Supplemental Table 1. Combined Demographics, Incidence Rates, APCs, and Rate Ratios by Sex for Patients with CIS and SCC, SEER 9 2010-2014.
No. of Patients Incidence Rate* 95% CI† APC 95% CI† No. of Patients Incidence Rate* 95% CI† APC 95% CI† Incidence Rate Ratio*¥ 95% CI†
1,235 1.617 1.526 - 1.712 3.470 -4.857 - 12.526 2,332 3.481 3.339 - 3.627 -3.744 -7.267 - -0.088 2.152 2.005 - 2.311
Age Groups
20-29 23 0.225 0.142 - 0.337 20.727 -19.385 - 80.797 150 1.418 1.200 - 1.664 0.273 -16.671 - 20.661 6.309 4.048 - 10.259
30-39 73 0.735 0.576 - 0.925 9.934 -10.803 - 35.492 329 3.345 2.992 - 3.728 -6.680 -13.237 - 0.373 4.551 3.519 - 5.955
40-49 269 2.564 2.266 - 2.891 -5.199 -20.759 - 13.417 791 7.720 7.190 - 8.278 -6.745 -11.092 - -2.187 3.010 2.617 - 3.471
50-59 582 5.562 5.118 - 6.035 4.073 -3.425 - 12.153 818 8.269 7.711 - 8.858 0.130 -3.384 - 3.772 1.487 1.335 - 1.657
60-64 288 6.663 5.915 - 7.478 11.690 -6.691 - 33.691 240 6.022 5.284 - 6.834 0.438 -16.003 - 20.097 0.904 0.758 - 1.076
Race§
White 972 1.690 1.582 - 1.803 3.003 -5.223 - 11.942 1,715 3.364 3.203 - 3.531 -6.588 -10.480 - -2.528 1.991 1.834 - 2.160
Black 183 2.001 1.720 - 2.315 8.551 1.462 - 16.136 386 4.976 4.488 - 5.500 10.547 -7.066 - 31.498 2.486 2.077 - 2.984
Other∂ 45 0.432 0.314 - 0.580 4.576 -19.227 - 35.395 106 1.231 1.007 - 1.490 0.866 -19.638 - 26.601 2.852 1.984 - 4.147
408 0.571 0.516 - 0.631 3.308 -15.017 - 25.585 1,708 2.598 2.475 - 2.727 -6.800 -12.006 - -1.286 4.547 4.069 - 5.089
Age Groups
20-29 20 0.195 0.119 - 0.302 15.891 -24.284 - 77.385 144 1.361 1.148 - 1.603 -3.099 -18.617 - 15.379 6.969 4.345 - 11.752
30-39 55 0.551 0.414 - 0.718 11.675 -10.707 - 39.666 293 2.974 2.641 - 3.336 -7.880 -14.41 - -0.852 5.399 4.031 - 7.349
40-49 106 1.017 0.832 - 1.231 -6.003 -32.917 - 31.709 597 5.848 5.387 - 6.338 -9.736 -16.282 - -2.679 5.751 4.668 - 7.144
50-59 161 1.568 1.334 - 1.830 1.526 -26.806 - 40.825 534 5.417 4.966 - 5.898 -2.771 -8.64 - 3.476 3.456 2.890 - 4.151
60-64 66 1.527 1.181 - 1.942 15.959 -13.772 - 55.942 137 3.438 2.886 - 4.06 -5.498 -30.911 - 29.261 2.252 1.667 - 3.068
Race§
White 273 0.513 0.452 - 0.580 1.673 -18.345 - 26.598 1,266 2.558 2.416 - 2.706 -9.766 -13.634 - -5.725 4.986 4.353 - 5.726
Black 86 0.947 0.756 - 1.171 13.287 -0.774 - 29.341 243 3.108 2.726 - 3.526 12.019 -8.285 - 36.819 3.282 2.552 - 4.253
Other∂ 20 0.203 0.124 - 0.316 3.732 -27.432 - 48.280 80 0.931 0.737 - 1.159 -0.959 -25.441 - 31.563 4.575 2.759 - 7.914
