Supplementary Table 1. Sensitivity, specificity, PPV and NPV for the CTP, ALBI, and 6 MELD-based
models in predicting in-hospital, 3-month, and 6-month mortalities of SBP with the best cutoffs
Cutoffs of scoring system
Sensitivity (%) Specificity (%) PPV (%) NPV (%)
In-hospital mortality
CTP > 9.5 87/123(71) 116/188(62) 87/159(55) 116/152(76) MELD > 23.7206 82/125(66) 144/189(76) 82/127(65) 144/187(77) MELD-Na > 28.0 75/125(60) 152/189(80) 75/112(67) 152/202(75)
iMELD > 48.8 81/125(65) 150/189(79) 81/120(68) 150/194(77)
MESO > 18.6 79/125(63) 148/189(78) 79/120(66) 148/194(76) RefitMELD > 23.3 84/125(67) 141/189(75) 84/132(64) 141/182(77.5) RefitMELDNa > 24.4 77/125(62) 156/189(83) 77/110(70) 156/204(77) ALBI > -0.70 73/125(60) 129/189(68) 73/133(54) 130/178(73) 3-month mortality
CTP > 9.5 102/160(64) 94/151(62) 102/159(64) 94/152(62) MELD > 23.7 99/162(61) 124/152(82) 99/127(78) 124/187(66) MELD-Na > 26.2 104/162(64) 115/152(76) 104/141(74) 115/173(67)
iMELD > 48.6 95/162(59) 127/152(84) 95/120(79) 127/194(66)
MESO > 17.9 98/162(61) 124/152(82) 98/126(78) 124/188(66) RefitMELD> 23.3 102/162(63) 122/152(80) 102/132(77) 122/182(67) RefitMELDNa> 23.4 97/162(60) 124/152(82) 97/125(78) 124/189(66)
ALBI > -0.64 83/157(53) 116/154(75) 83/121(69) 116/190(61) 6-month mortality
CTP > 9.5 113/187(60) 78/124(63) 113/159(71) 78/152(51) MELD > 23.7 105/189(56) 103/125(82) 105/127(83) 103/187(55) MELD-Na > 26.2 112/189(59) 96/125(77) 112/141(79) 96/173(56)
iMELD > 49.8 95/189(50) 109/125(87) 95/111(86) 109/203(54)
MESO > 17.9 104/189(55) 103/125(82) 104/126(83) 103/188(55) RefitMELD> 23.7 105/189(56) 103/125(82) 105/127(83) 103/187(55) RefitMELDNa> 24.1 96/189(51) 108/125(86) 96/113(85) 108/201(54) ALBI > -0.71 100/184(54) 90/127(71) 100/137(73) 90/174(52)
PPV: positive predictive value; NPV: negative predictive value; SBP: spontaneous bacterial peritonitis
* Cutoffs of each scoring system were derived from the receiver operating characteristic curve
Supplementary Table 2A.Univariable and multivariable logistic regression analysis for prediction of in-hospital mortality of patients with SBP in relation to baseline parameters
Variables Crude OR (95%CI) P value Adjusted OR (95% CI) P value
Age 1.018(1.001-1.036) 0.036 1.059(1.031-1.089) <0.001
Sex 0.837(0.509-1.377) 0.483
Etiology 1.125(0.886-1.429) 0.333 Ascites 1.545(1.131-2.110) 0.006 HE 1.508(1.219-1.866) <0.001
HRS 11.477(4.303-30.608) <0.001 4.470(1.341-14.894) 0.015
Anti-viral 0.656(0.313-1.375) 0.264
Creatinine 1.419(1.227-1.640) <0.001 1.541(1.229-1.933) <0.001 Na 1.003(0.968-1.040) 0.850
K 1.295 (0.995-1.685) 0.055 Ammonia 1.005(1.001-1.008) 0.004 AST 1.001(1.000-1.001) 0.232 ALT 1.003(1.000-1.006) 0.079
T. Bil. 1.093(1.058-1.128) <0.001 1.136(1.074-1.201) <0.001 Albumin 0.774(0.477-1.257) 0.301
INR 2.943(1.965-4.408) <0.001 Hb 1.046(0.928-1.179) 0.461 WBC 1.070(1.033-1.109) <0.001
Platelet 1.002(0.999-1.005) 0.154 1.007(1.002-1.011) 0.003 Ascites PMN 1.000(1.000-1.000) 0.922
The C-index for prediction of in-hospital mortality in this multivariable logistic regression model was 0.807 with 95% CI (0.758-0.856), P<0.001
Supplementary Table 2B. Univariable and multivariable logistic regression analysis for prediction of 3-month mortality of patients with SBP in relation to baseline parameters
Variables Crude OR (95%CI) P value Adjusted OR (95% CI) P value
Age 1.013(0.996-1.029) 0.135 1.067(1.019-1.117) 0.006
Sex 1.036(0.635-1.690) 0.886
Etiology 1.053(0.833-1.330) 0.668 Ascites 1.217(0.914-1.622) 0.179 HE 1.294(1.048-1.598) 0.017 HRS 6.692(2.517-17.791) <0.001 Anti-viral 0.539(0.262-1.110) 0.094
Creatinine 1.331(1.150-1.541) <0.001 2.401(1.300-4.433) 0.005 Na 0.983(0.949-1.018) 0.335
K 1.296(0.999-1.682) 0.051 Ammonia 1.004(1.001-1.008) 0.008 AST 1.001(1.000-1.001) 0.293 ALT 1.003(0.999-1.006) 0.103
T. Bil. 1.107(1.066-1.150) <0.001 1.104(1.010-1.206) 0.030 Albumin 0.664(0.412-1.068) 0.091
INR 2.560(1.705-3.845) <0.001 Hb 0.987(0.878-1.110) 0.827 WBC 1.048(1.014-1.084) 0.005 Platelet 1.001(0.998-1.003) 0.534 Ascites PMN 1.000(1.000-1.000) 0.459
The C-index for prediction of 3-month mortality in this multivariable logistic regression model was 0.730 with 95% CI (0.674-0.786), P<0.001
Supplementary Table 2C. Odds ratios for 6-month mortality of SBP in relation to baseline parameters
Variables Crude OR (95%CI) P value Adjusted OR (95% CI) P value
Age 1.015(0.98-1.032) 0.090 1.044(1.003-1.087) 0.035
Sex 1.088(0.662-1.787) 0.739
Etiology 1.047(0.825-1.329) 0.708 Ascites 1.278(0.957-1.706) 0.096 HE 1.210(0.975-1.502) 0.084 HRS 4.544(1.709-12.083) 0.002 Anti-viral 0.450(0.216-0.939) 0.033
Creatinine 1.295(1.110-1.510) 0.001 4.018(1.626-9.926) 0.003 Na 0.973(0.939-1.009) 0.144
K 1.226(0.941-1.597) 0.131 Ammonia 1.004(1.000-1.007) 0.032 AST 1.000(0.999-1.001) 0.506 ALT 1.002(0.999-1.005) 0.238 T. Bil. 1.092(1.051-1.134) <0.001 Albumin 0.769(0.476-1.243) 0.283
INR 2.487(1.617-3.827) <0.001 Hb 0.979(0.869-1.103) 0.728 WBC 1.080(1.036-1.127) <0.001 Platelet 1.003(1.000-1.006) 0.054 Ascites PMN 1.000(1.000-1.000) 0.210
The C-index for prediction of 6-month mortality in this multivariable logistic regression model was was 0.674 with 95% CI (0.613-0.735), P<0.001