Supplementary table 1: Cut-offs for abnormality in subcategories – 1 SD from the normal mean
Normal
AVG SD
Visual/Executive
/5 4.14 0.87
Naming
/3 2.88 0.36
Recall
/5 3.73 1.27
Attention
/6 5.68 0.63
Language
/3 2.7 0.5
Abstraction
/2 1.83 0.43
Orientation
/6 5.99 0.11
MoCa Total 27.37 2.2
Supplementary table 2: Baseline characteristics of 355 patients with cirrhosis stratified by MoCA ≤24 (means ± SD unless otherwise stated)
Normal Abnormal P Value
N 229 (64.5%) 126 (35.4%)
Patient Characteristics
Age 55.0 ± 9.4 58.5 ± 9.7 0.002
Sex (% men) 63.2% 60.6% 0.66
BMI (scale weight) 28.2 ± 6.0 28.2 ± 5.9 0.92
Weight (kg) 83.8 ± 21 81.1 ± 18.1 0.28
Race (%) 0.04
Caucasian 195 (85.2%) 93 (73.8%)
Aboriginal/Metis 15 (6.6%) 14 (11.1%)
Asian 15 (6.6%) 12 (9.5%)
Black/Hispanic 4 (1.7%) 7 (5.6%)
Ascites (%) 37.9% 37.2% 0.9
Receiving Hepatic Encephalopathy Therapy 33.7% 40.4% 0.24
Etiology (%)
Hepatitis C 32.6% 36.2% 0.39
Alcohol 29.1% 31.9%
Non-Alcoholic Fatty Liver Disease 14.9% 17.0%
Other 23.4% 14.9%
Hospitalized Within 3 Months Pre-assessment (%) 21.9% 25.5% 0.48
HADS Depression Scale Score > 7 28.6% 40.4% 0.03
Albumin 34.8 ± 6.2 34.2 ± 6.7 0.48
Sodium 137.6 ± 3.6 137.4 ± 3.9 0.68
Median Creatinine 75 (60 – 93) 72.5 (61 – 90) 0.85
Hemoglobin 123.7 ± 24 126.9 ± 19.6 0.2
Eq5D Visual Analog Scale 62.3 ± 23 60.4 ± 21.7 0.49
MELD Score 12.5 ± 5 12 ± 4.9 0.41
Child-Pugh Score 7.4 ± 2 7.6 ± 2.1 0.43
Charlson Score
Clinical frailty Scale continuous score Clinical frailty Scale >4
6.1 ± 1.7 3.1 ± 1.02 21 (9.2%)
6.4 ± 1.7 3.8 ± 1.12 29 (23.0%)
0.07 0.001 0.001
Death or Admission at 6 Months (%) 30.7% 45.7% 0.008
Supplementary Table 3: Logistic regression models (stepwise selection) for the prediction of death or hospital admission at 6 months (OR (95% CI))
Variable Death or Hospital Admission at 6 Months
MoCA ≤ 24 and CFS > 4
3.74 (1.51 – 9.27) MoCA ≤ 24 or CFS > 4
1.26 (0.74 – 2.16) Sex (F vs. M)
1.97 (1.18 – 3.3) Hospitalized within 3 Months Pre-
assessment
3.50 (1.98 – 6.19) MELD Score
1.08 (1.02 – 1.14) Sodium
0.86 (0.80 – 0.93)
C statistic 0.77
Akaike Information Criterion 386
Hosmer – Lemeshow Goodness-of-Fit Test [X2 (p-value)]
0.81
*Variables included in the stepwise selection were the MoCA subdomain, age, sex, the presence of ascites, the MELD score, hospitalization within 3 months pre-assessment, serum sodium, a HADS depression score > 7, or receiving any therapy for hepatic encephalopathy.