Supplemental Table 1. Characteristics and Outcomes by Motoric Subtype of Delirium
Characteristic* Hyperactive Delirium N=185
Hypoactive Delirium N=733
Age at enrollment, years 64 (55-74) 63 (54-72)
Male sex (%) 73% 59%
Education, years 12 (12-14) 12 (12-14)
AHRQ Socioeconomic (AHRQ SES) Index
50 (47-53) 50 (47-53)
IQCODE-SF at enrollment 3.0 (3.0-3.2) 3.0 (3.0-3.2)
Katz ADL at enrollment 0 (0-1) 0 (0-1)
FAQ at enrollment 0 (0-3) 0 (0-3)
Clinical Frailty Scale at enrollment (%)
Very fit 2% 3%
Well 16% 13%
Well, treated comorbid disease 33% 34%
Apparently vulnerable 27% 21%
Mildly frail 9% 12%
Moderately frail 11% 14%
Severely frail 2% 3%
Charlson comorbidity index 2 (1-4) 2 (1-4)
Framingham stroke risk 10 (7-15) 10 (6-15)
SOFA score at enrollment 9 (7-11) 9 (7-12)
APACHE II at ICU admission 24 (19-30) 25 (19-31)
ICU type (%)
Medical 61% 66%
Surgical 39% 34%
Severe sepsis on enrollment (%) 61% 57%
Delirium duration, days 6 (4-12) 4 (2-7)
Coma (%) 82% 72%
Duration among exposed, days 4 (2-7) 3 (2-6)
ICU length of stay, days 10.0 (4.9-18.6) 7.0 (3.8-14.1)
In-hospital mortality (%) 22% 20%
12-month mortality (%) 41% 41%
*Median (interquartile range) unless specified
Participant characteristics and mortality outcomes of the cohort are displayed stratified by motoric subtype of delirium. Summary statistics are reported for non-missing values. Percents may not total 100 because of rounding. We defined motoric subtype presentation according to the corresponding RASS score on assessments when the CAM-ICU was positive. We considered hypoactive delirium present if the corresponding RASS score was 0. We considered
hyperactive delirium present if the corresponding RASS score was > 0. Because we considered each delirium assessment as independent for these motoric subtypes, a patient could have both hypoactive and hyperactive delirium on a given day. Thus, the groups presented in the table are not mutually exclusive.
Abbreviations: ADL, activities of daily living; APACHE, Acute Physiology and Chronic Health Evaluation; FAQ, Functional Activities Questionnaire; ICU, intensive care unit; IQCODE-SF, Short Form Informant Questionnaire on Cognitive Decline in the Elderly; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; SOFA, Sequential Organ Failure Assessment.
