Electronic Supplemental Tables
Supplemental Table 1: Risk estimates (ORs, 95% CI) for severe stroke, disability or death at discharge and 1-month mortality in ischemic stroke patients with treated hypertension, NASIS 2004-2013, N=3915
Severe stroke a (NIHSS ≥11)
Disability or death at discharge (mRS≥2) a
1-month mortality b
Hypertension treatment Without β-blocker With β-blocker
1 (Ref.) 1.09 (0.90-1.32)
1 (Ref.) 0.87 (0.73-1.03)
1 (Ref.) 0.99 (0.74-1.31)
Age, per 1-year 1.03 (1.02-1.04) 1.05 (1.05-1.06) 1.04 (1.02-1.05)
Gender Women Men
1 (Ref.) 0.77 (0.63-0.93)
1 (Ref.) 0.99 (0.83-1.18)
--
Hospitalization ward Other
Neurology w/stroke unit
1 (Ref.) 1.24 (0.92-1.69)
1 (Ref.) 0.83 (0.64-1.07)
--
Stroke severity NIHSS≤5 NIHSS 6-10 NIHSS ≥11
-- -- --
1 (Ref.) 5.88 (4.73-7.31) 30.64 (18.72-50.14)
1 (Ref.) 2.71 (1.72-4.30) 11.87 (7.94-17.75)
SBP, quartiles ≤139 mmHg 140-156 mmHg 157-176 mmHg >176 mmHg
1 (Ref.) 0.88 (0.68-1.13) 0.89 (0.69-1.17) 0.93 (0.72-1.21)
1 (Ref.) 0.84 (0.67-1.07) 1.14 (0.88-1.42) 1.01 (0.79-1.29)
1 (Ref.) 0.67 (0.46-0.99) 0.72 (0.49-1.06) 0.68 (0.47-0.99)
Atrial fibrillation 1.61 (1.31-1.99) 1.22 (0.97-1.54) --
Diabetes Mellitus 1.12 (0.93-1.36) 1.69 (1.42-2.01) --
Prior stroke 1.28 (1.05-1.55) 1.80 (1.49-2.16) --
Prior heart disease 1.31 (1.03-1.59) 1.19 (0.99-1.44) --
Reperfusion therapy 3.98 (2.54-6.25) 0.37 (0.22-0.63) 0.61 (0.30-1.23)
Oxfordshire classification Lacunar
Total Anterior Circulation Partial Anterior Circulation Posterior Circulation Unknown
1 (Ref.) 42.75 (28.18-64.85)
4.71 (3.44-6.46) 1.72 (1.19-2.51) 1.79 (1.04-3.08)
1 (Ref.) 3.80 (1.64-8.81) 1.02 (0.83-1.27) 1.00 (0.80-1.25) 0.71 (0.50-1.02)
-- -- -- -- -- NASIS period
2004 2007 2010 2013
1 (Ref.) 1.01 (0.79-1.30) 0.69 (0.52-0.90) 0.47 (0.35-0.63)
1 (Ref.) 0.95 (0.75-1.22) 1.05 (0.82-1.34) 1.12 (0.87-1.44)
-- -- -- --
Statins use before stroke 0.83 (0.68-1.02) 0.74 (0.62-0.88) --
NIHSS: National Institutes of Health Stroke Scale score. Atrial fibrillation: by history of chronic or paroxysmal atrial fibrillation or diagnosed during hospitalization. Prior heart disease included chronic heart failure, prior myocardial infarction, angina pectoris or valve disease.
a. Models included age, gender, systolic blood pressure (SBP) on admission, reperfusion therapy, ischemic stroke severity (by NIHSS), ischemic stroke clinical subtype (by Oxfordshire classification), hospitalization ward, atrial fibrillation, diabetes mellitus, prior stroke, prior heart disease and use of statins on admission.
b. Information on 1-month mortality was available for 2797 (71%) participants. Model included age, SBP on admission, stroke severity and reperfusion therapy as covariates.
Supplemental Table 2: Risk estimates (ORs, 95% CI) for severe stroke, disability or death at discharge and 1-month mortality in ischemic stroke patients on hypertension monotherapy, NASIS 2004-2013, n=1449
Severe stroke a (NIHSS ≥11)
Disability or death at discharge b (mRS≥2)
1-month mortality c
Hypertension medication Without β-blocker β-blocker
1 (Ref.) 1.28 (0.95-1.71)
1 (Ref.) 0.77 (0.56-1.07)
1 (Ref.) 1.11 (0.67-1.83)
Age, per 1-year 1.04 (1.03-1.05) 1.06 (1.04-1.07) 1.05 (1.02-1.07)
Gender Women Men
-- 1 (Ref.)
1.03 (0.77-1.38)
--
Hospitalization ward Other
Neurology w/stroke unit
-- 1 (Ref.)
0.84 (0.56-1.27)
--
Stroke severity NIHSS≤5 NIHSS 6-10 NIHSS ≥11
-- -- --
1 (Ref.) 6.57 (4.59-9.41) 29.64 (13.74-63.94)
1 (Ref.) 2.06 (1.03-4.13) 7.81 (4.28-14.26) SBP, quartiles
≤139 mmHg 140-156 mmHg 157-176 mmHg >176 mmHg
1 (Ref.) 0.80 (0.55-1.15) 0.75 (0.51-1.10) 0.92 (0.63-1.33)
1 (Ref.) 0.92 (0.63-1.35) 1.06 (0.71-1.58) 0.93 (0.61-1.40)
1 (Ref.) 0.50 (0.26-0.94) 0.60 (0.32-1.13) 0.54 (0.29-1.03)
Atrial fibrillation 2.24 (1.64-3.07) 1.13 (0.74-1.74) --
Diabetes Mellitus -- 1.94 (1.44-2.60) --
Prior stroke -- 1.72 (1.25-2.36) --
Prior heart disease -- 1.33 (0.95-1.85) --
Reperfusion therapy -- 0.57 (0.23-1.39) 0.58 (0.17-2.06)
Oxfordshire classification
Lacunar -- 1 (Ref.) --
Total Anterior Circulation Partial Anterior Circulation Posterior Circulation
Unknown
3.13 (0.95-10.27) 1.23 (0.86-1.75) 1.20 (0.83-1.74) 0.67 (0.38-1.19) NASIS period
2004 2007 2010 2013
-- 1 (Ref.)
1.00 ) 0.67-1.50 (
1.01 ) 0.67-1.53 (
1.17 ) 0.76-1.79 (
--
Statins use before stroke -- (0.53-0.94) 0.71 --
NIHSS: National Institutes of Health Stroke Scale score. Atrial fibrillation: by history of chronic or paroxysmal atrial fibrillation or diagnosed during hospitalization. Prior heart disease included chronic heart failure, prior myocardial infarction, angina pectoris or valve disease.
