Online Data Supplement
Title: Effect of admission and discharge times on hospital mortality in patients with sepsis
Journal: Critical Care Medicine
Authors: Xiaoming Zhou
1*, MD, Jie Weng
1*, PHD, Zhe Xu
2, Jinwen Yang
3, B.S.Med , Jiaying Lin
4, MD, Ruonan Hou
1, MD, Zhiliang Zhou
1, MD, Liang Wang
5, PHD, Zhiyi Wang
1,4,6#, PHD, Chan Chen
3#, PHD
Affiliations:
1
Department of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China
2
Department of Emergency Intensive Care Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China
3
Department of Geriatric Medicine, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China
4
Department of General Practice, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou 318001, China
5
Department of Public Health, Robbins College of health and Human Sciences, Baylor University, Waco, TX, USA
6
Center for Health Assessment, Wenzhou Medical University
*Equal contributors
#Correspondence to: Chan Chen: [email protected];
Zhiyi Wang: [email protected]
1
Table of contents
Supplementary
Table 1 Baseline characteristics stratified by ICU admission and discharge time………. Page 3Supplementary Table 2 Odds ratio (OR) for in-hospital mortality by ICU admission time (n = 1341)
………. Page 4Supplementary Table 3 Multivariate regression analysis of transfer out ICU time on in-hospital mortality
………. Page 52
Supplementary
Table 1 Baseline characteristics stratified by ICU admission and discharge timeClinical variable* admitted to ICU (n=1341) discharged alive from ICU (n=1224)
Day (n = 617)
Evening (n = 404)
Night (n = 320)
P value Day (n = 495)
Evening (n = 653)
Night (n = 76) Age, years 70 (64, 75) 71 (62, 76) 70 (62, 76) 0.517 70 (63, 75) 70 (62, 76) 72 (67, 76) Male gender, % 374 (61) 226 (56) 178 (56) 0.204 297 (60) 373 (57) 44 (58) APS III 40 (29, 57) 50 (38, 69) 49 (37, 70) < 0.001 41 (31, 57) 45 (33, 62) 50 (40, 63) SOFA score 5 (4, 7) 6 (3, 9) 5 (4, 8) 0.048 5 (3, 7) 5 (3, 7) 6 (3, 8)
LODS 4 (3, 6) 5 (3, 8) 5 (3, 8) < 0.001 4 (3, 6) 5 (3, 7) 5 (3, 7)
OASIS 32 (27, 38) 35 (29, 43) 35 (28, 41) < 0.001 32 (26, 39) 33 (28, 39) 34 (29, 39) Charlson index 5 (4, 6) 5 (4, 7) 6 (4, 7) 0.004 5 (4, 6) 5 (4, 7) 6 (4, 7) Shock, % 406 (66) 169 (42) 134 (42) < 0.001 288 (58) 306 (47) 31 (41) Ventilation, % 522 (85) 267 (66) 201 (63) < 0.001 379 (77) 455 (70) 47 (62)
CRRT, % 12 (2) 22 (5) 11 (3) 0.01 10 (2) 22 (3) 4 (5)
AKI, % 223 (36) 164 (41) 107 (33) 0.124 169 (34) 210 (32) 25 (33)
Hospital LOS, days 7 (5, 11) 9 (6, 15) 9 (5, 16) < 0.001 7 (5, 12) 8 (5, 13) 12 (6, 18) ICU LOS, days 2 (1, 4) 3 (2, 7) 3 (2, 5) < 0.001 2 (1, 4) 3 (1, 5) 3 (2, 5) Hospital mortality, % 45 (7) 63 (16) 55 (17) < 0.001 13 (3) 22 (3) 11 (14)
ICU mortality, % 36 (6) 47 (12) 34 (11) 0.002 - - -
APS: Acute Physiology Score, SOFA: Sequential Organ Failure Assessment, LODS: Logistic Organ Dysfunction Score, OASIS: Oxford Acute Severity of Illness Score, CRRT: Continuous Renal Replacement Therapy, AKI: Acute Kidney Injury, LOS: length of stay
Data shown as median (interquartile range) or number (percent) as appropriate
3
Supplementary Table 2 Odds ratio (OR) for in-hospital mortality by ICU admission time (n = 1341)
Time of day is defined as “Day” 0800 to 1659, “Evening” 1700 to 2359 and “Night” 0000 to 0759, “Day” is the reference category.
*In addition to severity of illness variable listed in the table, adjusted models include age, gender, Charlson index, mechanical ventilation, and shock
4 Logistic Regression Models
OR (95% CI) p value Unadjusted model
Evening 2.35 (1.57, 3.54) <0.001
Night 2.64 (1.74, 4.03) <0.001
Adjusted for APS III*
Evening 1.76 (1.11, 2.81) 0.017
Night 2.27 (1.41, 3.67) <0.001
Adjusted for SOFA score*
Evening 1.92 (1.23, 3.02) 0.004
Night 2.17 (1.36, 3.48) 0.001
Adjusted for LODS*
Evening 1.82 (1.15, 2.89) 0.011
Night 2.38 (1.48, 3.84) <0.001
Adjusted for OASIS*
Evening 1.96 (1.26, 3.07) 0.003
Night 2.29 (1.44, 3.66) <0.001
Supplementary Table 3 Multivariate regression analysis of transfer out ICU time on in-hospital mortality
Time of day is defined as “Day” 0800 to 1659, “Evening” 1700 to 2359 and “Night” 0000 to 0759, “Day” is the reference category.
5 Multivariate Logistic Regression Models
Variables OR (95% CI) p value
Transfer out ICU time
Day - -
Evening 1.69 (0.35, 8.78) 0.509
Night 0.91 (0.01, 51.3) 0.968
Age 0.97 (0.89, 1.06) 0.626
Male 1.99 (0.40, 1.14) 0.407
APS-III 1.20 (1.14, 1.32) <0.001
Charlson 2.01 (1.34, 3.51) 0.003
