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SUPPLEMENTARY TABLE I - Histological Diagnoses in the Study Cohort
Diagnosis No. %
Osteosarcoma 2,765 32.8%
Conventional, NOS 2,432 28.8%
Telangiectatic 83 1.0%
Small cell 18 0.2%
Secondary 29 0.3%
Parosteal 169 2.0%
Low-grade central 7 0.1%
High-grade surface 27 0.3%
Ewing sarcoma/PNET 941 11.2%
Ewing sarcoma 903 10.7%
PNET 38 0.5%
Chondrosarcoma 3,338 39.6%
Conventional, NOS 2,975 35.3%
Dedifferentiated 281 3.3%
Mesenchymal 25 0.3%
Clear cell 57 0.7%
Other 1,388 16.5%
SUPPLEMENTARY TABLE II - Surgical Margins in the Short-Distance/Low- Volume Facility and Long-Distance/High-Volume Facility Groups
Margin Status Short-Distance/Low- Volume (N=756)
Long-Distance/High- Volume (N=1,003)
Negative 531 (70.2%) 827 (82.5%)
Positive 90 (11.9%) 97 (9.7%)
Unknown 135 (17.9%) 79 (7.9%)
Data presented as numbers and percentages. Group distributions differ at p <
0.001 (chi-square test).
SUPPLEMENTARY TABLE III - Relationship Between Patient’s Insurance Type and Facility Volume
Facility Volume Private Medicare Medicaid Other
Government
Uninsured
High (≥20 cases/year) 1736 (36.8%) 479 (25.0%) 400 (33.4%) 60 (39.5%) 96 (21.8%) Medium (6–19 cases/year) 1711 (36.2%) 508 (26.5%) 491 (41.0%) 55 (36.2%) 207 (46.9%) Low (≤5 cases/year) 1276 (27.0%) 930 (48.5%) 308 (25.7%) 37 (24.3%) 138 (31.3%) Data presented as numbers and percentages. Distributions differ at p < 0.001 (chi-square test).
SUPPLEMENTARY TABLE IV – Relationship Between Number of Bone Sarcoma Cases Treated Annually and Facility Type
Facility Type ≥20 Cases/Year 6–19 Cases/Year ≤5 Cases/Year
Academic/research 2,597 (93.7%) 2,097 (70.6%) 845 (31.4%)
Comprehensive community 121 (4.4%) 300 (10.1%) 1,234 (45.9%)
Community 0 (0.0%) 0 (0.0%) 241 (9.0%)
Other 53 (1.9%) 575 (19.3%) 369 (13.7%)
Supplementary Fig. 1. Proportions of patients with selected characteristics positively associated with overall survival, by travel distance.
Supplementary Fig. 2. Kaplan-Meier curves comparing overall survival between patients who traveled a short distance (≤10 miles) to a low-volume facility and those who traveled a long distance (≥50 miles) to a high- volume facility, for stage I tumors (A), stage II tumors (B), and stage IV tumors (C).
Supplementary Fig. 3. Kaplan-Meier curves showing overall survival for patients (A) younger than 18 years and (B) 18 years or older who traveled a short distance (≤10 miles) to a low-volume facility or a long distance (≥50 miles) to a high-volume facility.
Supplementary Fig. 4. Proportions of patients who traveled to high-, medium-, and low-volume facilities, by region (p<0.001; chi-square test). *Data for West South Central region excludes the high-volume category because of insufficient data (only one hospital).
