Supplementary TABLE 2 Adjusted hazards ratios (includes APOE*4) for anticholinergic drug use on developing dementia#
Model S4 Model S5 Model S6
Variable HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value Age 1.1 (1.1, 1.2) <0.001 1.1 (1.1, 1.2) <0.001 1.1 (1.1, 1.2) <0.001 Female 1.1 (0.7, 1.6) 0.678 1.1 (0.7, 1.6) 0.689 1.1 (0.7, 1.6) 0.681 Education
< high school Reference Reference Reference
= high school 0.7 (0.4, 1.1) 0.108 0.7 (0.4, 1.1) 0.111 0.7 (0.4, 1.1) 0.111
> high school 0.6 (0.4, 1.0) 0.037 0.6 (0.4, 1.0) 0.038 0.6 (0.4, 1.0) 0.039 Total number of
prescription medications
<3 Reference Reference Reference
3-6 1.0 (0.6, 1.6) 0.968 1.0 (0.6, 1.6) 0.979 1.0 (0.6, 1.6) 0.981 >6 1.1 (0.6, 2.0) 0.735 1.1 (0.6, 2.0) 0.783 1.1 (0.6, 2.0) 0.799 APOE*4 3.2 (1.6, 6.4) 0.001 3.2 (1.6, 6.4) 0.001 3.2 (1.6, 6.4) 0.001 any anticholinergic
drug use
1.1 (0.6, 2.0) 0.722 Interaction term:
APOE*4 and any anticholinergic drug use
0.7 (0.3, 1.6) 0.394
Total ACR score
0 Reference
1-3 1.1 (0.6, 2.0) 0.760
>3 1.2 (0.6, 2.4) 0.683
Interaction term:
APOE*4 and
total ACR score 1-3 0.7 (0.3, 1.7) 0.439
APOE*4 and
total ACR score >3 0.7 (0.2, 2.0) 0.483
Total number of anticholinergic drugs
0 Reference
1-2 1.1 (0.6, 2.0) 0.743
>2 1.1 (0.5, 2.4) 0.714
Interaction term:
APOE*4 and total number of anticholinergic drugs 1-2
0.7 (0.3, 1.7) 0.431
APOE*4 and total number of anticholinergic drugs >2
0.7 (0.2, 2.0) 0.499
Abbreviations: HR, hazard ratio; CI, confidence interval.
#Dementia was defined as clinical dementia rating (CDR) score 1.
Models S4, S5, S6 used any anticholinergic drug use, total ACR score, total number of anticholinergic drugs as the main predictor, respectively. Interaction term between APOE*4 and any anticholinergic drug use, total ACR score, total number of anticholinergic drugs was included in each model, respectively.
