Figure 3S – Forest plot of odds ratio of Target vessel failure using count data

(1)

Figure 1S – The PRISMA flow diagram of search and study selection process.

Records identified through database searching

(n = 597)

Screening IncludedEligibilityIdentification Additional records identified through other sources

(n = 1)

Records after duplicates removed (n = 207)

Records screened (n = 207)

Records excluded (n = 181)

Full-text articles assessed for eligibility

(n =26)

Full-text articles excluded, with reasons

(n = 19)

Studies included in qualitative synthesis

(n =7)

Studies included in quantitative synthesis

(meta-analysis) (n =7)

(2)

Figure 2S – Forest plot of odds ratio of Target lesion failure using count data.

Figure 3S – Forest plot of odds ratio of Target vessel failure using count data.

(3)

Figure 4S – Forest plot of odds ratio of stent thrombosis using count data.

Figure 5S – Forest plot of odds ratio of target vessel myocardial infarction using count data.

Figure 6S – Forest plot of odds ratio of cardiac death using count data.

(4)

Figure 7S – Forest plot of odds ratio of target lesion revascularization using count data.

Figure 8S – Forest plot of odds ratio of target vessel revascularization using count data.

(5)

Table 1S – Cochrane Risk of bias table for the included studies.

Figure 9S – Trim and fill funnel plot for target lesion failure. After adjusting for asymmetry using random effect model IRR = 0.9784 95% CI [0.7435; 1.2875]. The hollow circles represent added study to adjust for asymmetry.

Study

Randomization process

Deviations from intended interventions

Missing outcome data

Measurement of the outcome

Selection of the reported

result

Overall Bias

BIOFLOW II LOW LOW SOME CONCERNS SOME CONCERNS LOW LOW

BIOFLOW V LOW LOW SOME CONCERNS LOW LOW LOW

BIOSCIENCE LOW LOW LOW LOW LOW LOW

BIOFLOW VI LOW LOW LOW SOME CONCERNS LOW LOW

BIOSTEMI LOW LOW LOW LOW LOW LOW

BIOFLOW IV LOW LOW LOW SOME CONCERNS LOW LOW

PRISON IV LOW LOW LOW SOME CONCERNS LOW LOW

(6)

Figure 10S– Trim and fill funnel plot for target vessel failure. After adjusting for asymmetry using random effect model IRR = 0.8390 95% CI [0.6515; 1.0805]. The hollow circles represent added study to adjust for asymmetry.