Supplemental digital content 3: Table. Study cohort characteristics: disease location and behavior
Author Sample size CD N(%) UC
Arcos-
Machancoses (16)
CD 31 UC 19 IBDU 3
Location - Paris L1: 11 (36) L2: 4 (13) L3: 10 (32) L1+L4a: 1 (3) L1+L4b: 5 (16) Behavior - Paris B1: 16 (52) B2: 9 (29) B2p: 2 (7) B3: 1 (3) B3p: 2 (7) B2B3: 3 (10)
Location - Paris E1: 1 (5)
E2: 4 (21) E3: 1 (5) E4: 13 (68)
Avinash (17) CD 23 UC 11
Location
Ileocolonic: 13 (57) Colonic: 8 (35) Ileal: 2 (9)
Location Proctitis: 2 (18) Pancolitis: 9 (82)
Czkwianianc (18) CD 39 -
De Greef (19) CD 255 Location - Paris L1: 32 (13) L2: 62 (24) L3: 157 (62) L4: 4 (2) L4a: 144 (56) L4b: 83 (32)
Duricova (20) UC 158 Location - Montreal
E1: 40 (25) E2: 60 (38)
E3: 58 (37) El Mouzan (21) CD 240
UC 183
Location - Montreal L1: 69 (34)
L2: 31 (15) L3: 98 (48) L4: 4 (2)
Behavior - Montreal B1: 160 (68)
B2: 44 (19) B3: 15 (6) B2B3: 16 (7)
Location - Paris E1: 15 (9) E2: 38 (22) E3: 34 (20) E4: 83 (49)
Gerasimidis (22) CD 122 (66%) UC 51 (28%) IBDU 11 (6%)
Location - Montreal L1: 2 (2)
L2: 16 (14) L3: 22 (20) L4: 2 (2) L2+L4: 22 (19) L3+L4: 48 (43) Behavior - Montreal B1: 98 (87)
B2: 10 (9) B3: 5 (4)
Location - Montreal E1: 0
E2: 7 (12) E3: 50 (88)
Gower-Rousseau (23)
UC 113 Location - Montreal
E1: 32 (28) E2: 39 (35) E3: 42 (37) Greuter (24) CD 173 (53%)
UC/IBDU 156 (47%)
Location - Montreal L1: 23 (13)
L2: 22 (13) L3: 119 (69) L4: 3 (2)
Location - Montreal E1: 13 (8)
E2: 28 (18) E3: 104 (67)
Herzog (25) CD 105 (54%) Location Location
UC/IC 91 (46%) Ileocolonic: 74 (70) Colonic: 16 (15) Ileal: 10 (10) Upper GI: 28 (27) Behavior
Non-stricturing/penetrating: 66 (63) Stricturing: 10 (10)
Penetrating internal: 5 (5) Penetrating perianal: 34 (32)
Proctitis: 7 (8) Left colon: 13 (14) Pancolitis: 67 (74)
Krishna (26) UC 106 -
Nambu (27) UC 63 Location - Paris
E4: 47 (75) Ricciuto (28) CD 65
UC/IBDU 46
Location Ileal only: 12 (11) Perianal involvement: 27 (25)
Oral involvement: 5 (5)
Rinawi (29) UC 188 Location - Paris
E1: 45 (24) E2: 58 (31) E3: 26 (14) E4: 59 (31)
Sadaah (30) UC 57 Location
Extended colitis: 44 (77) Left colitis: 7 (12) Distal colitis: 6 (11)
Samson (31) CD 27 Location
Small bowel and colon: 16 (59) Small bowel only: 4 (15) Colon only: 7 (26)
Anoperineal involvement: 7 (26)
Savoye (32) CD 535 Location - Montreal
L1: 40 (13)
L2: 44 (14) L3: 191 (62) L4: 75 (24)
Behavior - Montreal B1: 222 (72)
B2: 79 (26) B3: 8 (3) Sawzenko (33) CD 379
UC 172 IC 72
Location
Isolated small bowel: 15 (9) Isolated colonic: 9 (7)
Location
Isolated rectal: 1 (4) Pancolitis: 22 (81) Schoepfer (34) CD 387 Location - Montreal
L1: 59 (15) L2: 55 (14) L3: 236 (61) L4: 5 (1) Schoepfer (35) CD 100
UC 75
Location Ileal: 8%
Colonic: 10%
Ileocolonic: 47%
Upper GI: 2%
Location Pancolitis: 72%
Left colitis: 13%
Proctitis: 7%
Spray (36) CD 64 UC 41 IC 7
- -
Timmer (37) CD 1456 UC 817 IC 163
Location Ileal: 199 (17) Colonic: 280 (24) Ileocolonic: 658 (57) Upper GI: 438 (38) Isolated upper GI: 17 (1)
Location - Montreal E1: 18 (3)
E2: -
E3: 498 (76)
Trevino (38) CD 97 (65) UC 48 (32) IBDU 4 (3)
Location - Paris L1: 17 (18) L2: 7 (7)
Location - Paris E1: 7 (16) E2: 6 (13)
L3: 37 (38) L4a: 2 (2) L4b: 3 (3) L1L4a: 4 (4) L2L4a: 3 (3) L3L4a: 20 (21) L3L4b: 1 (1) L3L4ab: 2 (2) Behavior - Paris B1: 88 (91) B2: 5 (5) B3: 4 (4)
Perianal modifier: 18 (19)
E3: 9 (20) E4: 23 (51)
Unal (39) CD 17
UC 1
Location
Proctitis/sigmoiditis: 2 (11) Left colon: 4 (22) Pancolitis: 12 (67%) Vicentin (40) CD 20 (40)
UC 25 (50) IBDU 5 (10)
Location
Ileum and colon: 16 (80) Colon: 3 (15)
Rectum and colon: 1 (5)
Location Colon: 19 (76) Left colon: 4 (16) Rectum: 2 (8) Yap (41) CD 34 (66)
UC 9 (17) IBDU 9 (17)
Location - Montreal L1: 2 (6)
L2: 16 (48) L3: 13 (39)
L4 upper GI: 24 (73) L1L4: 1 (3)
L2L4: 10 (29) L3L4: 11 (32) Isolated L4: 2 (6) Perianal: 13 (39)
Pancolitis: 78%
Left colitis: 22%
CD = Crohn’s Disease, UC = ulcerative colitis, IC = indeterminate colitis, IBDU = IBD unclassified Crohn’s disease
Paris classification - location L1: distal 1/3 ileum
L2: colonic L3: ileocolonic
L4a: upper disease proximal to ligament of Treitz*
L4b: upper disease distal to ligament of Treitz and proximal to distal 1/3 ileum*
Montreal classification - location L1: terminal ileal/
limited cecal disease L2: colonic
L3: ileocolonic
L4*: isolated upper disease Paris classification – behavior B1: nonstricturing
nonpenetrating B2: stricturing B3: penetrating
p: perianal disease modifier
Montreal classification - behavior B1: nonstricturing, nonpenetrating B2: stricturing
B3: penetrating
B2B3: both penetrating and stricturing disease, either at the same or different times p: perianal disease modifier
Ulcerative colitis
Paris classification - location
E1: ulcerative proctitis
E2: left-sided UC (distal to splenic flexure) E3: extensive (hepatic flexure distally) E4: pancolitis (proximal to hepatic flexure) Montreal classification - location
E1: ulcerative proctitis
E2: left-sided UC (distal to splenic flexure) E3: extensive (proximal to splenic flexure)