827 1.046 0.974 - 1.121 3.589 -3.252 - 10.914 624 0.882 0.813 - 0.956 5.761 -2.505 - 14.728 0.844 0.758 - 0.939
Age Groups
20-29 3 0.029 0.006 - 0.086 - - 6 0.057 0.021 - 0.124 - - 1.928 0.411 - 11.931
30-39 18 0.184 0.109 - 0.291 4.965 -15.817 - 30.877 36 0.372 0.260 - 0.515 3.463 -2.962 - 10.313 2.017 1.115 - 3.780
40-49 163 1.548 1.319 - 1.805 -5.129 -17.831 - 9.536 194 1.872 1.617 - 2.155 2.928 -10.36 - 18.187 1.209 0.976 - 1.499
50-59 421 3.995 3.621 - 4.397 5.248 -4.015 - 15.406 284 2.852 2.529 - 3.205 5.929 -3.555 - 16.347 0.714 0.612 - 0.832
60-64 222 5.136 4.482 - 5.858 10.180 -7.175 - 30.779 103 2.584 2.110 - 3.134 8.238 -4.752 - 23.001 0.503 0.394 - 0.638
Race§
White 699 1.177 1.089 - 1.271 3.633 -3.197 - 10.943 449 0.806 0.732 - 0.887 4.335 -12.444 - 24.33 0.685 0.605 - 0.775
Black 97 1.054 0.854 - 1.288 4.386 -0.460 - 9.469 143 1.868 1.573 - 2.201 9.039 -20.492 - 49.537 1.772 1.357 - 2.319
Other∂ 25 0.228 0.147 - 0.340 3.975 -31.28 - 57.317 26 0.300 0.196 - 0.440 3.551 -27.794 - 48.504 1.316 0.723 - 2.380
SCC Stage‡
Localized 411 0.521 0.470 - 0.575 6.457 -3.604 - 17.568 349 0.498 0.446 - 0.554 2.256 -13.772 - 21.264 0.957 0.824 - 1.109
Regional 284 0.354 0.313 - 0.399 0.061 -6.312 - 6.868 187 0.257 0.221 - 0.298 13.273 3.530 - 23.933 0.727 0.598 - 0.880
Distant 98 0.126 0.101 - 0.154 -3.634 -32.119 - 36.802 62 0.090 0.069 - 0.116 -1.108 -9.838 - 8.469 0.717 0.509 - 1.002
Men Women
CIS - In Situ
SCC - Invasive Dz SEER 9: 2010-2014 Characteristics All Patients: CIS + SCC
Abbreviations: APC, annual percent change; CIS, anal squamous cell carcinoma in situ; SCC, invasive anal squamous cell carcinoma.
*Rates are per 100,000 and age adjusted to the 2000 US standard population for collective age groups.
†CIs (Tiwari modification) are 95% for rates, APC, and rate ratios.
¥Men vs Women.
Supplemental Table 1 continued. Combined Demographics, Incidence Rates, APCs, and Rate Ratios by Sex for Patients with CIS and SCC, SEER 9 2010-2014.
‡SCC stage was also classified as Unstaged and Blank according to SEER historic stage A; these patients were excluded from SCC stage analyses.
§Race was also classified as Unknown; these patients were excluded from race analyses.
∂Other consists of American Indian, Alaska Native, Asian, and Pacific Islander.
-Data not available.
Supplemental Table 1 continued. Combined Demographics, Incidence Rates, APCs, and Rate Ratios by Sex for Patients with CIS and SCC, SEER 9 2010-2014.
