Core Outcome Set for Evaluating Interventions to Prevent Preterm Birth

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van ’t Hooft J, Duffy JMN, Daly M, Williamson PR, Meher S, Thom E, et alA core outcome set for evaluation of interventions to prevent preterm birth. Obstet Gynecol 2016;127.

The authors provided this information as a supplement to their article.

Outcome

First round results participants responding to both rounds (n=174) Median (IQR)

First round results non- responders to second round (n=21)

Median (IQR)

Second round results participants not attending consultation meeting (n=163) Median (IQR)

Second round results participants attending

consultation meeting (n=11

^*

) Median (IQR)

Gestational age at delivery 8 (7-9) 7 (6-9) 8 (8-9) 9 (8-9)

Prelabor rupture of membranes 7 (6-8) 7 (6-8,5) 7 (7-8) 7 (6-8)

Maternal infection or inflamation

7 (6-9) 8 (7-9) 7 (7-8) 7 (6-8)

Cervical length 6 (5-8) 5 (4,25-8) 6 (5-7) 6 (5-7)

Biophysical profile measures 6 (4-7) 6,5 (5-8) 6 (5-6) 5 (5-6)

Mode of delivery 6 (5-8) 6 (4,25-7,75) 6 (6-7) 6 (6-7)

Maternal mortality 9 (7-9) 8 (6-9) 8 (8-9) 8 (7-9)

Parental mental health morbidity

6 (4-7) 6 (5-7) 6 (5-7) 5 (5-6)

Parental social morbidity 6 (4-7) 6 (4,25-7) 6 (5-6) 5 (4-6)

Reproductive morbidity 7 (6-8) 6,5 (6-7) 7 (6-7) 6 (5-7)

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Offspring mortality 9 (8-9) 9 (8-9) 9 (9-9) 9 (9-9)

Offspring infection 8 (7-9) 8 (7-8,5) 8 (7-9) 8 (6-8)

Respiratory morbidity 8 (7-9) 8 (8-9) 8 (8-8) 8 (7-8)

Early neurodevelopmental morbidity

8 (7-9) 8 (8-9) 8 (8-9) 8 (8-9)

Late neurodevelopental morbidity

9 (7-9) 8 (8-9) 8 (8-9) 8 (8-9)

Gastro-intestinal morbidity 8 (7-9) 8 (7,25-9) 8 (7-8) 8 (7-8)

Circulatory Morbidity - - 7 (6-8) 7 (6-8)

Metabolic Morbidity - - 7 (6-8) 6 (6-8)

Congenital abnormalities 7 (6-8) 6 (4,5-8,5) 7 (6-8) 7 (5-8)

Birth weight 7 (6-8) 7 (6-8) 7 (7-8) 7 (7-8)

Condition newborn immediately after birth

7 (5-8) 7 (6-8) 7 (6-8) 7 (5-8)

Growth after birth 7 (6-8) 7 (6-8) 7 (6-7) 7 (6-8)

Social morbidity offspring 6 (4-7) 6 (5,5-7) 6 (5-7) 5 (4-7)

Health service utilization 6 (5-7) 6 (5,5-7,5) 6 (6-7) 6 (5-8)

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Appendix 4. Attrition Assessment

Median (Interquartile range) of GRADE scores on a 1-9 Likert scale of the 1

^st

round Delphi survey of a) all participants b) participants that did not participate on the 2

^nd

round Delphi. Median GRADE scores on a 1-9 Likert scale of the 2

^nd

round Delphi survey of c) all participants d) participants that did participate in the consultation meeting.

*= eleven of the 29 participants of the consultation meeting did also participate in the 1

^st

and 2

^nd

round Delphi survey.

mother/direct costs Health service utilization offspring/direct costs

7 (6-8) 7,5 (6,25-8) 7 (6-7) 7 (6-8)

Societal service utilization parents/indirect costs

6 (5-7) 6 (5,25-8) 6 (6-7) 6 (6-6)

Societal service utilization offspring/indirect costs

6 (5-7) 7 (6-8) 6 (6-7) 6 (5-7)

Patient reported outcome measures

6 (5-7) 7 (5-7) 6 (6-7) 6 (5-7)

Harm 7 (7-8) 7 (6-8) 7 (7-8) 8 (7-8)

Compliance with intervention 7 (6-8) 7 (6-8) 7 (7-8) 7 (6-8)

Breastfeeding 6 (5-8) 7 (5,5-8) 6 (6-7) 6 (4-7)