Supplement 1. Multivariate model (M2) showing 5-year melanoma-specific survival analysis
for overall sample, SEER, 2003-2012.
Independent variable Melanoma-specific mortality
HR (95% CI) P value
Surgery type
MMS 1 [Reference]
NME 0.85 (0.61-1.18) .32
WME 0.93 (0.66-1.31) .67
Ethnicity
Non-Hispanic 1 [Reference]
Hispanic 1.4 (0.94-2.08) .10
Year of Diagnosis
2004 1 [Reference]
2005 0.93 (0.71-1.21) .57
2006 0.81 (0.62-1.05) .12
2007 0.66 (0.5-0.87) .003
2008 0.65 (0.49-0.86) .003
2009 0.68 (0.5-0.92) .01
2010 0.42 (0.29-0.62) <.001
2011 0.44 (0.27-0.71) .001
2012 0.69 (0.29-1.62) .39
Race
White 1 [Reference]
Black NA
Native American NA
Asian 1.25 (0.46-3.41) .66
Unknown 0.58 (0.27-1.25) .16
Gender
Male 1 [Reference]
Female 0.59 (0.48-0.72) <.001
Age at diagnosis (continuous) 1.03 (1.03-1.04) <.001
Marital Status
Single 1 [Reference]
Married 0.71 (0.56-0.92) .009
Separated 0.89 (0.32-2.45) .82
Divorced 0.65 (0.41-1.02) .06
Widowed 1.00 (0.72-1.39) .98
Domestic partner NA
Unknown 0.56 (0.40-0.80) .001
SEER Regiona
San Francisco-Oakland SMSA 1 [Reference]
Connecticut 1.14 (0.69-1.9) .61
Metropolitan Detroit 0.96 (0.52-1.77) .90
Hawaii 0.53 (0.21-1.37) .19
Iowa 0.88 (0.46-1.68) .69
New Mexico 1.02 (0.51-2.05) .95
Seattle (Puget Sound) 0.86 (0.49-1.53) .61
Utah 0.93 (0.49-1.74) .81
Metropolitan Atlanta 0.62 (0.3-1.3) .21
San Jose-Monterey 0.9 (0.49-1.65) .74
Los Angeles 0.74 (0.43-1.25) .26
Rural Georgia 1.42 (0.32-6.38) .64
Greater California (excluding SF, Los Angeles & SJ) 0.93 (0.6-1.45) .76
Kentucky 1.11 (0.63-1.96) .72
Louisianab 1.31 (0.72-2.35) .37
Abbreviations: MIS, melanoma-in-situ; IM, invasive melanoma; MMS, Mohs micrographic surgery; NME, narrow margin excision; WME, wide margin excision; HR, hazard ratio; CI, confidence interval; NA, not available; SEER;
Surveillance, Epidemiology, and End Results.
aExcludes 3 cases from Alaska
bData from 2005 excludes months: August – December due to Hurricane Katrina.
cIncludes localized, regional, and distant stage lesions.