SEER 9: 2010- 2014
Women Men
Characteristics No. of Patient s
Inciden ce Rate*
95%
CI†
AP C
95%
CI†
No. of Patient s
Inciden ce Rate*
95%
CI†
AP C
95%
CI†
Incidence Rate Ratio*¥
95%
CI†
All Patients:
CIS + SCC
1,235 1.617 1.526 - 1.712
3.4 70
-4.857 - 12.526
2,332 3.481 3.339 - 3.627
- 3.7 44
-7.267 - -0.088
2.152 2.005 - 2.311 Age
Groups
20-29 23 0.225 0.142
- 0.337
20.
72 7
-19.385 - 80.797
150 1.418 1.200
- 1.664
0.2 73
-16.671 - 20.661
6.309 4.048 - 10.259
30-39 73 0.735 0.576
- 0.925
9.9 34
-10.803 - 35.492
329 3.345 2.992
- 3.728
- 6.6 80
-13.237 - 0.373
4.551 3.519 - 5.955
40-49 269 2.564 2.266
-
- 5.1
-20.759 - 13.417
791 7.720 7.190
-
- 6.7
-11.092 - -2.187
3.010 2.617
-
2.891 99 8.278 45 3.471
50-59 582 5.562 5.118
- 6.035
4.0 73
-3.425 - 12.153
818 8.269 7.711
- 8.858
0.1 30
-3.384 - 3.772
1.487 1.335 - 1.657
60-64 288 6.663 5.915
- 7.478
11.
69 0
-6.691 - 33.691
240 6.022 5.284
- 6.834
0.4 38
-16.003 - 20.097
0.904 0.758 - 1.076 Race§
White 972 1.690 1.582
- 1.803
3.0 03
-5.223 - 11.942
1,715 3.364 3.203 - 3.531
- 6.5 88
-10.480 - -2.528
1.991 1.834 - 2.160
Black 183 2.001 1.720
- 2.315
8.5 51
1.462 - 16.136
386 4.976 4.488
- 5.500
10.
54 7
-7.066 - 31.498
2.486 2.077 - 2.984 Other
∂
45 0.432 0.314
- 0.580
4.5 76
-19.227 - 35.395
106 1.231 1.007
- 1.490
0.8 66
-19.638 - 26.601
2.852 1.984 - 4.147 CIS - In Situ 408 0.571 0.516
- 0.631
3.3 08
-15.017 - 25.585
1,708 2.598 2.475 - 2.727
- 6.8 00
-12.006 - -1.286
4.547 4.069
-
5.089
Age
Groups
20-29 20 0.195 0.119
- 0.302
15.
89 1
-24.284 - 77.385
144 1.361 1.148
- 1.603
- 3.0 99
-18.617 - 15.379
6.969 4.345 - 11.752
30-39 55 0.551 0.414
- 0.718
11.
67 5
-10.707 - 39.666
293 2.974 2.641
- 3.336
- 7.8 80
-14.41 - -0.852
5.399 4.031 - 7.349
40-49 106 1.017 0.832
- 1.231
- 6.0 03
-32.917 - 31.709
597 5.848 5.387
- 6.338
- 9.7 36
-16.282 - -2.679
5.751 4.668 - 7.144
50-59 161 1.568 1.334
- 1.830
1.5 26
-26.806 - 40.825
534 5.417 4.966
- 5.898
- 2.7 71
-8.64 - 3.476
3.456 2.890 - 4.151
60-64 66 1.527 1.181
- 1.942
15.
