Table s1: Characteristics of selected studies
Author, year
reference Study design
Bilateral absent SSEP (N)
Good outcome and bilateral absent SSEP
(N)
Targeted Temperature Management
OHCA or IHCA
Predictors reported
Definition of poor outcome
Timing outcome assessment
FPR (%)
SSEP timing (from ROSC)
9 case report 1 1 TH NA CR, PLR, MR,
SSEP
ambulation with walker
22 days - 49h
37 case report 1 1 no TTM OHCA CT, EEG, PLR,
MR, SSEP
Barthel 90/100 and EuroQOoL
65%
3 years - day 3 and day 9
38 retrospective chart review
18 0** TH NA EEG, PLR, MR,
myoclonus, SSEP
GOS 1-3 3 months 0 after rewarming
10 prospective cohort 13 0 TH NA SSEP GOS 1-2 1 month 0 hypothermia and
normothermia
7 prospective cohort 43 3 TH mixed CR, MR, NSE,
PLR, SSEP
GOS 1-3 6 months 3 hypothermia and
normothermia 39 retrospective chart
review
10 0 TH OHCA CT, MRI,
myoclonus, PLR, SSEP
CPC 3-5 hospital
discharge
0 within 72h from start of normothermia
35 prospective cohort 7 0 TH mixed EEG, SSEP CPC 3-5 6 months 0 during the first 5 days
of the ICU stay or before discharge from
the ICU
12 case report 1 1 TH OHCA MR, PLR, SSEP normal
neurological exam
few months - 84h and day 13
36 prospective cohort 14 0 TH mixed CR, EEG, MRI,
NSE, PLR, SSEP
CPC 4-5 6 months 0 72 hours after start of normothermia
11 retrospective chart 34 0 TH OHCA CR, EEG, MR, CPC 4-5 6 months 0 48-72h
review myoclonus, PLR, SSEP
13 randomized
controlled trial
75 1 TH and TTM 36°C mixed CR, CT, EEG,
MR, MRI, PLR, SSEP
CPC 3-5 6 months 2.6 69-120h
14 retrospective chart review
12 0 TH OHCA CT, EEG, MR,
SSEP
CPC 3-5 hospital
discharge
0 normothermia
15 prospective cohort 41 0 TH NA EEG, MR, NSE,
PLR, SSEP
CPC 4-5 ICU discharge 0 24-96h
16 prospective cohort 2 0 TH* mixed CR, CT, EEG,
MR, myoclonus, NSE, PLR, SSEP
CPC 3-5 hospital
discharge
0 24-72h
17 retrospective chart review
31 0 TH mixed EEG, PLR, SSEP CPC 4-5 6 months 0 6-12h, 18-24h, 48-72h
18 prospective cohort 13 2 prehypothermia era NA SSEP GOS 1-3 10 days 9 within 24h and 72h
19 prospective cohort 45 0 TH and TTM 36°C mixed EEG, MR, PLR,
SSEP
CPC 3-5 6 months 0 72h
20 retrospective chart review
33 1 no TTM and TH NA SSEP GOS 1-3 near 4 months 14 while in ICU and
during rehabilitation stay 21 retrospective chart
review
6 0 TH OHCA CR, MR, NSE,
OC, PLR, SSEP
CPC 4-5 2 months 0 more than 48h after
termination of analgosedation 22 retrospective chart
review
13 0 TH OHCA CR, EEG, MR,
PLR, SSEP
mild or no neurological
sequelae
1 month 0 72h
23 case report 1 1 no TTM OHCA EEG, MR, MRI,
PLR, SSEP
CPC 2 20 days - day 5, 6, and 7
24 retrospective chart review
4 0 TH mixed EEG, MR, MRI,
NSE, SSEP
CPC 3-5 6 months 0 24h after start of
normothermia 5 retrospective chart
review
36 1 TH mixed SSEP CPC 3-5 hospital
discharge
4 48-72h
25 retrospective chart review
7 0 TH mixed AEP, CR, EEG,
MR, MRI, myoclonus, OC,
PLR, SSEP
GOS 1-2 6 months 0 within 72h
8 retrospective chart review
14 0 TH mixed NSE, SSEP CPC 4-5 hospital
discharge
0 variable, mainly within 24h
26 case report 1 0 TH OHCA PLR, CT, EEG,
SSEP
CPC 4 hospital
discharge
- 11h and day 5
27 case report 1 0 TH OHCA EEG, MR, MRI,
PLR, SSEP
CPC 3 10 years - day 5 and 8
28 prospective cohort 61 0 TH and TTM 36°C NA CR, EEG, MR,
myoclonus, NSE, PLR, SSEP
CPC 3-5 3 months 0 normothermia
29 prospective cohort 14 0 TH* mixed CR, MR,
myoclonus, NSE, PLR, SSEP
GOS 1-2 3 months 0 after 72 h
30 retrospective chart review
24 0 TH mixed MR, myoclonus,
SSEP
CPC 3-5 hospital
discharge
0 72-96h
31 randomized
controlled trial
3 0 TH* OHCA AEP, SSEP CPC 3-5 6 months 0 24-28h
32 case report 1 1 TH OHCA EEG, myoclonus,
SSEP
descriptive 6 months - day 20
6 prospective cohort 21 1 prehypothermia era mixed CR, EEG, MR,
PLR, SSEP
GOS 1-2 3 months 6 24-72h
33 retrospective chart review
17 0 TH mixed EEG, MR, PLR,
SSEP
CPC 3-5 6 months 0 within 72h
34 prospective cohort 4 0 TH* NA CR, EEG, MR,
NSE, PLR, S- 100B, SSEP
GOS 1-2 1 month 0 24h, 48h, and 72h
*This study included subjects from the prehypothermia era and also subjects managed with hypothermia. Only subjects managed with hypothermia were included in this analysis.
** One subject had indeterminate SSEPs and good outcome
NA: not available; TTM: Targeted Temperature Management; TH: Therapeutic Hypothermia (32-34°C); VF: ventricular fibrillation; VT: ventricular tachycardia; ROSC: return of spontaneous circulation;
OHCA: out-of-hospital cardiac arrest; IHCA: in-hospital cardiac arrest; CR: corneal reflex; MR: motor response; PLR: pupillary light reflex; NSE: normal serum enolase; SSEP: somatosensory evoked potentials; ICU: intensive care unit