Supplementary Table 3: Decline in incidence of tuberculosis (TB) from 2005 to 2009 in human immunodeficiency virus (HIV) -infected and -uninfected African children 3 months to <15 years of age.
2005 2006 2007 2008 2009 IRRa p-valueb %Reductionc
Incidence of TBd [95%CI]
(N of TB cases)
Incidence of TB [95%CI]
(N of TB cases)
Incidence of TB [95%CI]
(N of TB cases)
Incidence of TB [95%CI]
(N of TB cases)
Incidence of TB [95%CI]
(N of TB cases)
Overall TB 274.3[256.3-293.2] 216.5[200.9-233.1] 177.9[163.9-192.8] 178.6[164.7-193.4] 165.8[152.6-179.9] 0.60[0.54-0.67] <0.0001 39.6[32.8-45.6]
(861) (706) (594) (610) (579)
HIV-infected 6556.6[6031.4-7112.8] 4553.9[4136.4-5000.5] 3612.4[3252.7-3999.8] 3291.7[2959.8-3649.7] 2861.5[2561.7-3185.9] 0.44[0.38-0.50] <0.0001 56.4[50.1-61.9]
(540) (418) (356) (348) (323)
HIV-uninfected 74.6[65.2-84.9] 64.1[55.6-73.5] 53.4[45.7-62.0] 67.1[58.6-76.5] 69.0[60.4-78.4] 0.92[0.77-1.11] 0.6236 7.5[-10.9-22.9]
(228) (203) (173) (222) (233)
Confirmed TB 69.8[60.8-79.7] 67.8[59.4-77.3] 44.9[38.0-52.7] 31.9[26.2-38.5] 25.8[20.7-31.7] 0.37[0.29-0.47] <0.0001 63.1[52.8-71.1]
(219) (221) (150) (109) (90)
HIV-infected 1566.3[1309.3-1858.3] 1263.8[1045.4-1513.8] 913.2[735.0-1121.4] 548.6[416.9-708.7] 460.7[344.2-603.7 0.29[0.21-0.41] <0.0001 70.6[59.5-78.7]
(129) (116) (90) (58) (52)
HIV-uninfected 18.7[14.1-24.2] 22.7[17.8-28.6] 13.6[9.9-18.2] 13.3[9.7-17.9] 11.0[7.7-15.1] 0.59[0.39-0.89] 0.0003 41.3[11.1-61.2]
(57) (72) (44) (44) (37)
Probable TB 20.1[15.4-25.7] 13.8[10.1-18.5] 3.6[1.9-6.3] 3.5[1.8-6.1] 6.3[3.6-9.5] 0.31[0.19-0.51] <0.0001 68.6[49.0-80.7]
(63) (45) (12) (12) (22)
HIV-infected 449.3[316.5-618.7] 239.7[150.3-362.7] 71.0[28.6-146.3] 47.3[15.4-110.3] 70.9[30.6-139.6] 0.16[0.07-0.34] <0.0001 84.2[66.1-92.6]
(37) (22) (7) (5) (8)
HIV-uninfected 6.9[4.3-10.5] 4.4[2.4-7.4] 1.2[0.3-3.1] 1.8[0.7-3.9] 3.3[1.6-5.8] 0.47[0.23-0.98] 0.0036 52.6[17.3-77.1]
(21) (14) (4) (6) (11)
Possible TB 184.5[169.8-200.1] 134.9[122.6-148.2] 129.4[117.5-142.2] 143.2[130.8-156.4] 133.7[121.9-146.4] 0.72[0.64-0.82] <0.0001 27.5[18.1-35.8]
(579) (440) (432) (489) (467)
HIV-infected 4541.0[4101.5-5013.1] 3050.4[2708.2-3422.9] 2628.1[2321.3-2963.4] 2695.8[2395.4-3022.6] 2323.9[2059.5-2625.2] 0.51[0.44-0.60] <0.0001 48.7[40.1-56.1]
(374) (280) (259) (285) (263)
HIV-uninfected 49.1[41.5-57.6] 36.9[30.5-44.3] 38.6[32.1-45.8] 52.0[44.5-60.3] 54.8[47.2-63.2] 1.11[0.90-1.38] 0.3192 Nil
(150) (117) (125) (172) (185)
a