95 9
-13.772 - 55.942
137 3.438 2.886
- 4.06 - 5.4 98
-30.911 - 29.261
2.252 1.667 - 3.068 Race§
White 273 0.513 0.452
- 0.580
1.6 73
-18.345 - 26.598
1,266 2.558 2.416 - 2.706
- 9.7 66
-13.634 - -5.725
4.986 4.353
-
5.726
Black 86 0.947 0.756 13. -0.774 - 243 3.108 2.726 12. -8.285 - 3.282 2.552
- 1.171
28 7
29.341 -
3.526 01 9
36.819 -
4.253 Other
∂
20 0.203 0.124
- 0.316
3.7 32
-27.432 - 48.280
80 0.931 0.737
- 1.159
- 0.9 59
-25.441 - 31.563
4.575 2.759 - 7.914 SCC - Invasive
Dz
827 1.046 0.974
- 1.121
3.5 89
-3.252 - 10.914
624 0.882 0.813
- 0.956
5.7 61
-2.505 - 14.728
0.844 0.758 - 0.939 Age
Groups
20-29 3 0.029 0.006
- 0.086
- - 6 0.057 0.021
- 0.124
- - 1.928 0.411
- 11.931
30-39 18 0.184 0.109
- 0.291
4.9 65
-15.817 - 30.877
36 0.372 0.260
- 0.515
3.4 63
-2.962 - 10.313
2.017 1.115 - 3.780
40-49 163 1.548 1.319
- 1.805
- 5.1 29
-17.831 - 9.536
194 1.872 1.617
- 2.155
2.9 28
-10.36 - 18.187
1.209 0.976
-
1.499
50-59 421 3.995 3.621 5.2 -4.015 - 284 2.852 2.529 5.9 -3.555 - 0.714 0.612
- 4.397
48 15.406 -
3.205
29 16.347 -
0.832
60-64 222 5.136 4.482
- 5.858
10.
18 0
-7.175 - 30.779
103 2.584 2.110
- 3.134
8.2 38
-4.752 - 23.001
0.503 0.394 - 0.638 Race§
White 699 1.177 1.089
- 1.271
3.6 33
-3.197 - 10.943
449 0.806 0.732
- 0.887
4.3 35
-12.444 - 24.33
0.685 0.605 - 0.775
Black 97 1.054 0.854
- 1.288
4.3 86
-0.460 - 9.469
143 1.868 1.573
- 2.201
9.0 39
-20.492 - 49.537
1.772 1.357 - 2.319 Other
∂
25 0.228 0.147
- 0.340
3.9 75
-31.28 - 57.317
26 0.300 0.196
- 0.440
3.5 51
-27.794 - 48.504
1.316 0.723 - 2.380 SCC
Stage‡
Local ized
411 0.521 0.470
- 0.575
6.4 57
-3.604 - 17.568
349 0.498 0.446
- 0.554
2.2 56
-13.772 - 21.264
0.957 0.824
-
1.109
Regio 284 0.354 0.313 0.0 -6.312 - 187 0.257 0.221 13. 3.530 - 0.727 0.598
nal - 0.399
61 6.868 -
0.298 27 3
23.933 -
0.880 Dista
nt
98 0.126 0.101
- 0.154
- 3.6 34
-32.119 - 36.802
62 0.090 0.069
- 0.116
- 1.1 08
-9.838 - 8.469
0.717 0.509 - 1.002
Supplemental Table 2. Combined Demographics, Incidence Rates, APCs, and Rate Ratios by Sex and Race for Patients with CIS and SCC, SEER 9 2010-2014.
