weighted according to the number of studies evaluating each intervention and direct comparison (B) Forrest plot comparing individual intervention to HD colonoscopy. (AEYE: AmplifEYE, CE:
Chromoendoscopy, CI: Confidence interval, CTC: CT colonography, CWE: Chromoendoscopy + water exchange, CWI:
Chromoendoscopy + water immersion/infusion, CWR: ColoWrap, ECA: Endocap, ECU: Endocuff, ECV, endocuff vision, ER: Endoring, FUSE: Full spectrum, GE: G-EYE, HD: High-definition standard colonoscopy, LCI: Linked color imaging, NBI: Narrow band imaging, RR:
Risk Ratio, SLDR: Serrated lesion detection rate, WE: Water exchange, WI: Water immersion/infusion).
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Supplementary Figure 17: Network meta-analysis comparing intervention groups to HD colonoscopy for SLDR (A) Network geometry of trials for SLDR. Size of the node and thickness of the edges are weighted according to the number of studies evaluating each intervention group and direct comparison (B) Forrest plot comparing intervention groups to HD colonoscopy. (AD: Add-on devices, CE: Chromoendoscopy, CI: Confidence interval, CM: Combination modalities, CWR: ColoWrap, EC: Electronic Chromoendoscopy, HD:
High-definition standard colonoscopy, NS: Newer scopes, RR: Risk ratio, SLDR: Serrated lesion detection rate, WBT: Water-based techniques).
