Author and
Year Study Design Surgical
Indication Intervention and Control
Treatment Arm and Control Arms (n)
SSI Incidence (n (%))
Rosengren et al. 2018*
Double- blinded randomized controlled trial
MMS for biopsy proven
aggressive tumors on the ear and nose
T: 2 g cephalexin administered 40–
60 min prior to surgery
C: Placebo T: 77
C: 77 T: 5 (6.49)
C: 16 (20.8)
Cherian et al. 2013*
Randomized controlled trial (unblinded)
MMS in nasal swab positive and negative patients
T: 2g cephalexin 30- 60 minutes pre- operative and 1g cephalexin 6 hours after surgery in nasal swab positive (S.
aureus) patients C: Placebo: no prophylaxis given in
swab negative patients T: 89
C: 514 T: 8 (8.99)
C: 31 (6.03)
Mailler- Savage et al.
2008
Prospective randomized trial
MMS for auricular neoplasm with wound left to heal by secondary intention
T: levofloxacin 500mg daily and local wound care
C: local wound care
alone T: 40
C: 42 T: 1 (2.50)
C: 1 (2.38)
Huether et al. 2002
Blinded randomized controlled trial
MMS in patients whom reconstruction was to be performed
T: intra-incisional local anesthetic with clindamycin solution 15 minutes prior to reconstruction C: Placebo (anesthetic without clindamycin
solution) T: 598
C: 574 T: 6 (1.00)
C: 23 (4.01)
Griego et al.
1998
Blinded randomized controlled
trial MMS after
reconstruction
T: local anesthesia with nafcillin sodium in buffered lidocaine C: Placebo (anesthetic without nafcillin
sodium solution) T: 461
C: 447 T: 0 (0)
C: 10 (2.23)
