Supplementary Table 2: Comparison of clinical and laboratory parameters collected at baseline between different patient groups defined by bactDNA levels. Values were depicted as mean ± SD (range).
Variable bactDNA-negative
(n=102)
bactDNA-positive (n=71)
OR (95% CI) Level of significance
bactDNA-negative or bactDNA-positive <520 copies/mL (n=133)
BactDNA-positive >520 copies/mL (n=40)
OR (95% CI) Level of significance
Clinical factors
Sex male/female (%) 79/23 (77.5/22.5) 48/23 (67.6/32.4) 1.65 (0.83, 3.25)
0.151 101/32 (75.9/24.1) 26/14 (65/35) 1.7 (0.79,
3.6)
0.172
Age (years) 56.7 ± 11.2 (25-80) 57.5 ± 11.4 (27- 87)
1.01 (0.98, 1.03)
0.725 56.7 ± 11.7 (25-87) 58.2 ± 9.9 (33-76) 1.01 (0.98, 1.05)
0.434
Body mass index (kg/m2) 27.2 ± 5.2 (17.4-42.5) 27.2 ± 4.5 (18.4- 38.1)
1 (0.92, 1.08) 0.98 27.4 ± 5 (17.43-42.52) 26.6 ± 4.5 (18.4-34) 0.97 (0.88, 1.06)
0.475
Liver function parameters
MELD score 17.2 ± 6 (8-35) 18.3 ± 7.1 (7-38) 1.025 (0.977- 1.075)
0.31 16.8 ± 5.9 (8-35) 20.4 ± 7.7 (7-38) 1.084 (1.026, 1.146)
0.004
INR 1.5 ± 0.3 (1.0-2.8) 1.6 ± 0.4 (1.0-2.9) 2 (0.8, 5.4) 0.159 1.5 ± 0.3 (1-2.8) 1.6 ± 0.5 (1-2.9) 3.62 (1.22, 10.76)
0.021
Bilirubin (μmol/L) 63.8 ± 93 (2.9-609.1) 77.9 ± 100 (9.1- 522.9)
1 (1, 1.01) 0.398 59.7 ± 85.3 (2.9-609.1) 100.3 ± 120.2 (9.1-522.9) 1.004 (1, 1.01)
0.047
AST (ìkat/L) 1.2 ± 1.1 (0.4-6.1) 1.3 ± 1.6 (0.1-8.9) 1.04 (0.8, 1.36) 0.757 1.2 ± 1 (0.35-6.05) 1.5 ± 2 (0.08-8.85) 1.17 (0.89, 1.54)
0.826
GGT (ìkat/L) 3.1 ± 3.4 (0.17-22.39) 2.3 ± 2 (0.37-8.3) 0.9 (0.78, 1.04) 0.164 2.8 ± 3.1 (0.17-22.39) 2.8 ± 2.2 (0.38-8.3) 1 (0.87, 1.15) 0.987 Serum albumin (g/L) 30.3 ± 5.6 (16-47.3) 31 ± 7.2 (16.3-
46.6)
1.02 (0.96, 1.08)
0.585 30.4 ± 5.8 (16-47.3) 31.3 ± 7.7 (16.3-46.6) 1.03 (0.95, 1.1)
0.954
Blood laboratory parameters
Creatinine (μmol/L) 127.8 ± 79.8 (34-509) 116 ± 62.7 (38-42) 1 (0.99, 1) 0.345 125.7 ± 77 (34-509) 114.6 ± 60.6 (38-333) 1 (0.99, 1) 0.452 Glomerular filtration rate
(mL/min/1.73m2)
55.8 ± 27.4 (10.7- 130.7)
62.1 ± 28.8 (15.5- 133.7)
1.01 (0.99, 1.02)
0.243 57.9 ± 27.6 (10.7-130.7) 60.1 ± 30.1 (15.5-133.7) 1 (0.99, 1.02) 0.735
Serum sodium (mmol/L) 134.1 ± 5.1 (117.3- 144.2)
134.3 ± 5.4 (112,5-146.7)
1.01 (0.94, 1.07)
0.863 134.1 ± 5.3 (112.5- 144.2)
134.5 ± 5.3 (122.1-146.7) 1.01 (0.94, 1.09)
0.736
Leukocyte count (exp9/L) 9. ± 7.7 (2.5-49.7) 7.2 ± 4.1 (1.2- 20.5)
0.94 (0.87, 1.01)
0.08 8.8 ± 7.1 (2.5-49.7) 6.5 ± 3.8 (1.2-15.7) 0.9 (0.8, 1) 0.053
C-reactive protein (mg/L) 35.8 ± 34.5 (1.3- 186.2)
36.7 ± 33.6 (1.2- 145.9)
1 (0.99, 1.01) 0.882 34.7 ± 33.6 (1.2-186.2) 41.8 ± 35.6 (2.3-145.9) 1.01 (0.99, 1.02)
0.311
Thrombocyte count (exp9/L)
161.5 ± 133 (29-846) 126.5 ± 73.9 (16- 308)
1 (0.99, 1) 0.077 155.1 ± 123.2 (16-846) 121.3 ± 70.5 (25-292) 1 (0.99, 1) 0.134
Ascites parameters Ascites protein content
(g/L)
14.8 ± 9.1 (3.1-50.9) 13.3 ± 8 (2.7-46.6) 0.98 (0.94, 1.02)
0.318 14.4 ± 8.8 (2.7-50.9) 13.3 ± 8.3 (4.8-46.6) 0.99 (0.94, 1.03)
0.535
Leukocyte count /mm3 ascites
275.4 ± 327.7 (0- 1,900)
677.5 ± 1876.9 (0- 12,300)
1 (1, 1) 0.131 272.5 ± 339.5 (0-2130) 1013.8 ± 2466 (50- 12,300)
1 (1, 1) 0.061
Concomitant drugs
Beta-blocker yes/no (%) 41/51 (44.6/55.4) 22/37 (37.3/62.7) 0.74 (0.38, 1.44)
0.377 55/64 (46.2/53.8) 8/24 (25/75) 0.39 (0.16,
0.93)
0.034
Protone pump inhibitors yes/no (%)
54/37 (59.3/40.7) 35/24 (59.3/40.7) 1 (0.5, 1.95) 0.998 73/45 (61.9/38.1) 16/16 (50/50) 0.6 (0.28, 0.62)
0.228
Lactulose yes/no (%) 53/35 (60.2/39.8) 34/21 (61.8/38.2) 1.07 (0.5, 2,14) 0.850 68/45 (60.2/39.8) 19/11 (63.3/36.7) 1.14 (0.5, 1.63)
0.753
Antibiotics at
paracentesis yes/no (%)
32/62 (34/66) 18/52 (30/70) 0.83 (0.41, 1.67)
0.602 40/82 (32.8/67.2) 10/22 (31.3/68.8) 0.93 (0.4, 2.15)
0.869
Antibiotics within one week prior paracentesis yes/no (%)
25/69 (26.6/73.4) 11/49 (18.3/81.7) 0.62 (0.3, 1.38) 0.24 29/93 (23.8/76.2) 7/25 (21.9/78.1) 0.9 (0.35, 2.29)
0.822
Antibiotics within four weeks after paracentesis yes/no (%)
40/45 (47.1/52.9) 32/20 (61.5/38.5) 1.8 (0.89, 3.36) 0.101 51/57 (47.2/52.8) 21/8 (72.4/27.6) 2.93 (1.2, 7.2)
0.019
