Supplemental Digital Content 5F: Statistical analysis of conclusive results according to histopathological analysis in open group.
CONCLUSIVE OPEN HE
Proportion meta-analysis
Method: Stuart-Ord (inverse double arcsine square root) Stratum Responding Total
1 86 100 Ghosh, 1998
2 76 78 Khan, 2003
3 203 210 Rouzrokh, 2011
4 45 48 Kadowaki, 1979
Stratum Proportion 95% CI (exact)
1 0,86 0,776272 0,921295 Ghosh, 1998
2 0,974359 0,910427 0,99688 Khan, 2003
3 0,966667 0,932529 0,986495 Rouzrokh, 2011
4 0,9375 0,82804 0,986921 Kadowaki, 1979
Stratum Standardized effect Variance % Weights (fixed, random)
1 0,86 0,00995 22,945205 25,79806 Ghosh, 1998
2 0,974359 0,012739 17,922374 24,186289 Khan, 2003
3 0,966667 0,004751 48,059361 29,45849 Rouzrokh, 2011
4 0,9375 0,020619 11,073059 20,557161 Kadowaki, 1979
Fixed effects (inverse variance)
Pooled proportion = 0,942552 (95% CI = 0,918853 to 0,962373) Non-combinability of studies
Cochran Q = 12,388027 (df = 3) P = 0,0062
Moment-based estimate of between studies variance = 0,031896 I2 (inconsistency) = 75,8% (95% CI = 0% to 89,2%)
Random effects (DerSimonian-Laird)
Pooled proportion = 0,936564 (95% CI = 0,878249 to 0,976838) Bias indicators
Begg-Mazumdar: Kendall's tau = -0,666667P = 0,0833 (low power) Egger: bias = -2,488013 (95% CI = -9,877047 to 4,901022) P = 0,2844 Harbord: bias = -2,151726 (92,5% CI = -19,824397 to 15,520945) P = 0,7158
CONCLUSIVE OPEN ACHE
Proportion meta-analysis
Method: Stuart-Ord (inverse double arcsine square root) Stratum Responding Total
1 85 85 Bagdzevicius, 2007
2 40 40 Bagdzevicius, 2011
Stratum Proportion 95% CI (exact)
1 1 0,95753 1 Bagdzevicius, 2007 [97,5% one-sided CI]
2 1 0,911903 1 Bagdzevicius, 2011 [97,5% one-sided CI]
Stratum Standardized effect
Variance % Weights (fixed, random)
1 1 0,011696 67,857143 67,857143 Bagdzevicius, 2007 [97,5%
one-sided CI]
2 1 0,024691 32,142857 32,142857 Bagdzevicius, 2011 [97,5%
one-sided CI]
Fixed effects (inverse variance)
Pooled proportion = 1 (95% CI = 0,977915 to 1) Non-combinability of studies
Cochran Q = 0,065374 (df = 1) P = 0,7982
Moment-based estimate of between studies variance = 0 I2 (inconsistency) = 0% (95% CI = *% to *%)
Random effects (DerSimonian-Laird)
Pooled proportion = 0,996178 (95% CI = 0,977915 to 0,999353) Bias indicators
Begg-Mazumdar: Kendall's <too few strata>*
Egger: bias = <too few strata> (95% CI = * to *) P = * Harbord: bias = * (92,5% CI = * to *) P = *
CONCLUSIVE OPEN HE + ACHE
Proportion meta-analysis
Method: Stuart-Ord (inverse double arcsine square root) Stratum Responding Total
1 72 72 Kurer, 1986
2 46 49 Athow, 1990
Stratum Proportion 95% CI (exact)
1 1 0,950056 1 Kurer, 1986 [97,5% one-sided CI]
2 0,938776 0,831341 0,987192 Athow, 1990 Stratum Standardized
effect
Variance % Weights (fixed, random)
1 1 0,013793 59,42623 51,843582 Kurer, 1986 [97,5% one-
sided CI]
2 0,938776 0,020202 40,57377 48,156418 Athow, 1990
Fixed effects (inverse variance)
Pooled proportion = 0,979624 (95% CI = 0,947154 to 0,997032) Non-combinability of studies
Cochran Q = 5,112996 (df = 1) P = 0,0237
Moment-based estimate of between studies variance = 0,069911 I2 (inconsistency) = 80,4% (95% CI = *% to *%)
Random effects (DerSimonian-Laird)
Pooled proportion = 0,974919 (95% CI = 0,873795 to 0,997967) Bias indicators
Begg-Mazumdar: Kendall's <too few strata>*
Egger: bias = <too few strata> (95% CI = * to *) P = * Harbord: bias = -17,329719 (92,5% CI = * to *) P = *