Deep learning for automatic bone marrow apparent diffusion coefficient measurements from whole-body MRI in patients with multiple myeloma – a retrospective multicenter study
- Supplemental Digital Content 4 -
Supplementary Table 2. Agreement between automatically extracted ADC values and manual measurements by radiologists for data set I.
Comparison bone
bias (absolute)*
bias (relative to mean)
coefficient of variation in %
lower and upper limit of agreement Reader 1 vs. nnU-Net
right pelvis 51 8.8% 17.6% -203, 305
left pelvis 15 2.7% 17.9% -243, 273
sacral bone -56 -10.3% 16.1% -273,162
Reader 2 vs. nnU-Net
right pelvis 2 0.4% 17.0% -235, 238
left pelvis -8 -1.5% 16.0% -222, 207
sacral bone -79 -14.9% 12.8% -234, 77
Reader 1 vs. Reader 2
right pelvis 50 8.7% % -146, 247
left pelvis 24 4.3% % -171, 219
sacral bone 23 4.6% % -197, 244
* absolute ADC-values are given in 10-6 mm2/s
1
Supplementary Table 3. Agreement between automatically extracted ADC values and manual measurements by radiologists for data set II.
Comparison bone
bias (absolute)*
bias (relative to mean)
coefficient of variation in %
lower and upper limit of agreement Reader 1 vs. nnU-Net
right pelvis 67 12.7% 18.7% -136, 271
left pelvis 14 2.9% 22.5% -197, 225
sacral bone -63 -13.4% 22.3% -235, 108
Reader 2 vs. nnU-Net
right pelvis 21 4.2% 15.7% -152, 195
left pelvis 16 3.3% 21.3% -189, 222
sacral bone -61 -13.0% 18.8% -204, 83
Reader 1 vs. Reader 2
right pelvis 46 8.6% % -176, 267
left pelvis -2 -0.4% % -178, 174
sacral bone -3 -0.7% % -193, 188
* absolute ADC-values are given in 10-6 mm2/s
2
Supplementary Table 4. Agreement between automatically extracted ADC values and manual measurements by radiologists for data set III.
Comparison bone
bias (absolute)*
bias (relative to mean)
coefficient of variation in %
lower and upper limit of agreement Reader 1 vs. nnU-Net
right pelvis -14
-3.7% 51.5% -240, 213
left pelvis -23
-6.5% 43.2% -183, 137
sacral bone -46
-13.4% 43.2% -168, 76
Reader 2 vs. nnU-Net
right pelvis 14
3.6% 44.0% -159, 187
left pelvis -10
-2.8% 40.2% -169, 150
sacral bone -27
-7.8% 42.2% -176, 123
Reader 1 vs. Reader 2
right pelvis -32
-8.1% 53.4% -192, 128
left pelvis -10
-2.8% 47.0% -160, 140
sacral bone -12
-3.5% 48.0% -154, 130
* absolute ADC-values are given in 10-6 mm2/s
