Supplementary Table 1 Univariate analysis of various comorbid conditions associated with Pyogenic Liver Abscess.
Parameters PLA Controls P value
Comorbid conditions:
Chronic Liver Disease 126 (3.1%) 144 (0.4%) <0.001
Liver Transplant 316 (7.8%) 73 (0.2%) <0.001
Biliary Disease$ 314 (7.7%) 66 (0.2%) <0.001
Gall Bladder Disease 126 (3.1%) 331 (0.8%) <0.001 Primary Immunodeficiency
Disorder
72 (1.8%) 162 (0.4%) <0.001
Chronic Kidney Disease 21 (0.5%) 321 (0.8%) 0.05
Inflammatory Bowel Disease 169 (4.2%) 377 (0.9%) <0.001 Malignancy Status
Hepatobiliary malignancy GI malignancy#
Other childhood malignancy No malignancy
46 (1.1) 11 (0.3%) 390 (9.6%) 3611 (89%)
IS*
28 (0.1%) 1730 (4.3%) 38543 (95.6%)
<0.001
Focus of infection:
Severe Sepsis 249 (6.1%) 196 (0.5%) <0.001
Appendicitis 292 (7.2%) 2159 (5.4%) <0.001
Diverticulitis 11 (0.3%) 17(<0.1%) <0.001
Skin infection 153 (3.8%) 1619 (4%) 0.44
Infective Endocarditis 30 (0.7%) 54 (0.1%) <0.001
Oral Infection 25 (0.6%) 369 (0.9%) 0.05
Outcome measures:
Mortality 32 (0.8%) 263 (0.7%) 0.30
Length of Stay (Mean±SE) 14.31±0.32 4.16±0.03 <0.001 Total Charges (Mean±SE) 103,956±2969 26,910±342 <0.001
$Includes cholangitis, bile duct obstruction or perforation, fistulas, post cholecystectomy syndrome, other specified and unspecified biliary disorder.
*IS- Information suppressed.
# Gastrointestinal Malignancy
Supplementary table 2. ICD 9 codes used in the analysis.
Liver Abscess 572.0
Amebic liver abscess 0063
Candidacies 112.5, 112.89, 112.9
Liver transplant V42.7,996.82
Chronic liver disease 571.4 to 571.9
Biliary Disease 576.*
Gall bladder disease 574*, 575*
Hepatobiliary malignancy 155.*, 156.*
Other gastrointestinal malignancy 151*, 152*, 153*, 154*
Other malignancies 157*, 158*, 159*, 170*, 190*, 191*, 194*, 200*.
Streptococcal infection 038.0, 041.0
Staphylococcal infection 041.1
Pneumococcal infection 038.2, 041.2
Pseudomonas 038.43
Proteus 041.6
Hemophilus 041.5
E coli 041.4
Klebsiella 041.3
Serratia 041.3
Serratia 038.44
Anaerobes 038.3, 041.82, 041.83, 041.84.
Gram negative bacteria not otherwise specified 038.40, 038.49, 041.85 Other unspecified bacteria 038.8, 038.9, 041.81
Bacteremia/septicemia 038*
Primary immunodeficiency disorder 279*
Chronic kidney disease 585*
Inflammatory bowel disease 555*, 556*.
Diverticulitis 562*
Appendicitis 540*
Infective endocarditis 421*, 422*
Skin infection 680 to 686
Oral infection 478.21, 478.22, 478.23, 478.24
Surgical resection 500
Percutaneous liver aspiration 501.1
Cholecystectomy 510.*
ERCP 511.0, 511.1