Supplemental Digital Content, Table S1. Unadjusted associations (Pearson correlations) between baseline FKBP5 expression and cognition as a function of HIV-serostatus (women with HIV [WWH], HIV-uninfected [HIV-]) and Age (younger, <40 years of age, older, >50 years of age).
Younger Older
Outcomes
HIV- r
WWH r
HIV- r
WWH r Primary
Verbal memory 0.07 -0.21 0.07 -0.21
Attention/working memory 0.32* 0.12 -0.14 0.51**
Secondary
Verbal learning -0.09 -0.24 0.09 -0.04
Executive function 0.07 0.02 -0.09 -0.03
Speed 0.11 0.01 0.13 0.31T
Fluency -0.05 0.10 -0.26 0.09
Motor skills 0.08 -0.23 -0.10 0.04
Note. ***P<0.001; **P<0.01; *P<0.05; T P=0.05
Supplemental Digital Content, Table S2. TNF-alpha concentrations (pg/ml) at baseline (unstimulated), following LPS and LPS+Dex treatments stratified by study group (HIV-
serostatus: women with HIV [WWH], HIV-uninfected [HIV-] and Age: younger, <40 years of age, older, >50 years of age).
HIV-, Age<40 (N=40)
HIV-, Age>50 (N=40)
HIV+, Age<40 (N=40)
HIV+, Age>50 (N=40)
Total
(N=160) p value
Baseline 0.0371
Median 9.63 11.11 21.65 11.16 11.93
IQR 14.38 43.40 154.74 82.03 53.08
N* 36 32 35 35 138
LPS 0.8451
Median 3685.92 3259.19 3148.03 3055.60 3352.34
IQR 3619.60 3762.10 5149.99 3868.32 4128.67
N* 38 38 37 38 151
LPS+Dex 0.9371
Median 1459.09 1161.28 1480.55 1258.74 1372.41
IQR 1496.15 1408.43 2493.30 1521.50 1694.09
N* 35 38 37 38 148
1. Kruskal-Wallis rank sum test
* 3-8 missing values/group due to non-detectable concentrations or not enough sample to run assay.