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Appendix 1. Advanced search procedures and results obtained from data bases

The details of the keywords utilized and the manner of searching is summarized in the tables below. This was adapted from: Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. Journal of Epidemiology & Community Health. 1998 Jun 1;52(6):377-84.

Appendix 1 a. Search strategy for CINAHL data base

# Query Limiters/Expanders Last Run Via Results

S13 S11 AND S12 Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

297

S12 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8

Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

572

S11 S9 OR S10 Expanders - Apply

equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

298,702

S10 pain* Expanders - Apply

equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

280,654

S9 MH Pain+ Expanders - Apply

equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

182,677

S8 (spin## n2 reflex##) Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

290

S7 spin## mediated

reflex## Expanders - Apply

equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

0

S6 RIII Expanders - Apply

equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

61

S5 withdrawal reflex## Expanders - Apply

equivalent subjects Interface - EBSCOhost

Research Databases 123

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Search modes - Boolean/Phrase

Search Screen - Advanced Search

Database - CINAHL with Full Text

S4 flex* reflex## Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

167

S3 (flex* n2 withdrawal

n2 reflex##) Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

20

S2 (nocicept* n2 withdrawal* n2 reflex##)

Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

43

S1 (nocicept* n2 flex* n2

reflex##) Expanders - Apply equivalent subjects Search modes - Boolean/Phrase

Interface - EBSCOhost Research Databases Search Screen - Advanced Search

Database - CINAHL with Full Text

120

Appendix 1 b. Search strategy for PeDRO data base

# PeDRO Search Strategy Results

1 nocicept* flex* reflex* pain* 2

2 nocicept* withdrawal* reflex* pain* 0

3 flex* withdrawal* reflex* pain* 0

4 flex* reflex* pain* 11

5 withdrawal reflex* pain* 0

6 RIII pain* 1

7 spin* mediated reflex* pain* 0

8 spin* reflex* pain* 23

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Appendix 1 c. Search strategy for OVID MEDLINE data bases

# Ovid MEDLINE Search Strategy Results

1 (nocicept* adj2 flex* adj2 reflex??).tw,kf. 394

2 (nocicept* adj2 withdrawal* adj2 reflex??).tw,kf. 186

3 (flex* adj2 withdrawal adj2 reflex??).tw,kf. 106

4 flex* reflex??.tw,kf. 1182

5 withdrawal reflex??.tw,kf. 1246

6 RIII.tw,kf. 1252

7 spin?? mediated reflex??.tw,kf. 4

8 (spin?? adj2 reflex??).tw,kf. 2751

9 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 6038

10 exp pain/ 380804

11 pain*.tw,kf. 658807

12 10 or 11 803154

13 9 and 12 1255

14 limit 13 to english language 1177

15 14 not (exp animals/ not exp humans/) 612

Appendix 1 d. Search strategy for Cochrane Clinical Answers, Cochrane Central Register for Clinical Trials, and Cochrane Database for Systematic Reviews

# Cochrane Databases Search Strategy Results

1 (nocicept* adj2 flex* adj2 reflex??).ab,hw,kw,sh,ti,tx. 113

2 (nocicept* adj2 withdrawal* adj2 reflex??).ab,hw,kw,sh,ti,tx. 36

3 (flex* adj2 withdrawal adj2 reflex??).ab,hw,kw,sh,ti,tx. 3

4 flex* reflex??.ab,hw,kw,sh,ti,tx. 181

5 withdrawal reflex??.ab,hw,kw,sh,ti,tx. 81

6 RIII.ab,hw,kw,sh,ti,tx. 126

7 spin?? mediated reflex??.ab,hw,kw,sh,ti,tx. 1

8 (spin?? adj2 reflex??).ab,hw,kw,sh,ti,tx. 141

9 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 475

10 exp pain/ 46179

11 pain*.ab,hw,kw,sh,ti,tx. 170328

12 10 or 11 177691

13 9 and 12 233

14 limit 13 to English language [Limit not valid in CCA, CDSR; records were retained] 186

15 14 not (exp animals/ not exp humans/) 175

16 limit 15 to yr="2010 -Current" 96

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Appendix 1 e. Search strategy for Embase data base

# Searches Results

1 (nocicept* adj2 flex* adj2 reflex??).tw. 501

2 (nocicept* adj2 withdrawal* adj2 reflex??).tw. 231

3 (flex* adj2 withdrawal adj2 reflex??).tw. 105

4 flex* reflex??.tw. 1295

5 withdrawal reflex??.tw. 1447

6 RIII.tw. 885

7 spin?? mediated reflex??.tw. 4

8 (spin?? adj2 reflex??).tw. 2975

9 or/1-8 6179

10 pain/ 297671

11 exp musculoskeletal pain/ 142365

12 chronic pain/ 57960

13 pain*.tw. 959251

14 or/10-13 1077604

15 9 and 14 1421

16 limit 15 to english language 1325

17 limit 16 to medline 98

18 16 not 17 1227

19 18 not ((exp animals/ or exp animal experimentation/ or nonhuman/) not exp human/) 740

20 limit 19 to yr="2010 -Current" 418

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