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Supplementary Appendix

Table S1: The socioeconomic status (DPI、CE、Healthcare、GDP) in different regions of china in 2016 year.

DPI=Disposable Personal Income, CE=Consumption Expenditure, GDP= Gross Domestic Product;

Measurements National China Eastern Region Central Region Western Region DPI, yuan 23785.06±9715.09 27883.81±7730.38 20407.50±615.07 17268.05±1999.94 CE, yuan 17200.67±6499.51 20028.99±5496.14 14573.53±1251.67 13201.13±1435.23 Healthcare, yuan 1356.04±484.94 1438.44±345.91 1007.20±213.33 1199.98±234.12

Healthcare /CE(%) 7.88 7.18 6.91 9.10

GDP, billion yuan 8352.67±6864.75 10362.37±6615.66 6694.91±2576.06 6247.93±4271.52

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Table S2 The distribution of stroke risk factors in urban or rural residents of different economic region in 2016

Risk factors National China Eastern Region1 Central Region2 Western Region3

Urban Rural Urban Rural Urban Rural Urban Rural Hypertension 7958(50.7) 18026(49.6) 3476(54.2) 3328(53.8) 1458(39.0) 1267(48.2) 3024(54.7) 5473(46.2) Diabetes mellitus 7081(45.1) 18935(52.1) 2042(31.8) 2777(44.9) 2728(73.0) 1471(56.0) 2311(41.8) 7606(64.3) Dyslipidemia 2587(16.6) 4626(12.7) 1241(19.3) 683(11.0) 408(10.9) 402(15.3) 938(17.0) 954(8.1) Heart disease 5273(33.6) 11466(31.6) 2716(42.3) 2341(37.8) 816(21.8) 600(22.8) 1741(31.5) 3252(27.5) Smoking 4681(29.8) 12459(34.3) 1681(26.2) 2521(40.7) 955(25.5) 1172(44.6) 2045(37.0) 4085(34.5) Overweight 3752(23.9) 8345(23.0) 1642(25.2) 1242(20.1) 654(17.5) 561(21.3) 1456(26.3) 2790(23.6) Physical inactivity 4973(31.7) 11529(31.7) 2063(32.1) 1954(31.6) 990(26.5) 705(26.8) 1920(34.7) 3897(32.9) Family history of stroke 1628(10.4) 3322(9.1) 801(12.5) 742(12.0) 440(11.8) 217(8.3) 387(7.0) 735(6.2)

Table S3 The distribution of stroke risk factors in National China according to annual revenue in 2016

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Annual revenue (yuan, RMB) <5000 5000-10000 10001-20000 >20000 Hypertension 6173(51.6) 3333(52.8) 2537(49.7) 5983(46.2) Diabetes mellitus 6390(53.4) 3349(53.1) 2547(49.9) 6649(51.3)

Dyslipidemia 1038(8.7) 910(14.4) 737(14.4) 1941(15.0)

Heart disease 3723(31.1) 1677(26.6) 1620(31.7) 4446(34.3)

Smoking 3629(30.3) 1996(31.6) 1973(38.6) 4861(37.5)

Overweight 2598(21.7) 1409(22.3) 1284(25.1) 3054(23.6)

Physical inactivity 3886(32.5) 22.01(34.9) 1837(36.0) 3605(27.8) Family history of stroke 725(6.1) 565(9.0) 436(8.5) 1596(12.3)

Table S4 The distribution of stroke risk factors in Eastern region according to annual revenue in 2016

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Annual revenue (yuan, RMB) <5000 5000-10000 10001-20000 >20000 Hypertension 1588(61.2) 1225(62.4) 1107(54.6) 2884(47.9) Diabetes mellitus 968(37.3) 715(36.4) 829(40.9) 2307(38.3)

Dyslipidemia 288(11.1) 274(14.0) 294(14.5) 1068(17.7)

Heart disease 932(35.9) 590(30.1) 758(37.4) 2777(46.1)

Smoking 745(28.7) 563(28.7) 719(35.5) 2175(36.1)

Overweight 463(17.8) 410(30.9) 483(23.8) 1528(25.4)

Physical inactivity 952(36.7) 691(35.2) 750(37.0) 4396(73.0) Family history of stroke 236(9.1) 186(9.5) 229(11.3) 892(14.8)

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Table S5 The distribution of stroke risk factors in Central region according to annual revenue in 2016

Annual revenue (yuan, RMB) <5000 5000-10000 10001-20000 >20000

Hypertension 332(31.7) 524(52.2) 499(52.7) 1370(40.7)

Diabetes mellitus 729(69.7) 550(54.8) 500(52.8) 2420(71.8)

Dyslipidemia 106(10.1) 239(23.8) 119(12.6) 346(10.3)

Heart disease 176(16.8) 224(22.3) 252(26.2) 764(22.7)

Smoking 382(36.5) 256(25.5) 290(30.6) 1199(35.6)

Overweight 153(14.6) 222(22.1) 190(20.1) 650(19.3)

Physical inactivity 373(35.7) 349(34.8) 231(24.4) 2628(78.0) Family history of stroke 44(4.2) 127(12.6) 95(10.0) 391(11.6)

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Table S6 The distribution of stroke risk factors in Western region according to annual revenue in 2016

Annual revenue (yuan, RMB) <5000 5000-10000 10001-20000 >20000

Hypertension 4253(51.1) 1584(47.4) 931(43.6) 1729(48.4) Diabetes mellitus 4693(56.4) 2084(62.3) 1218(57.1) 1922(53.8)

Dyslipidemia 644(7.7) 397(11.9) 324(15.2) 527(14.8)

Heart disease 2615(31.4) 863(25.8) 610(28.6) 905(25.3)

Smoking 2502(30.1) 1177(35.2) 964(45.2) 1487(41.6)

Overweight 1982(23.8) 777(23.2) 611(28.6) 876(24.5)

Physical inactivity 2561(30.8) 1161(34.7) 856(40.1) 2332(65.3) Family history of stroke 445(5.4) 252(7.5) 112(5.2) 313(8.8)

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