Patient Group Complication Grading (minor or major)
Infectious or non- infectious complication 5 mg/kg,
Standard dosing interval (n=3)
Bilateral subsegmental PE Minor Non-infectious
Bacteremia Minor Infectious
10 mg/kg, Single inpatient dose (n=9)
Wound infection Minor Infectious
Intra-abdominal collection requiring IR drainage
Major Infectious
Ileus requiring nasogastric tube placement Minor Non-infectious
C. difficile infection Minor Infectious
Ileus requiring readmission, resolved without intervention
Minor Non-infectious
1. Aspergillus pneumonia 2. Adrenal insufficiency 3. Multidrug-resistant UTI 4. Encephalopathy
5. Urinary retention treated with straight catheterization
6. TPN for malnutrition
All minor 1. Infectious 2. Non-infectious 3. Infectious 4. Non-infectious 5. Non-infectious 6. Non-infectious
1. Rectal stump leak and intra-abdominal collections of Candida infection, requiring IR drainage
2. Encephalopathy requiring ICU stay 3. Ileus requiring nasogastric tube placement
4. C. difficile infection 5. Hypertension 6. Hypernatremia
7. Wide-complex tachycardia 8. Bilateral DVT
1, 2. Major 3-8. Minor
1. Infectious 2. Non-infectious 3. Non-infectious 4. Infectious 5. Non-infectious 6. Non-infectious 7. Non-infectious 8. Non-infectious
Transfusion for postoperative anemia Minor Non-infectious 1. Rectal stump leak treated with
antibiotics
2. TPN for malnutrition
3. Urinary retention treated with straight catheterization
Minor 1. Infectious
2. Non-infectious 3. Non-infectious
10 mg/kg, Multiple inpatient doses (n=10)
ICU admission for postoperative
hypotension improved with antibiotics and IV steroid administration
Major Non-infectious
Portal venous thrombus Minor Non-infectious
Supplemental Table 1. Complications for patients requiring colectomy within 90 days of infliximab rescue therapy. N next to each category denotes the number of patients in that group who received colectomy within 90 days of infliximab rescue therapy. A minor complication was defined as Clavien- Dindo classification 2 or lower, with a major complication defined as 3 or higher. VTE: venous thromboembolism. TPN: total parenteral nutrition. DVT: deep venous thrombosis. PE: pulmonary embolism. IR: interventional radiology. ICU: intensive care unit. UTI: urinary tract infection.
Each row above denotes the complications for one of the patients within that group. The number of rows is less than the total number of patients in the groups because some patients had no complications.