No. of Patients Incidence Rate* 95% CI† APC 95% CI† No. of Patients Incidence Rate* 95% CI† APC 95% CI† Incidence Rate Ratio*¥ 95% CI†
1,715 3.364 3.203 - 3.531 -6.588 -10.480 - -2.528 386 4.976 4.488 - 5.500 10.547 -7.066 - 31.498 1.479 1.319 - 1.654
Age Groups
20-29 84 1.111 0.886 - 1.376 -10.212 -29.393 - 14.180 46 3.164 2.315 - 4.222 40.469 -2.265 - 101.887 2.848 1.9419 - 41.129
30-39 211 3.002 2.609 - 3.438 -15.588 -20.467 - '-10.409 69 5.515 4.287 - 6.986 32.837 9.226 - 61.553 1.837 1.3774 2.424
40-49 562 7.402 6.800 - 8.042 -10.876 -19.483 - -1.350 142 11.376 9.580 - 13.411 9.386 -8.420 - 30.655 1.537 1.269 - 1.851
50-59 651 8.486 7.844 - 9.166 1.891 -5.112 - 9.411 111 10.418 8.568 - 12.546 -3.523 -15.839 - 10.596 1.228 0.9944 - 1.5038
60-64 206 6.511 5.652 - 7.463 3.176 -12.268 - 21.339 17 4.541 2.646 - 7.271 -14.636 -29.812 - 3.820 0.698 0.3986 - 1.144
1,266 2.558 2.416 - 2.706 -9.766 -13.634 - -5.725 243 3.108 2.726 - 3.526 12.019 -8.285 - 36.819 1.215 1.053 - 1.396
449 0.806 0.732 - 0.887 4.335 -12.444 - 24.330 143 1.868 1.573 - 2.201 9.039 -20.492 - 49.537 2.317 1.902 - 2.806
SCC Stage‡
Localized 253 0.462 0.405 - 0.524 2.224 -21.241 - 32.680 78 1.022 0.807 - 1.275 0.452 -24.441 - 33.546 2.213 1.689 - 2.867 Regional 139 0.240 0.201 - 0.285 9.929 -9.525 - 33.566 41 0.536 0.384 - 0.726 29.868 -30.526 - 142.760 2.232 1.528 - 3.184
Distant 41 0.077 0.055 - 0.105 -7.488 -17.377 - 3.585 16 0.204 0.117 - 0.331 10.367 -16.501 - 45.882 2.660 1.382 - 4.852
972 1.690 1.582 - 1.803 3.003 -5.223 - 11.942 183 2.001 1.720 - 2.315 8.551 1.462 - 16.136 1.184 1.004 - 1.390
Age Groups
20-29 8 0.112 0.048 - 0.221 5.005 -25.056 - 47.124 11 0.726 0.362 - 1.298 - - 6.474 2.3669 - 18.526
30-39 52 0.758 0.565 - 0.995 12.280 -21.782 - 61.175 13 0.918 0.488 - 1.570 14.110 -32.261 - 92.226 1.212 0.6039 - 2.258
40-49 188 2.508 2.161 - 2.895 -6.613 -24.743 - 15.885 59 4.097 3.118 - 5.287 4.393 -10.003 - 21.091 1.634 1.1973 - 2.201
50-59 478 6.049 5.516 - 6.619 2.993 -2.331 - 8.606 77 6.244 4.926 - 7.806 8.010 -22.256 - 50.058 1.032 0.8002 - 1.316
60-64 246 7.424 6.525 - 8.412 12.968 -4.191 - 33.202 23 4.866 3.085 - 7.302 0.584 -45.028 - 84.040 0.656 0.4078 - 1.006
273 0.513 0.452 - 0.580 1.673 -18.345 - 26.598 86 0.947 0.756 - 1.171 13.287 -0.774 - 29.341 1.846 1.426 - 2.367
699 1.177 1.089 - 1.271 3.633 -3.197 - 10.943 97 1.054 0.854 - 1.288 4.386 -0.460 - 9.469 0.896 0.715 - 1.111
SCC Stage‡
Localized 353 0.592 0.530 - 0.659 6.780 -4.150 - 18.956 48 0.529 0.389 - 0.702 6.151 -3.785 - 17.114 0.894 0.644 - 1.214
Regional 244 0.410 0.359 - 0.467 0.625 -9.933 - 12.422 26 0.273 0.178 - 0.401 -8.444 -35.329 - 29.617 0.665 0.424 - 1.003
Distant 74 0.124 0.097 - 0.158 -9.187 -38.868 - 34.906 20 0.222 0.135 - 0.343 14.259 -28.786 - 83.322 1.784 1.021 - 2.970
Black
SCC - Invasive Dz SCC - Invasive Dz
White
CIS - In Situ Female: CIS + SCC SEER 9: 2010-2014 Characteristics Male: CIS + SCC
CIS - In Situ