Appendix. Details of patients presenting with PCV serotypes Year of
presentation Age Sex Underlying risk factor for infection
Prior pneumococcal infection
Infection Vaccination Investigation for
immunodeficiency Underlying cause Serotype
19F
2014 13y 2m
F Yes, dysplastic cochlea predisposing to CSF leak
Yes, 2 prior presentations with meningitis (Serotype 19F and unknown)
Sepsis, meningitis Yes Yes Anatomical
abnormality causing CSF leak. No immunodeficiency found
2015 2m M No No Meningitis,
subdural collection
No Yes No
2015 1y 4m F No No Sepsis Yes No -
2016 7y M No No Sepsis, pneumonia No Yes No
2016 15y
1m M No No Sepsis, pneumonia Yes No -
Serotype 1
2011 1y 4m M No No Pneumonia,
bacteremia
Yes No -
Serotype 7F
2011 3y 7m M No No Sepsis, empyema Yes No -
2011 5y 3m M No No Pneumonia,
bacteremia
Yes No -
2011 6y 3m F No No Pneumonia,
bacteremia
Yes No -
2013 6y 8m M No No Sepsis, meningitis,
mastoiditis Yes No -
2013 1y 5m M No No Pneumonia,
bacteremia
Yes No -
2013 2m M No No Sepsis, meningitis Yes No -
2014 2y 3m M Neuroblastoma No Septic shock, Yes No -
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, autologous stem cell transplant
pneumonia
2014 1m M No No Sepsis, meningitis - No -
Serotype 3
2011 1y 3m M No No Pneumonia,
bacteremia Yes No -
2013 2y 5m M No No Sepsis, pneumonia Yes No -
2014 1y 2m M No No Empyema,
necrotizing pneumonia
Yes No -
2016 2y3m M No No Empyema Yes No -
2016 2y
10m
F No No Empyema Yes No -
2016 3y F No No Empyema Yes No -
2016 3y 9m M No No Empyema Yes Yes No
2016 4y 4m F No No Empyema Yes No -
2017 2y 1m M No No Empyema Yes No -
2017 5y
11m M No No Empyema Yes Incomplete No
Serotype 19A
2011 1y 7m M No No Sepsis, pneumonia Yes No -
2011 8m F No No Septic arthritis Yes No -
2011 10m M No No Sepsis, meningitis
with SDC Yes No -
2011 1y 1m M No No Sepsis, meningitis Yes No -
2011 1m M No No Sepsis, meningitis No No -
2011 3y 2m M No No Empyema Yes No -
2011 3m F No No Meningitis No No -
2011 10m M No No Mastoiditis Yes No -
2011 4y 1m F No No Pneumonia,
bacteremia
Yes No -
2012 2y 4m F No No Sepsis, empyema No No -
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2012 4y 4m M No No Empyema Yes No -
2013 7y 2m M Acute
lymphoblastic leukaemia, chemotherapy
No Sepsis Yes No -
2014 3m M No No Sepsis, meningitis
with subdural collection, osteomyelitis
Yes No -
2014 1y
10m
M No No Sepsis, empyema Yes No -
2014 1y F No No Sepsis, empyema Yes No -
Serotype 23F
2016 4y
10m F No No Empyema Yes No -
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